Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death

Serum SNTF, a Surrogate Marker of Axonal Injury, Is Prognostic for Lasting Brain Dysfunction in Mild TBI Treated in the Emergency Department

(2020) Robert Siman et al.   Frontiers in Neurology

Calpain-2 as a therapeutic target in repeated concussion–induced neuropathy and behavioral impairment

(2020) Yubin Wang et al.   Science Advances

Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice

(2019) Soomaayeh Heysieattalab et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice

(2018) Yubin Wang et al.   JOURNAL OF NEUROTRAUMA

Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects

(2018) Faraz Ahmad et al.   Scientific Reports

CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia

(2018) Aakash Shetty et al.   European Journal of Medical Genetics

Calpain-14 and its association with eosinophilic esophagitis

(2017) Vladislav A. Litosh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation

(2017) Yubin Wang et al.   Scientific Reports

Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction

(2017) Guoqi Zhu et al.   Scientific Reports

Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia

(2016) Ziv Gan-Or et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury

(2016) Yubin Wang et al.   NEUROBIOLOGY OF DISEASE

Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration

(2016) Michel Baudry et al.   TRENDS IN NEUROSCIENCES

Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia–reperfusion injury

(2016) Q Zhao et al.   Cell Death & Disease

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans

(2016) Yubin Wang et al.   Cell Reports

Cerebellar learning mechanisms

(2015) John H. Freeman   BRAIN RESEARCH

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

Different Patterns of Electrical Activity Lead to Long-term Potentiation by Activating Different Intracellular Pathways

(2015) G. Zhu et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Rapid Local RhoA Synthesis Is Required for Hippocampal Synaptic Plasticity

(2015) V. Briz et al.   JOURNAL OF NEUROSCIENCE

Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Postconcussion Symptoms

(2015) Robert Siman et al.   JOURNAL OF NEUROTRAUMA

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

The role of calpains in traumatic brain injury

(2014) Shuang Liu et al.   BRAIN INJURY

Organization, control and function of extrasynaptic NMDA receptors

(2014) T. Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A molecular brake controls the magnitude of long-term potentiation

(2014) Yubin Wang et al.   Nature Communications

Characterization of the definitive classical calpain family of vertebrates using phylogenetic, evolutionary and expression analyses

(2014) D. J. Macqueen et al.   Open Biology

Calpain-2-Mediated PTEN Degradation Contributes to BDNF-Induced Stimulation of Dendritic Protein Synthesis

(2013) V. Briz et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles for  -Calpain and m-Calpain in Synaptic NMDAR-Mediated Neuroprotection and Extrasynaptic NMDAR-Mediated Neurodegeneration

(2013) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury

(2013) M. Amini et al.   JOURNAL OF NEUROSCIENCE

Control of Synaptic Plasticity and Memory via Suppression of Poly(A)-Binding Protein

(2013) Arkady Khoutorsky et al.   NEURON

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

BDNF mechanisms in late LTP formation: A synthesis and breakdown

(2013) Debabrata Panja et al.   NEUROPHARMACOLOGY

Missense Mutation in CAPN1 Is Associated with Spinocerebellar Ataxia in the Parson Russell Terrier Dog Breed

(2013) Oliver P. Forman et al.   PLoS One

Evidence That the Blood Biomarker SNTF Predicts Brain Imaging Changes and Persistent Cognitive Dysfunction in Mild TBI Patients

(2013) Robert Siman et al.   Frontiers in Neurology

Dismantling the autophagic arsenal when it is time to die

(2012) Marco Corazzari et al.   Autophagy

Regulation and physiological roles of the calpain system in muscular disorders

(2012) H. Sorimachi et al.   CARDIOVASCULAR RESEARCH

Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells

(2012) Toshihiro Nomura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

(2012) C. M. Gladding et al.   HUMAN MOLECULAR GENETICS

Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model

(2012) Mona Bains et al.   JOURNAL OF NEUROCHEMISTRY

Distributed synergistic plasticity and cerebellar learning

(2012) Zhenyu Gao et al.   NATURE REVIEWS NEUROSCIENCE

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

(2012) Takenari Yamashita et al.   Nature Communications

Calpain-5 Mutations Cause Autoimmune Uveitis, Retinal Neovascularization, and Photoreceptor Degeneration

(2012) Vinit B. Mahajan et al.   PLoS Genetics

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

Reevaluating the Role of LTD in Cerebellar Motor Learning

(2011) Martijn Schonewille et al.   NEURON

Calpain-mediated regulation of stargazin in adult rat brain

(2011) L. Yu et al.   NEUROSCIENCE

Comparison of Dysferlin Expression in Human Skeletal Muscle with That in Monocytes for the Diagnosis of Dysferlin Myopathy

(2011) Eduard Gallardo et al.   PLoS One

Brain-Derived Neurotrophic Factor and Epidermal Growth Factor Activate Neuronal m-Calpain via Mitogen-Activated Protein Kinase-Dependent Phosphorylation

(2010) S. Zadran et al.   JOURNAL OF NEUROSCIENCE

αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients

(2010) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

A Pharmacological Analysis of the Neuroprotective Efficacy of the Brain- and Cell-Permeable Calpain Inhibitor MDL-28170 in the Mouse Controlled Cortical Impact Traumatic Brain Injury Model

(2010) Stephanie N. Thompson et al.   JOURNAL OF NEUROTRAUMA

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

The biochemistry of memory: The 26year journey of a ‘new and specific hypothesis’

(2010) Michel Baudry et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Different Rho GTPase–dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

(2009) Christopher S. Rex et al.   JOURNAL OF CELL BIOLOGY

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

αII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury

(2009) Gretchen M. Brophy et al.   JOURNAL OF NEUROTRAUMA

Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity

(2008) Matthew B. Bevers et al.   JOURNAL OF NEUROCHEMISTRY

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

(2008) P. S. Vosler et al.   MOLECULAR NEUROBIOLOGY

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Calpain in the CNS: From Synaptic Function to Neurotoxicity

(2008) J. Liu et al.   Science Signaling