Article
Biochemistry & Molecular Biology
Martina Patone, Lahiru Handunnetthi, Defne Saatci, Jiafeng Pan, Srinivasa Vittal Katikireddi, Saif Razvi, David Hunt, Xue W. Mei, Sharon Dixon, Francesco Zaccardi, Kamlesh Khunti, Peter Watkinson, Carol A. C. Coupland, James Doidge, David A. Harrison, Rommel Ravanan, Aziz Sheikh, Chris Robertson, Julia Hippisley-Cox
Summary: Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to concerns in regulatory, clinical, and public health sectors. A self-controlled case series study in England showed an increased risk of rare neurological complications following COVID-19 vaccination and infection. The study highlighted a higher risk of Guillain-Barre syndrome after ChAdOx1nCoV-19 vaccination.
Article
Medicine, Research & Experimental
Pi -Ching Hsu, Md. Shahed-Al-Mahmud
Summary: The emergence of SARS-CoV-2 leads to COVID-19 by recognizing ACE2 and TMPRESS2 receptors, causing neurological complications in patients, particularly those with Parkinson's disease and Alzheimer's disease. Immune-mediated cytokines released during SARS-CoV-2 infection damage the central nervous system, resulting in a cytokine storm and CNS damage in COVID-19 patients.
Review
Pharmacology & Pharmacy
Waldemar Brola, Maciej Wilski
Summary: COVID-19 infection can lead to various neurological complications, including encephalopathy, meningitis, and stroke. Early symptoms often include olfactory and gustatory disorders, while severe neurological manifestations are relatively rare but increasing in number.
PHARMACOLOGICAL REPORTS
(2022)
Article
Neurosciences
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Nagaprasad Puvvada, Ramesh Kandimalla, P. Hemachandra Reddy
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to a year-long phase of public health adversaries and compromised healthcare globally. Understanding of neurological complications in COVID-19 patients is still limited, and factors such as age, sex, comorbidity, and disease severity play a role in exacerbating neurological manifestations in these patients.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Florian Gessler, Felix Lehmann, Julian Boesel, Hannah Fuhrer, Hermann Neugebauer, Katja E. Wartenberg, Stefan Wolf, Joshua D. Bernstock, Wolf-Dirk Niesen, Patrick Schuss
Summary: The survey of German neurointensivists on triage decisions during the COVID-19 pandemic revealed a positive attitude towards triage algorithms, with a strong belief that they should be involved in any institutional triage decisions due to the unique resources needed for treating patients within the Neuro ICU.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Biyan Nathanael Harapan, Hyeon Joo Yoo
Summary: The novel coronavirus SARS-CoV-2 causing COVID-19 has become a significant global challenge. In addition to respiratory symptoms, COVID-19 can also lead to neurological symptoms and complications. Further research is needed to understand the impact of neurological symptoms on the disease progression.
JOURNAL OF NEUROLOGY
(2021)
Editorial Material
Pediatrics
Walter S. Gilliam, Amyn A. Malik, Mehr Shafiq, Madeline Klotz, Chin Reyes, John Eric Humphries, Thomas Murray, Jad A. Elharake, David Wilkinson, Saad B. Omer
Summary: The study found that exposure to child care in the US during the early months of the pandemic did not increase the risk of COVID-19 transmission to providers. The findings emphasize the importance of infection mitigation efforts in child care programs.
Article
Clinical Neurology
Ettore Beghi, Raimund Helbok, Michael Crean, Sherry Hsiang-Yi Chou, Molly McNett, Elena Moro, Claudio Bassetti
Summary: The COVID-19 pandemic has led to neurological complications in up to one-third of cases, with varying prevalence, incidence, and characteristics. The ENERGY international registry was created to better understand the neurological manifestations and outcomes of COVID-19 infections.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Sofia Portela-Sanchez, Antonio Sanchez-Soblechero, Pedro Jose Melgarejo Otalora, Angela Rodriguez Lopez, Gabriel Velilla Alonso, Michael Armando Palacios-Mendoza, Carlos Catedra Carame, Laura Amaya Pascasio, Miguel Mas Serrano, Andreu Massot-Tarrus, Beatriz De La Casa-Fages, Fernando Diaz-Otero, Irene Catalina, Jose Manuel Garcia Dominguez, Javier Ricardo Perez-Sanchez, Jose Luis Munoz-Blanco, Francisco Grandas
Summary: This study described the spectrum of neurological complications in COVID-19 patients requiring a neurological assessment, with only 2.6% of hospitalized patients experiencing at least one complication. The most common diagnoses were neuromuscular disorders, cerebrovascular diseases, acute encephalopathy, and seizures. Mortality was higher in the cerebrovascular diseases group.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Biology
Zahra Ghotbi, Mehrdad Estakhr, Melika Hosseini, Reza Bavarsad Shahripour
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Endothelial dysfunction and cerebral vasomotor reactivity (VMR) impairment occur in COVID-19 patients, which is associated with a higher risk of severe disease and poor outcomes. Viruses such as Human Herpes Virus 8 and Hantavirus predominantly affect endothelial cells and impact cerebral hemodynamics. Understanding VMR can provide valuable insights for disease progression and treatment decisions in COVID-19 patients.
Review
Chemistry, Medicinal
Faezeh Almasi, Wen Dang, Fatemeh Mohammadipanah, Ning Li
Summary: In addition to respiratory symptoms, COVID-19 can also lead to various neurological disorders. Despite the growing research on the neurological aspects of COVID-19, the underlying mechanisms and therapeutic methods are still unclear. However, some natural compounds have shown neuroprotective effects and could be potential drugs for treating neurological complications of SARS-CoV-2.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Review
Immunology
Yoshitaka Kase, Hideyuki Okano
Summary: Since the outbreak of COVID-19 in 2020, research reports have shown that the virus causes not only respiratory disorders, but also various neural disorders. However, there has been relatively limited research and summaries on COVID-19-related neural disorders compared to other illnesses caused by the virus.
INFLAMMATION AND REGENERATION
(2021)
Article
Biology
William L. Hamilton, Gerry Tonkin-Hill, Emily R. Smith, Dinesh Aggarwal, Charlotte J. Houldcroft, Ben Warne, Luke W. Meredith, Myra Hosmillo, Aminu S. Jahun, Martin D. Curran, Surendra Parmar, Laura G. Caller, Sarah L. Caddy, Fahad A. Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Malte L. Pinckert, Iliana Georgana, Yasmin Chaudhry, Colin S. Brown, Sonia Goncalves, Roberto Amato, Ewan M. Harrison, Nicholas M. Brown, Mathew A. Beale, Michael Spencer Chapman, David K. Jackson, Ian Johnston, Alex Alderton, John Sillitoe, Cordelia Langford, Gordon Dougan, Sharon J. Peacock, Dominic P. Kwiatowski, Ian G. Goodfellow, M. Estee Torok
Summary: COVID-19 poses significant challenges in care homes due to high mortality rates and varied patterns of viral transmission. Limiting viral spread within care homes is crucial to reducing COVID-19 mortality in this population.
Article
Chemistry, Analytical
Yong Luo, Mengyun Zhou, Chuan Fan, Yongchao Song, Lirong Wang, Tailin Xu, Xueji Zhang
Summary: This paper reports an integrated active enrichment platform for direct hand-held detection of COVID-19 nucleic acid in nanoliter samples without PCR. The platform comprises a capillary-assisted liquid-carrying system for sampling, an integrated circuit system for ultrasound output, and a cell-phone-based surface-enhanced Raman scattering (SERS) system. With the use of functionalized gold nanorods, this platform can actively assemble gold nanorods and achieve highly sensitive SERS detection of COVID-19 biomarkers in nanoliter samples within 5 minutes. The platform demonstrates high stability, repeatability, and selectivity, and shows potential for the detection of throat swab samples, making it a promising diagnostic tool for direct and rapid COVID-19 detection.
ANALYTICAL CHEMISTRY
(2023)
Editorial Material
Neurosciences
Abdul Mannan Baig
Summary: Long-COVID patients are showing persistent and ominous neurological deficits that lead to disabilities, with the mechanisms behind these symptoms still unclear. Factors such as viral load location, differential immune response, neurodegenerative changes, and inflammation are debated as potential causative factors that need further investigation for understanding the pathogenesis of neuro-COVID in long-COVID syndrome.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Anesthesiology
Denise Battaglini, Lavienraj Premraj, Samuel Huth, Jonathon Fanning, Glenn Whitman, Rakesh C. Arora, Judith Bellapart, Diego Bastos Porto, Fabio S. Taccone, Jacky Y. Suen, Gianluigi Li Bassi, John F. Fraser, Sung-Min Cho, Chiara Robba
Summary: This systematic review investigates the use of noninvasive multimodal neuromonitoring in critically ill adult patients with COVID-19. The findings suggest that alterations in cerebral hemodynamics, brain compliance, brain oxygenation, pupillary response, and brain electrophysiological activity are common in these patients, but they are not clearly associated with worse outcome or the development of new neurological complications.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2023)
Article
Anesthesiology
Christoph Boesing, Laura Schaefer, Marvin Hammel, Mirko Otto, Susanne Blank, Paolo Pelosi, Patricia R. M. Rocco, Thomas Luecke, Joerg Krebs
Summary: This study compared the end-expiratory transpulmonary pressure between fixed and individualized positive end-expiratory pressure (PEEP) strategies in superobese patients and analyzed their effects on respiratory mechanics, end-expiratory lung volume, gas exchange, and hemodynamic parameters. The study found that individualized PEEP strategy resulted in lower end-expiratory transpulmonary pressure while improving respiratory mechanics, lung volume, and oxygenation. Therefore, individualized PEEP strategy may be a feasible approach for respiratory support in superobese patients undergoing laparoscopic surgery.
Article
Medicine, General & Internal
Daniele Roberto Giacobbe, Emilio Di Maria, Alberto Stefano Tagliafico, Martina Bavastro, Carlo Simone Trombetta, Cristina Marelli, Gabriele Di Meco, Greta Cattardico, Sara Mora, Alessio Signori, Antonio Vena, Malgorzata Mikulska, Chiara Dentone, Bianca Bruzzone, Bianca Bignotti, Andrea Orsi, Chiara Robba, Lorenzo Ball, Iole Brunetti, Denise Battaglini, Antonio Di Biagio, Maria Pia Sormani, Paolo Pelosi, Mauro Giacomini, Giancarlo Icardi, Matteo Bassetti
Summary: This study validated the prognostic value of the FEN-COVID-19 phenotyping system in hospitalized COVID-19 patients and assessed the reproducibility of phenotypes development. The results showed that patients assigned to phenotype C had a higher mortality rate compared to phenotypes A and B.
ANNALS OF MEDICINE
(2023)
Article
Infectious Diseases
Giulia Codda, Edward Willison, Laura Magnasco, Paola Morici, Daniele Roberto Giacobbe, Antonella Mencacci, Daniele Marini, Malgorzata Mikulska, Matteo Bassetti, Anna Marchese, Vincenzo Di Pilato
Summary: A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of FKS1S639F and FKS1F635Y mutants upon prolonged exposure to caspofungin and/or anidulafungin.
Article
Medicine, General & Internal
Amedeo Tirandi, Eleonora Arboscello, Stefano Ministrini, Luca Liberale, Aldo Bonaventura, Alessandra Vecchie, Maria Bertolotto, Daniele Roberto Giacobbe, Luca Castellani, Michele Mirabella, Silvia Minetti, Matteo Bassetti, Fabrizio Montecucco, Federico Carbone
Summary: In this pilot study, SOST levels were found to be associated with age, cardiovascular comorbidities, and early death in septic patients. SOST showed a high predictive value for 30-day mortality and outperformed validated scoring scales for critically ill patients. The variation in SOST levels also predicted long-term mortality.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Respiratory System
Jorge Luis Velez-Paez, Santiago Xavier Aguayo-Moscoso, Christian Castro-Bustamante, Mario Montalvo-Villagomez, Fernando Jara-Gonzalez, Lucy Baldeon-Rojas, Natalia Zubieta-DeUrioste, Denise Battaglini, Gustavo R. Zubieta-Calleja
Summary: This study aimed to compare the survival rate of obese patients with COVID-19 at high altitude with overweight and normal patients. The results showed that obese patients had a lower mortality rate, but it was not statistically significant compared to overweight and normal patients. Age was an independent risk factor for mortality. In high-altitude areas, obese patients had higher pulmonary artery pressure and mechanical power, but a lower extubation failure rate.
BMC PULMONARY MEDICINE
(2023)
Biographical-Item
Critical Care Medicine
Patricia R. M. Rocco
ANNALS OF INTENSIVE CARE
(2023)
Article
Physiology
Alberto Giardina, Danilo Cardim, Pietro Ciliberti, Denise Battaglini, Lorenzo Ball, Magdalena Kasprowicz, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Shirin Frisvold, Matjaz Groznik, Paolo Pelosi, Chiara Robba
Summary: This study aims to assess the effect of increasing positive end-expiratory pressure (PEEP) on cerebral autoregulation in brain injured patients. The results showed that increasing PEEP did not worsen cerebral autoregulation and did not require clinical intervention.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Pietro Ciliberti, Danilo Cardim, Alberto Giardina, Matjaz Groznik, Lorenzo Ball, Martina Giovannini, Denise Battaglini, Erta Beqiri, Basil Matta, Peter Smielewski, Marek Czosnyka, Paolo Pelosi, Chiara Robba
Summary: This study aims to assess the effects of hyperoxygenation and hyperoxemia on cerebral autoregulation in acute brain injured patients. The results suggest that short-term hyperoxygenation does not critically affect cerebral autoregulation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Debora P. Ferreira, Sabrina V. Martini, Helena A. Oliveira, Adriana L. Silva, Siddharth Shenoy, Daiqin Chen, Valentina Simon, Eric Han, Natalie E. West, Jung Soo Suk, Patricia R. M. Rocco, Hilda Petrs-Silva, Marcelo M. Morales, Fernanda F. Cruz
Summary: This study successfully demonstrated the effective delivery of gene therapy to the lung using a mutant AAV8 vector, which showed high efficiency in penetrating mucus. The transfer of the PEDF gene did not have any adverse effects on lung parameters, providing a basis for further research on PEDF gene therapy.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Infectious Diseases
Ivan Gentile, Antonio Riccardo Buonomo, Silvia Corcione, Laurenza Paradiso, Daniele Roberto Giacobbe, Davide Fiore Bavaro, Giusy Tiseo, Francesca Sordella, Michele Bartoletti, Giulia Palmiero, Antonietta Vozza, Antonio Vena, Francesca Canta, Nicola Schiano Moriello, Paola Congera, Arta Karruli, Carlo Tascini, Pierluigi Viale, Valerio Del Bono, Marco Falcone, Sergio Carbonara, Malgorzata Karolina Mikulskan, Matteo Bassettie, Emanuele Durante-Mangonid, Francesco Giuseppe De Rosa, Alberto Enrico Maraolo
Summary: This study evaluated the use of Ceftobiprole in a real-world setting and found it to be a safe and effective therapeutic choice, particularly for pneumonia and hospital-acquired pneumonia. The study also identified factors associated with treatment success or fatal outcomes.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Anesthesiology
Denise Battaglini, Lara Delpiano, Denise Masuello, Pedro Leme Silva, Patricia R. M. Rocco, Basil Matta, Paolo Pelosi, Chiara Robba
Summary: The aim of this study was to evaluate the effects of PEEP augmentation test on brain oxygenation, systemic oxygen cascade, and metabolism in patients with acute brain injury. The results showed that PEEP augmentation test did not affect cerebral oxygenation, systemic oxygen cascade parameters, and metabolism.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Letter
Clinical Neurology
Denise Battaglini, Nicole M. White, Lavienraj Premraj, Barbara Wanjiru Citarella, Laura Merson, Chiara Robba, David Thomson, Sung-Min Cho
JOURNAL OF NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Denise Battaglini, Ida Giorgia Iavarone, Lou'i Al-Husinat, Lorenzo Ball, Chiara Robba, Pedro Leme Silva, Fernanda F. Cruz, Patricia R. M. Rocco
Summary: Despite progress in pharmacotherapy, anti-inflammatory strategies for ARDS treatment remain controversial. However, personalized medicine may be a promising approach for identifying specific subgroups that may benefit from anti-inflammatory treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Critical Care Medicine
Christoph Boesing, Laura Schaefer, Peter T. Graf, Paolo Pelosi, Patricia R. M. Rocco, Thomas Luecke, Joerg Krebs
Summary: In ARDS patients treated with VV ECMO, adjusting PEEP to 10 cmH(2)O can reduce MP, improve hemodynamic parameters, and increase oxygen delivery.
JOURNAL OF CRITICAL CARE
(2024)
