An intact membrane is essential for small extracellular vesicle‐induced modulation of α‐synuclein fibrillization

The role of lipids in α-synuclein misfolding and neurotoxicity

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Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

(2019) Cathryn L. Ugalde et al.   Disease Models & Mechanisms

Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae

(2018) Ruchi Gupta et al.   PROTEIN EXPRESSION AND PURIFICATION

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Dimerization of Bacterial Diaminopimelate Decarboxylase Is Essential for Catalysis

(2016) Martin G. Peverelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers

(2016) Cathryn L. Ugalde et al.   JOURNAL OF NEUROCHEMISTRY

Defining the purity of exosomes required for diagnostic profiling of small RNA suitable for biomarker discovery

(2016) Camelia Quek et al.   RNA Biology

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

(2015) Paula Garcia-Esparcia et al.   Acta Neuropathologica Communications

Detection of disease-associated α-synuclein in the cerebrospinal fluid: a feasibility study

(2014) Ursula Unterberger et al.   CLINICAL NEUROPATHOLOGY

Acceleration of α-Synuclein Aggregation by Exosomes

(2014) Marie Grey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)

(2014) Maria Eugenia Herva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

(2012) Bradley M. Coleman et al.   FASEB JOURNAL

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Crystal, Solution and In silico Structural Studies of Dihydrodipicolinate Synthase from the Common Grapevine

(2012) Sarah C. Atkinson et al.   PLoS One

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

The Influence of Vesicle Size and Composition on α-Synuclein Structure and Stability

(2009) Lars Kjaer et al.   BIOPHYSICAL JOURNAL

Structure and Evolution of a Novel Dimeric Enzyme from a Clinically Important Bacterial Pathogen

(2008) Benjamin R. Burgess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

(2008) Laura J. Vella et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY