Role of Natural Killer Cells in Uveal Melanoma

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

(2020) Carlos R. Figueiredo et al.   JOURNAL OF PATHOLOGY

An Outcome Assessment of a Single Institution’s Longitudinal Experience with Uveal Melanoma Patients with Liver Metastasis

(2020) Rino S. Seedor et al.   Cancers

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma

(2020) Terai et al.   Cancers

ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy

(2020) Jared E Lopes et al.   Journal for ImmunoTherapy of Cancer

Natural Killer Cells: Tumor Surveillance and Signaling

(2020) Lizeth G. Meza Guzman et al.   Cancers

Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis

(2019) Jing Zhou et al.   IMMUNITY

Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4+ T cells

(2019) Zhi-Bin Zhao et al.   Cellular & Molecular Immunology

Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma

(2019) Nyasia M. Jones et al.   BMC CANCER

Expression of immune checkpoint receptors Indoleamine 2,3‐dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma

(2019) Gustav Stålhammar et al.   Cancer Medicine

Pembrolizumab as first-line treatment for metastatic uveal melanoma

(2019) Ernesto Rossi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma

(2019) Haoyu Sun et al.   Cancer Immunology Research

Uterine Natural Killer Cells

(2019) Dorothy K. Sojka et al.   Frontiers in Immunology

Liver-Derived TGF-β Maintains the EomeshiTbetlo Phenotype of Liver Resident Natural Killer Cells

(2019) Cathal Harmon et al.   Frontiers in Immunology

The Roles of Liver-Resident Lymphocytes in Liver Diseases

(2019) Yanan Wang et al.   Frontiers in Immunology

Tebentafusp: T Cell Redirection for the Treatment of Metastatic Uveal Melanoma

(2019) Bertil E. Damato et al.   Cancers

Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma

(2019) Zahra Souri et al.   Cancers

Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets

(2019) Maria Sofia Basile et al.   Frontiers in Oncology

Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)

(2018) Richard D. Carvajal et al.   JOURNAL OF CLINICAL ONCOLOGY

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

(2018) Qing Zhang et al.   NATURE IMMUNOLOGY

Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma

(2018) Anne Marie Lane et al.   JAMA Ophthalmology

IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction

(2018) Nicholas J. W. Easom et al.   Frontiers in Immunology

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy

(2018) Lilla Hornyák et al.   Frontiers in Immunology

The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis

(2018) Constantinos Roufas et al.   Frontiers in Oncology

How to MEK the best of uveal melanoma: A systematic review on the efficacy and safety of MEK inhibitors in metastatic or unresectable uveal melanoma

(2018) Theresa Steeb et al.   EUROPEAN JOURNAL OF CANCER

Association of Uveal Melanoma Metastatic Rate With Stochastic Mutation Rate and Type of Mutation

(2018) Eszter Szalai et al.   JAMA Ophthalmology

Natural Killer Cells: Development, Maturation, and Clinical Utilization

(2018) Alex M. Abel et al.   Frontiers in Immunology

TGF-β secreted by tumor-associated macrophages promotes proliferation and invasion of colorectal cancer via miR-34a-VEGF axis

(2018) Danhua Zhang et al.   CELL CYCLE

The Interferon-Gamma Paradox in Cancer

(2018) M. Raza Zaidi   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Inflammatory cell infiltrates in advanced metastatic uveal melanoma

(2017) Yamini Krishna et al.   HUMAN PATHOLOGY

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy

(2017) William C. Dougall et al.   IMMUNOLOGICAL REVIEWS

PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma

(2017) Asad Javed et al.   Immunotherapy

Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study

(2017) Smita S Chandran et al.   LANCET ONCOLOGY

Targeting TDO in cancer immunotherapy

(2017) Cheng-Peng Yu et al.   MEDICAL ONCOLOGY

Diversity of tissue-resident NK cells

(2017) Hui Peng et al.   SEMINARS IN IMMUNOLOGY

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

(2017) Nicholas A. Manieri et al.   TRENDS IN IMMUNOLOGY

Liver-Resident NK Cells: The Human Factor

(2017) Victoria Male   TRENDS IN IMMUNOLOGY

Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer

(2017) Shuai Zhang et al.   Oncotarget

Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice

(2017) Louise M. Gaynor et al.   Frontiers in Immunology

Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study

(2017) Yong Qin et al.   OncoImmunology

Hobit expression by a subset of human liver-resident CD56bright Natural Killer cells

(2017) Sebastian Lunemann et al.   Scientific Reports

Uveal melanoma: From diagnosis to treatment and the science in between

(2016) Chandrani Chattopadhyay et al.   CANCER

Clinical outcomes in metastatic uveal melanoma treated with PD-1 and PD-L1 antibodies

(2016) Alain P. Algazi et al.   CANCER

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells

(2016) Andrea Kristina Horst et al.   Cellular & Molecular Immunology

Tissue-resident Eomeshi T-betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver

(2016) Cathal Harmon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metastatic ocular melanoma to the liver exhibits infiltrative and nodular growth patterns

(2016) Hans E. Grossniklaus et al.   HUMAN PATHOLOGY

Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

(2016) Kelly Hudspeth et al.   JOURNAL OF AUTOIMMUNITY

EomeshiNK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation

(2016) Antonia O. Cuff et al.   JOURNAL OF IMMUNOLOGY

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

T-bet and Eomesodermin in NK Cell Development, Maturation, and Function

(2016) Federico Simonetta et al.   Frontiers in Immunology

Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating Leukocytes

(2016) T. Huibertus van Essen et al.   PLoS One

CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver

(2016) Kerstin A. Stegmann et al.   Scientific Reports

Identification of an Immunogenic Subset of Metastatic Uveal Melanoma

(2015) L. D. Rothermel et al.   CLINICAL CANCER RESEARCH

Uveal melanoma: Estimating prognosis

(2015) Swathi Kaliki et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a+NK Cells

(2015) Nicole Marquardt et al.   JOURNAL OF IMMUNOLOGY

Phase II DeCOG-Study of Ipilimumab in Pretreated and Treatment-Naïve Patients with Metastatic Uveal Melanoma

(2015) Lisa Zimmer et al.   PLoS One

The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism

(2015) Hua Yang et al.   Oncotarget

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

(2015) Peter Johansson et al.   Oncotarget

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases

(2014) Siân A Pugh et al.   BMC CANCER

TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells

(2014) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Identification and Characterization of a Transmembrane Isoform of CD160 (CD160-TM), a Unique Activating Receptor Selectively Expressed upon Human NK Cell Activation

(2014) J. Giustiniani et al.   JOURNAL OF IMMUNOLOGY

Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?

(2013) Eithne C. Cunningham et al.   Clinical & Developmental Immunology

Treatment of metastatic uveal melanoma with intravenous fotemustine

(2013) Francesco Spagnolo et al.   MELANOMA RESEARCH

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

(2013) Marcel Martin et al.   NATURE GENETICS

Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist

(2013) L. G. Burdelya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

(2013) S. J. Furney et al.   Cancer Discovery

Progression of Ocular Melanoma Metastasis to the Liver

(2013) Hans E. Grossniklaus   JAMA Ophthalmology

NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection

(2013) Mala K. Maini et al.   Frontiers in Immunology

Transhepatic Therapies for Metastatic Uveal Melanoma

(2013) Carin Gonsalves et al.   SEMINARS IN INTERVENTIONAL RADIOLOGY

Expression of 12 cytokines in aqueous humour of uveal melanoma before and after combined Ruthenium-106 brachytherapy and transpupillary thermotherapy

(2012) Christopher Seungkyu Lee et al.   ACTA OPHTHALMOLOGICA

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity

(2012) G. Pietra et al.   CANCER RESEARCH

Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions

(2012) Yan Wu et al.   HEPATOLOGY

Uveal Melanoma: The Inflammatory Microenvironment

(2012) Inge H.G. Bronkhorst et al.   Journal of Innate Immunity

Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial

(2012) Gerald S Falchook et al.   LANCET ONCOLOGY

Influence of CD8+ T regulatory cells on intraocular tumor development

(2012) Kyle C. McKenna et al.   Frontiers in Immunology

Ocular Immune Privilege and Ocular Melanoma: Parallel Universes or Immunological Plagiarism?

(2012) Jerry Y. Niederkorn   Frontiers in Immunology

How melanoma cells inactivate NK cells

(2012) Gabriella Pietra et al.   OncoImmunology

Radioembolization as Salvage Therapy for Hepatic Metastasis of Uveal Melanoma: A Single-Institution Experience

(2011) Carin F. Gonsalves et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients

(2011) A. Curti et al.   BLOOD

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

(2011) Kerry S. Campbell et al.   IMMUNOLOGY

Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy

(2011) DONGDONG WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The biology of micrometastases from uveal melanoma

(2011) N. J. Borthwick et al.   JOURNAL OF CLINICAL PATHOLOGY

Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma

(2010) Dimitrios Mougiakakos et al.   CANCER

Natural Killer Cell Education and Tolerance

(2010) Mark T. Orr et al.   CELL

Prognosis of Uveal Melanoma in 500 Cases Using Genetic Testing of Fine-Needle Aspiration Biopsy Specimens

(2010) Carol L. Shields et al.   OPHTHALMOLOGY

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Metastasis of Uveal Melanoma Millimeter-by-Millimeter in 8033 Consecutive Eyes

(2009) Carol L. Shields   ARCHIVES OF OPHTHALMOLOGY

Long-term survival of uveal melanoma patients after surgery for liver metastases

(2009) S Frenkel et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

The Lytic Potential of Human Liver NK Cells Is Restricted by Their Limited Expression of Inhibitory Killer Ig-Like Receptors

(2009) B. M. Burt et al.   JOURNAL OF IMMUNOLOGY

Natural Cytotoxicity Receptors NKp30, NKp44 and NKp46 Bind to Different Heparan Sulfate/Heparin Sequences

(2009) Marie-Lyn Hecht et al.   JOURNAL OF PROTEOME RESEARCH

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Single-cell tumor dormancy model of uveal melanoma

(2008) Patrick T. Logan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma

(2008) S. Bakalian et al.   CLINICAL CANCER RESEARCH

Immunoembolization of Malignant Liver Tumors, Including Uveal Melanoma, Using Granulocyte-Macrophage Colony-Stimulating Factor

(2008) Takami Sato et al.   JOURNAL OF CLINICAL ONCOLOGY

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE