The p53 Pathway and Metabolism: The Tree That Hides the Forest

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

Mdm2 enhances ligase activity of parkin and facilitates mitophagy

(2020) Seunghyi Kook et al.   Scientific Reports

Germline mutation of MDM4, a major p53 regulator, in a familial syndrome of defective telomere maintenance

(2020) Eléonore Toufektchan et al.   Science Advances

Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma

(2020) Madi Y. Cissé et al.   Science Translational Medicine

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

(2019) Xazmin H. Lowman et al.   Cell Reports

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network

(2019) Rana Elkholi et al.   MOLECULAR CELL

The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in nutlin-treated cancer cells

(2019) Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease

(2019) Giovanni Blandino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

(2019) Valentina Sica et al.   Cell Reports

Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche

(2019) Tianyuan Hu et al.   Stem Cell Reports

α-Ketoglutarate links p53 to cell fate during tumour suppression

(2019) John P. Morris et al.   NATURE

Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress

(2019) Irem Kaymak et al.   CANCER RESEARCH

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

(2019) Matthieu Lacroix et al.   Molecular Metabolism

Mdm2 is a target and mediator of IRP2 in cell growth control

(2019) Jin Zhang et al.   FASEB JOURNAL

Control of metabolism by p53 – Cancer and beyond

(2018) Christiaan F. Labuschagne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

(2018) Giuseppe Arena et al.   MOLECULAR CELL

Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects

(2018) Ning Kon et al.   Oncotarget

The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis

(2018) Keerthana Gnanapradeepan et al.   Frontiers in Endocrinology

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

(2018) Mylène Tajan et al.   Cell Metabolism

p53 tumor suppressor and iron homeostasis

(2018) Jin Zhang et al.   FEBS Journal

Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a

(2018) Lei Duan et al.   CANCER BIOLOGY & THERAPY

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

(2018) Sung-Hwan Moon et al.   CELL

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

(2018) Baharan Fekry et al.   Nature Communications

Dysfunction of the MDM2/p53 axis is linked to premature aging

(2017) Davor Lessel et al.   JOURNAL OF CLINICAL INVESTIGATION

Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects ofArftumor suppressor-deficient mice

(2017) Jolieke G. van Oosterwijk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New genes and pathomechanisms in mitochondrial disorders unraveled by NGS technologies

(2016) Andrea Legati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial BMI1 maintains bioenergetic homeostasis in cells

(2016) Soumyajit Banerjee Mustafi et al.   FASEB JOURNAL

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53

(2016) Romain Riscal et al.   MOLECULAR CELL

E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity

(2016) Matthieu Lacroix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis

(2016) Perrine Goguet-Rubio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein-protein interactions by the MDM2 ligand nutlin-3

(2016) Luke Way et al.   PROTEOMICS

The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

(2016) Xiaomu Li et al.   Nature Communications

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

(2016) Yingxiao Chen et al.   Oncotarget

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

(2016) Che-Pei Kung et al.   Cell Reports

The BMI1 polycomb protein represses cyclin G2-induced autophagy to support proliferation in chronic myeloid leukemia cells

(2015) L Mourgues et al.   LEUKEMIA

Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation

(2015) Zheng-Cheng Yu et al.   NUCLEIC ACIDS RESEARCH

TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy

(2015) Rong Zheng et al.   Oncotarget

Regulation of iron homeostasis by the p53-ISCU pathway

(2015) Yuki Funauchi et al.   Scientific Reports

E4F1 Is a Master Regulator of CHK1-Mediated Functions

(2015) David Grote et al.   Cell Reports

The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions

(2015) Geneviève Rodier et al.   Cell Reports

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron

(2014) Rina Shimizu et al.   GENE

p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

(2014) Yang Ou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

(2014) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

(2014) Jia Shen et al.   Cell Reports

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

The B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation

(2013) Michael A. Reid et al.   MOLECULAR CELL

Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

(2013) Ping-Yuan Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

(2013) Ivan Raimondi et al.   PLoS One

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation

(2012) P Hallenborg et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia Activates Tumor Suppressor p53 by Inducing ATR-Chk1 Kinase Cascade-mediated Phosphorylation and Consequent 14-3-3γ Inactivation of MDMX Protein

(2012) Jun-Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

E4F1 deficiency results in oxidative stress–mediated cell death of leukemic cells

(2011) Elodie Hatchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteomic Dissection of the von Hippel–Lindau (VHL) Interactome

(2011) Yanlai Lai et al.   JOURNAL OF PROTEOME RESEARCH

Mieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria

(2011) Noriaki Kitamura et al.   PLoS One

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy

(2010) Kathryn G Eby et al.   Molecular Cancer

Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis

(2010) M. Lacroix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 and ARF: unexpected players in autophagy

(2010) Gregor M. Balaburski et al.   TRENDS IN CELL BIOLOGY

Iron-Dependent Regulation of MDM2 Influences p53 Activity and Hepatic Carcinogenesis

(2009) Paola Dongiovanni et al.   AMERICAN JOURNAL OF PATHOLOGY

Ferritin binds and activates p53 under oxidative stress

(2009) Jong-Hyuk Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer

(2009) Diptee A. Kulkarni et al.   CARCINOGENESIS

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

(2009) Francesca Mancini et al.   EMBO JOURNAL

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene

(2009) G. S. Atwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-Dependent and p53-Independent Activation of Autophagy by ARF

(2008) W. M. Abida et al.   CANCER RESEARCH

MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination

(2008) M. Maguire et al.   CANCER RESEARCH

ARF Induces Autophagy by Virtue of Interaction with Bcl-xl

(2008) Julia Pimkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY