A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

(2019) Mark E. Gurney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway

(2018) Qun Li et al.   BIOMEDICINE & PHARMACOTHERAPY

NMDA receptors in the dorsal hippocampal area are involved in tramadol state-dependent memory of passive avoidance learning in mice

(2018) Majid Jafari-Sabet et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Direct pharmacological Akt activation rescues Alzheimer's disease like memory impairments and aberrant synaptic plasticity

(2018) Jee Hyun Yi et al.   NEUROPHARMACOLOGY

IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts

(2018) Xiaomeng Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

(2018) Chong Zhang et al.   NEUROPSYCHOPHARMACOLOGY

An IonStar Experimental Strategy for MS1 Ion Current-Based Quantification Using Ultrahigh-Field Orbitrap: Reproducible, In-Depth, and Accurate Protein Measurement in Large Cohorts

(2017) Xiaomeng Shen et al.   JOURNAL OF PROTEOME RESEARCH

Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

(2017) Chong Zhang et al.   Scientific Reports

Surfactant-Aided Precipitation/on-Pellet-Digestion (SOD) Procedure Provides Robust and Rapid Sample Preparation for Reproducible, Accurate and Sensitive LC/MS Quantification of Therapeutic Protein in Plasma and Tissues

(2015) Bo An et al.   ANALYTICAL CHEMISTRY

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Brain sites involved in fear memory reconsolidation and extinction of rodents

(2015) Elisabetta Baldi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Caspase Functions in Cell Death and Disease: Figure 1.

(2015) David R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Highly Multiplexed and Reproducible Ion-Current-Based Strategy for Large-Scale Quantitative Proteomics and the Application to Protein Expression Dynamics Induced by Methylprednisolone in 60 Rats

(2014) Eslam Nouri-Nigjeh et al.   ANALYTICAL CHEMISTRY

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Radiation-induced signaling pathways that promote cancer cell survival (Review)

(2014) ASHLEY L. HEIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

(2013) D Westphal et al.   CELL DEATH AND DIFFERENTIATION

WISP1 Neuroprotection Requires FoxO3a Post-Translational Modulation with Autoregulatory Control of SIRT1

(2013) Shaohui Wang et al.   CURRENT NEUROVASCULAR RESEARCH

Ginsenosides Rg5 and Rh3 protect scopolamine-induced memory deficits in mice

(2013) Eun-Jin Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects

(2012) Zhen-Zhen Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

(2012) Emily M. Johansson et al.   NEUROSCIENCE LETTERS

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

(2011) Kelley Bromley-Brits et al.   Jove-Journal of Visualized Experiments

Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

(2010) H. W. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition

(2009) Véronique Calleja et al.   PLOS BIOLOGY

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY