Chemotherapy‐Enriched THBS2‐Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

(2019) William Y. Wang et al.   Nature Communications

A Soft Matrix Enhances the Cancer Stem Cell Phenotype of HCC Cells

(2019) Boren Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction

(2019) Heloísa Gerardo et al.   Scientific Reports

Matrix stiffening and EGFR cooperate to promote the collective invasion of cancer cells.

(2018) Eloise M Grasset et al.   CANCER RESEARCH

Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib

(2018) Man Tong et al.   JOURNAL OF HEPATOLOGY

RAR-β is downregulated in HCC & cirrhosis and its expression inhibits myosin-driven activation and durotaxis in hepatic stellate cells

(2018) Ernesto Cortes et al.   HEPATOLOGY

Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells

(2018) Fengbo Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop

(2018) Jun Wang et al.   NATURE NEUROSCIENCE

PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation

(2018) Lok Hei Chan et al.   Cell Reports

Low-level shear stress induces differentiation of liver cancer stem cells via the Wnt/β-catenin signalling pathway

(2018) Jinghui Sun et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-20a regulates cell proliferation, apoptosis and autophagy by targeting thrombospondin 2 in cervical cancer

(2018) Qinghong Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fluid shear stress induces cancer stem cell-like phenotype in MCF7 breast cancer cell line without inducing epithelial to mesenchymal transition

(2017) Ursula L. Triantafillu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro

(2017) Kenichiro Motomura et al.   PLoS One

MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2

(2017) Wen-Fei Wei et al.   Cell Death & Disease

Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells

(2016) Mei-Fong Pang et al.   CANCER RESEARCH

Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells

(2016) Stella Chai et al.   HEPATOLOGY

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells

(2016) Yang You et al.   Oncotarget

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Increasing matrix stiffness upregulates vascular endothelial growth factor expression in hepatocellular carcinoma cells mediated by integrin β1

(2014) Yinying Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening

(2014) Thuy V. Nguyen et al.   BIOMATERIALS

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

(2014) Youhua Tan et al.   Nature Communications

Cancer stem cells in the development of liver cancer

(2013) Taro Yamashita et al.   JOURNAL OF CLINICAL INVESTIGATION

Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

The nanomechanical signature of breast cancer

(2012) Marija Plodinec et al.   Nature Nanotechnology

Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior

(2012) Robert S Fischer et al.   Nature Protocols

AFM-Detected Apoptotic Changes in Morphology and Biophysical Property Caused by Paclitaxel in Ishikawa and HeLa Cells

(2012) Kyung Sook Kim et al.   PLoS One

Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts

(2011) Antonio Mazzocca et al.   HEPATOLOGY

miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1

(2010) Stephanie Ma et al.   Cell Stem Cell

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography

(2009) Ryota Masuzaki et al.   HEPATOLOGY

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Thrombospondin-2 Modulates Extracellular Matrix Remodeling during Physiological Angiogenesis

(2008) Marie M. Krady et al.   AMERICAN JOURNAL OF PATHOLOGY

Thrombospondins: from structure to therapeutics

(2008) S. Kazerounian et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stem Cell Niche: Microenvironment and Beyond

(2008) Jiwang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY