Article
Multidisciplinary Sciences
Taek Yoon Cheong, Sang Duk Hong, Keun-Woo Jung, Yoon Kyoung So
Summary: The study aimed to evaluate the association between systemic inflammatory markers and clinicopathological factors in thyroid cancers. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were significantly higher in cases with lateral lymph node metastasis (LNM). NLR was found to be a significant predictor of thyroid cancers in cases with nodules greater than 2 cm.
Review
Oncology
Alexandra Gomes dos Santos, Rodolfo Figueiredo de Carvalho, Artur Nobrega Lima Rodrigues de Morais, Tamires Martins Silva, Victor Matheus Ribeiro Baylao, Mayara Azevedo, Adilson J. M. de Oliveira
Summary: NLR is a low-cost method associated with tumor grading and overall survival in patients with gliomas.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maurizio A. Leone, Jessica Mandrioli, Sergio Russo, Aliona Cucovici, Giulia Gianferrari, Vitalie Lisnic, Dafin Fior Muresanu, Francesco Giuliani, Massimiliano Copetti, Andrea Fontana
Summary: This study suggests that the neutrophil-to-lymphocyte ratio (NLR) could be a potential marker for disease progression and survival in ALS, possibly associated with low-grade inflammation. Further prospective studies are needed to validate these findings.
Article
Dentistry, Oral Surgery & Medicine
Supriya Mishra, Lynn Johnson, M. P. Gazala, Sheetal Dahiya, Waheda Rahman, V. S. Sreeraj
Summary: The study found that SII is associated with generalized stage III grade C periodontitis in young adults and can predict its occurrence. This multicentered, double-blind, hospital-based case-control clinical study showed that SII has fair predictive validity in detecting the disease, but is not superior to NLR.
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Eden Verter, Yael Berger, Gali Perl, Idit Peretz, Ana Tovar, Sara Morgenstern, Baruch Brenner, Daniel Benchimol, Hanoch Kashtan, Eran Sadot
Summary: This study found that a high preoperative NLR was independently associated with poorer survival outcomes and extrahepatic recurrence pattern in patients with colorectal liver metastasis. These results suggest that NLR may serve as a surrogate marker for aggressive systemic disease after resection.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Immunology
Yiran Chen, Jingya Cai, Mengmeng Zhang, Xin Yan
Summary: This study found that elevated neutrophil-lymphocyte ratio is associated with shorter overall survival in IPF patients and can serve as a reliable prognostic biomarker for IPF.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Claudia Marchetti, Marco D'Indinosante, Carolina Bottoni, Chiara Di Ilio, Stefano Di Berardino, Barbara Costantini, Angelo Minucci, Laura Vertechy, Giovanni Scambia, Anna Fagotti
Summary: The study found that NLR is associated with disease distribution in ovarian cancer patients, with those having NLR<4 more likely to undergo primary debulking surgery and have lower surgical complexity scores. Patients with NLR<4 had a longer median Progression-Free Survival (mPFS), and both BRCA-mutated and BRCA-wild type patients with lower NLR had significantly prolonged mPFS compared to those with higher NLR. BRCA mutational status, complete cytoreduction, and NLR<4 were identified as independent factors of prolonged PFS, while BRCA mutational status, complete cytoreductive surgery, NLR<4, and age were predictors of longer Overall Survival (OS).
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pawel Jarmuzek, Piotr Defort, Marcin Kot, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Agnieszka Zembron-Lacny
Summary: Cytokines play a critical role in tumor cell development and multiplication, but their involvement in glioblastoma (GBM) is still not well understood. This study evaluated the inflammatory profile and identified potential molecular signatures specific to GBM. The results showed elevated neutrophils and neutrophil-to-lymphocyte ratio (NLR) in GBM patients, with an inverse correlation between neutrophil count and survival time. Pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8 were significantly higher in GBM, while TNF alpha and HMGB1 were lower. IL-6 and IL-8 had the highest diagnostic potential for clinical prognosis, with a three-fold higher probability of GBM development above certain threshold values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rina Di Bonaventura, Maurizio Martini, Tonia Cenci, Valerio Maria Caccavella, Valeria Barresi, Marco Gessi, Alessio Albanese, Liverana Lauretti, Roberto Pallini, Quintino Giorgio D'Alessandris, Alessandro Olivi
Summary: Meningiomas, mostly benign tumors, can sometimes display aggressive behavior and recurrence despite complete resection. This study investigated the role of SOX2 in predicting the aggressiveness of meningioma and found that SOX2 expression at first surgery is strongly related to the clinical behavior, histological grade, and risk of recurrence of meningioma. Additionally, SOX2 expression is associated with overall and recurrence-free survival in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Yang-Yu Huang, Shen-Hua Liang, Yu Hu, Xuan Liu, Guo-Wei Ma
Summary: Systemic nutrition and immune inflammation are crucial in cancer development and metastasis. This study compared and assessed four nutritional and immune indicators as prognostic factors for patients with thymic epithelial tumors. The study suggests that preoperative nutritional risk index, neutrophil-to-lymphocyte ratio, and a combined nutritional risk index-neutrophil-to-lymphocyte ratio model may be important prognostic factors for these patients.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Kaustav P. Shah, Haocan Song, Fei Ye, Douglas B. Johnson
Summary: In patients with BRAF(V600)-mutated melanoma, the number of distinct tumor sites at the initiation of targeted therapy is associated with survival, while serum lactate dehydrogenase values and the absolute lymphocyte count to absolute neutrophil count ratio are strong predictors of prognosis. Using both of these markers can help stratify prognosis for patients with metastatic melanoma receiving targeted therapy.
Article
Oncology
Tomoki Abe, Taro Oshikiri, Hironobu Goto, Takashi Kato, Manabu Horikawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
Summary: The Alb-dNLR score has been shown to be an independent prognostic factor for ESCC patients, and can predict both overall survival and cause-specific survival rates by analyzing albumin and the neutrophil-to-lymphocyte ratio.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Bong Kyung Bae, Hee Chul Park, Gyu Sang Yoo, Moon Seok Choi, Joo Hyun Oh, Jeong Il Yu
Summary: This retrospective study evaluated the significance of systemic inflammatory markers (SIMs) in intrahepatic recurrence (IHR) of early-stage hepatocellular carcinoma (HCC) after curative treatment. The study found that SIMs were significantly associated with the prognosis of early-stage HCC patients who received initial curative treatment. The prognostic significances of SIMs were consistent for IHR-free survival, early and late IHR, and overall survival.
Article
Clinical Neurology
Ryota Tamura, Hiroyuki Miyoshi, Kazunari Yoshida, Hideyuki Okano, Masahiro Toda
Summary: Malignant glioma, a highly aggressive primary brain tumor, has poor prognosis and requires new therapeutic modalities. Suicide gene therapy has gained attention, with recent focus on using tumor-tropic stem cells as cellular delivery vehicles. This approach shows potential for effective treatment of malignant gliomas.
NEUROSURGICAL REVIEW
(2021)
Article
Medicine, General & Internal
Yuki Kuranari, Ryota Tamura, Noboru Tsuda, Kenzo Kosugi, Yukina Morimoto, Kazunari Yoshida, Masahiro Toda
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Ryota Tamura, Yukina Morimoto, Kenzo Kosugi, Mizuto Sato, Yumiko Oishi, Ryo Ueda, Ryogo Kikuchi, Hideaki Nagashima, Shinobu Noji, Yutaka Kawakami, Hikaru Sasaki, Kazunari Yoshida, Masahiro Toda
Article
Oncology
Ryota Tamura, Toshihide Tanaka, Yukina Morimoto, Yuki Kuranari, Yohei Yamamoto, Jun Takei, Yuichi Murayama, Kazunari Yoshida, Hikaru Sasaki
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Pathology
Ryota Tamura, Mizuto Sato, Yukina Morimoto, Kentaro Ohara, Kenzo Kosugi, Yumiko Oishi, Yuki Kuranari, Makoto Murase, Kazunari Yoshida, Masahiro Toda
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2020)
Article
Pathology
Makoto Murase, Ryota Tamura, Yuki Kuranari, Mizuto Sato, Kentaro Ohara, Yukina Morimoto, Kazunari Yoshida, Masahiro Toda
Summary: The depth and patterns of dural invasion in meningiomas were quantitatively evaluated, and it was found that the invasion patterns were associated with meningioma recurrence.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Immunology
Ryota Tamura, Yukina Morimoto, Mizuto Sato, Tetsuro Hikichi, Kazunari Yoshida, Masahiro Toda
Article
Clinical Neurology
Mizuto Sato, Ryota Tamura, Yukina Morimoto, Yumiko Oishi, Kazunari Yoshida, Masahiro Toda
Summary: This study found an association between activated fibroblasts and dura matere-like membrane capsules in LVMs. The characteristics of membranous structure in LVMs may differ depending on tumor size.
WORLD NEUROSURGERY
(2021)
Review
Biochemistry & Molecular Biology
Ryota Tamura
Summary: Neurofibromatosis is a neurocutaneous syndrome characterized by tumors in the nervous system, with NF1, NF2, and SWN as its three main types. While NF1 and NF2 have known genetic mutations and targeted therapies, the molecular mechanisms of SWN remain unclear and require further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yumiko Oishi, Ryota Tamura, Kazunari Yoshida, Masahiro Toda
Summary: The dura-like membrane (DLM) is an membranous structure arising from the dura mater adjacent to the internal auditory meatus that envelops some vestibular schwannomas (VSs). Recognition of DLM is important for preserving facial and cochlear nerves during tumor resection. The study found that the presence of DLM was associated with lower tumor resection volume, larger intratumoral vessel diameter, and higher intratumoral microvessel density.
Review
Biochemistry & Molecular Biology
Ryota Tamura, Masahiro Toda
Summary: Vestibular schwannoma is a benign tumor that originates from Schwann cells. Gamma knife radiosurgery is an accepted treatment, while targeted therapy and immunotherapy show potential for refractory cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kento Takahara, Makoto Katayama, Ryota Tamura
Summary: Leptomeningeal carcinomatosis (LMC) is a rare but devastating complication of advanced cancer, more commonly caused by breast cancer, lung cancer, and melanoma. Treatment with intrathecal chemotherapy via Ommaya reservoir and radiation therapy has shown success in prolonging survival in patients with LMC from ovarian cancer.
Article
Biotechnology & Applied Microbiology
Ryota Tamura, Hiroyuki Miyoshi, Kent Imaizumi, Masahiro Yo, Yoshitaka Kase, Tsukika Sato, Mizuto Sato, Yukina Morimoto, Oltea Sampetrean, Jun Kohyama, Munehisa Shinozaki, Atsushi Miyawaki, Kazunari Yoshida, Hideyuki Saya, Hideyuki Okano, Masahiro Toda
Summary: This study demonstrates the potential benefit of gene-edited induced pluripotent stem cells (iPSCs) for the treatment of invasive glioma stem cells (GSCs). Neural stem cells (NSCs) derived from CRISPR/Cas9-edited iPSCs expressing a suicide gene showed enhanced tumor-trophic migratory capacity and significant in vivo antitumor effects. The study also identified key signaling pathways and gene expressions associated with the efficacy of therapeutic iPSC-NSCs.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ryota Tamura
Summary: Drug repositioning is the process of identifying new therapeutic potentials for approved drugs and discovering new therapies for untreated diseases. It can save time and cost compared to de novo drug discovery. This article reviews the utility of drug repositioning for refractory benign tumors of the central nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ryosuke Tomio, Takashi Horiguchi, Hamid Borghei-Razavi, Ryota Tamura, Kazunari Yoshida, Takeshi Kawase
Summary: The anterior transpetrosal approach (ATPA) has been used for surgery since 1985, and this study analyzed 274 cases performed from 1984 to 2017. Petroclival meningioma was the most common diagnosis. Modifications to the ATPA, such as zygomatic osteotomy, were used to decrease complications, but brain injury and CSF leak remained unresolved problems. Facial nerve damage decreased after 2010, but CSF leak incidence did not improve.
JOURNAL OF NEUROSURGERY
(2022)