Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies

Structure of the AAVhu.37 capsid by cryoelectron microscopy

(2020) Jason T. Kaelber et al.   Acta Crystallographica Section F-Structural Biology Communications

Parvovirus Capsid-Antibody Complex Structures Reveal Conservation of Antigenic Epitopes Across the Family

(2020) Shanan N. Emmanuel et al.   VIRAL IMMUNOLOGY

Co-evolution of AAV capsid antigenicity and tropism through a structure-guided approach

(2020) L. Patrick Havlik et al.   JOURNAL OF VIROLOGY

Estimation of impact of RPE65-mediated inherited retinal disease on quality of life and the potential benefits of gene therapy

(2019) Andrew Lloyd et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue

(2019) Caitlin M. Guenther et al.   MOLECULAR THERAPY

Twenty-Five Years of Structural Parvovirology

(2019) Mietzsch et al.   Viruses-Basel

Developing an Anion Exchange Chromatography (AEX) Assay for Determining Empty and Full Capsid Contents in AAV6.2

(2019) Chunlei Wang et al.   Molecular Therapy-Methods & Clinical Development

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

(2019) Ran Zhang et al.   Nature Communications

Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2

(2019) Antonette Bennett et al.   JOURNAL OF STRUCTURAL BIOLOGY

Atomic structure of a rationally engineered gene delivery vector, AAV2.5

(2018) Matthew Burg et al.   JOURNAL OF STRUCTURAL BIOLOGY

AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition

(2018) Antonette D. Bennett et al.   VIROLOGY

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant

(2018) Yong Zi Tan et al.   Nature Communications

High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors

(2018) Ariana Jose et al.   JOURNAL OF VIROLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies

(2016) Yu-Shan Tseng et al.   JOURNAL OF VIROLOGICAL METHODS

Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids

(2016) Fikret Aydemir et al.   JOURNAL OF VIROLOGY

Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site

(2016) Lin-Ya Huang et al.   JOURNAL OF VIROLOGY

Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging

(2016) Lauren M. Drouin et al.   JOURNAL OF VIROLOGY

An essential receptor for adeno-associated virus infection

(2016) S. Pillay et al.   NATURE

Scalable Downstream Strategies for Purification of Recombinant Adeno- Associated Virus Vectors in Light of the Properties

(2015) Weihong Qu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Alipogene Tiparvovec: A Review of Its Use in Adults with Familial Lipoprotein Lipase Deficiency

(2015) Lesley J. Scott   DRUGS

OneBac 2.0:Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA

(2015) Mario Mietzsch et al.   HUMAN GENE THERAPY

Structure of neurotropic adeno-associated virus AAVrh.8

(2015) Sujata Halder et al.   JOURNAL OF STRUCTURAL BIOLOGY

Identification of an adeno-associated virus binding epitope for AVB sepharose affinity resin

(2015) Qiang Wang et al.   Molecular Therapy-Methods & Clinical Development

The structure of AAVrh32.33, a novel gene delivery vector

(2014) Kyle Mikals et al.   JOURNAL OF STRUCTURAL BIOLOGY

Phase I/II Trial of Adeno-Associated Virus–Mediated Alpha-Glucosidase Gene Therapy to the Diaphragm for Chronic Respiratory Failure in Pompe Disease: Initial Safety and Ventilatory Outcomes

(2013) Barbara K. Smith et al.   HUMAN GENE THERAPY

OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy

(2013) Mario Mietzsch et al.   HUMAN GENE THERAPY

Structural Insights into Adeno-Associated Virus Serotype 5

(2013) L. Govindasamy et al.   JOURNAL OF VIROLOGY

Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9

(2012) M. A. DiMattia et al.   JOURNAL OF VIROLOGY

Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20

(2012) Dustin M. McCraw et al.   VIROLOGY

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6

(2010) R. Ng et al.   JOURNAL OF VIROLOGY

The structure of adeno-associated virus serotype 3B (AAV-3B): Insights into receptor binding and immune evasion

(2010) Thomas F. Lerch et al.   VIROLOGY

A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells

(2009) Richard H Smith et al.   MOLECULAR THERAPY

Adeno-associated virus-2 and its primary cellular receptor—Cryo-EM structure of a heparin complex

(2009) Jason O'Donnell et al.   VIROLOGY