Deep learning-based clustering robustly identified two classes of sepsis with both prognostic and predictive values

Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness

(2020) Zsolt Zador et al.   CRITICAL CARE MEDICINE

A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections

(2020) Michael B. Mayhew et al.   Nature Communications

Bioinformatics Analysis for Multiple Gene Expression Profiles in Sepsis

(2020) Jianhua Zhai et al.   MEDICAL SCIENCE MONITOR

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials

(2020) Pratik Sinha et al.   Lancet Respiratory Medicine

Deep learning-based cancer survival prognosis from RNA-seq data: approaches and evaluations

(2020) Zhi Huang et al.   BMC Medical Genomics

Whole blood transcriptomic investigation identifies long non-coding RNAs as regulators in sepsis

(2020) Lixin Cheng et al.   Journal of Translational Medicine

Uncovering the key dimensions of high-throughput biomolecular data using deep learning

(2020) Shixiong Zhang et al.   NUCLEIC ACIDS RESEARCH

C14orf159 suppresses gastric cancer cells’ invasion and proliferation by inactivating ERK signaling

(2019) Yan-Mei Zhu et al.   Cancer Management and Research

Identifying Novel Sepsis Subphenotypes Using Temperature Trajectories

(2019) Sivasubramanium V Bhavani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

(2019) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Distinguishing prognostic and predictive biomarkers: an information theoretic approach

(2018) Konstantinos Sechidis et al.   BIOINFORMATICS

The immunosuppressive face of sepsis early on intensive care unit—A large-scale microarray meta-analysis

(2018) Dominik Schaack et al.   PLoS One

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial

(2018) David B Antcliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care

(2018) Matthieu Komorowski et al.   NATURE MEDICINE

Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis

(2017) Yu Kawazoe et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension

(2017) Ben Andrews et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

(2017) Christopher W. Seymour et al.   NEW ENGLAND JOURNAL OF MEDICINE

D-Glutamate is metabolized in the heart mitochondria

(2017) Makoto Ariyoshi et al.   Scientific Reports

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

A comprehensive time-course–based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set

(2015) Timothy E. Sweeney et al.   Science Translational Medicine

Sepsis: From Pathophysiology to Individualized Patient Care

(2015) Ildikó László et al.   Journal of Immunology Research

NbClust: AnRPackage for Determining the Relevant Number of Clusters in a Data Set

(2015) Malika Charrad et al.   Journal of Statistical Software

Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

(2014) Marcello Clerici et al.   Nature Communications

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

(2010) Agnes E. Coutinho et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Stomatin-like Protein-1 Interacts with Stomatin and Is Targeted to Late Endosomes

(2009) Mario Mairhofer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY