Article
Oncology
Qiankun Li, Wenjing Yue, Ming Li, Zhipeng Jiang, Zehui Hou, Wei Liu, Ning Ma, Wenchang Gan, Yingru Li, Taicheng Zhou, Wenjing Yue, Shuang Chen
Summary: CTBP1-AS2 is significantly overexpressed in CRC tissues and is associated with worse survival. Functional experiments showed that CTBP1-AS2 accelerates CRC cell proliferation and invasion, inhibits apoptosis, and regulates the malignant phenotype of tumor cells through the TGF-beta/SMAD2/3 pathway. Additionally, miR-93-5p acts as an endogenous competitive RNA of CTBP1-AS2, attenuating its oncogenic effects.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Wang, Junli Dong, Jun Ma, Qin Lu, Ben Shan, Tingting Han, Peng Xie, Xiaohua Zuo
Summary: miR-18a-3p targets ADCY5 to promote osteoporosis and may be involved in spinal fractures. OE-ADCY5 significantly enhances osteoblast activity and protein expression, while miR-18a-3p mimic inhibits this process.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Aparna Cherukunnath, Ravichandra S. Davargaon, Rahail Ashraf, Urja Kamdar, Amit K. Srivastava, Prem P. Tripathi, Nabanita Chatterjee, Sanjay Kumar
Summary: KLF8 is overexpressed in ovarian cancer and promotes cancer progression. TGF-beta 1 activates KLF8 expression through the Smad2 pathway and regulates epithelial-mesenchymal transition (EMT), contributing to OC progression.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Cell Biology
Tsung-Lin Cheng, Chung-Hwan Chen, Meng-Hsing Wu, Chao-Han Lai, Ko-Hung Lee, Sheng-Hsiang Lin, Ai-Li Shiau, Chao-Liang Wu, Lin Kang
Summary: The study found that levels of FGL1 protein in serum and placenta were significantly upregulated in patients and mice with PE. FGL1 treatment decreased maternal hypertension and proteinuria, decreased fetal weight in PE mice, downregulated proinflammatory cytokine levels, and maintained the balance between antiangiogenic and proangiogenic substances in the placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ya-Li Zhang, Liang Liu, Yu-Wen Su, Cory J. Xian
Summary: miR-6315 plays a role in promoting osteogenesis and reducing MTX-induced adipogenesis, potentially through modulation of the TGF-beta/Smad2 signaling pathway in regulating osteogenesis/adipogenesis. The study suggests that miR-6315 may be important in regulating osteogenesis and adipogenesis, serving as a therapeutic target for preventing/attenuating MTX treatment-associated bone loss and marrow adiposity.
Article
Biochemistry & Molecular Biology
Xiaonian Guan, Ming Yu, Linlin Wu, Jie Chen, Jianing Tong, Xiaoxia Wu, Aiqi Yin, Tianxia Xiao, Baobei Wang, Jian Zhang, Jianmin Niu
Summary: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. This study found that overexpression of Siglec6 in placental trophoblasts is associated with the development of preeclampsia. Siglec6 impairs the function of vascular endothelial cells by downregulating the Wnt6/β-catenin signaling pathway.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Endocrinology & Metabolism
Yanan Shan, Yan Chen, Jelena Brkic, Leslie Fournier, Haiying Ma, Chun Peng
Summary: miR-218-5p inhibits the TGF-β/SMAD2 pathway to induce IL1β expression and promote enEVT differentiation. IL1β, in turn, inhibits the expression of miR-218-5p, forming a negative feedback regulatory loop.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Nanees Fouad El-Malkey, Mohammed Aref, Hassan Emam, Sama Salah Khalil
Summary: This study found that melatonin significantly improved the fetal neuroprotective effect in pregnant rats, including increasing placental, fetal, and brain weight, reducing fetal death rate, increasing related growth factors and antioxidant enzymes, and decreasing pro-inflammatory factors. Furthermore, neurohistological study also supported the neuroprotective effect of melatonin on the fetal cerebral cortex in rats.
REPRODUCTIVE SCIENCES
(2021)
Article
Plant Sciences
Meng-yuan Qin, Song-qing Huang, Xiao-qin Zou, Xiao-bin Zhong, Yu-fang Yang, Yu-ting Zhang, Zheng-cheng Mi, Yan-song Zhang, Zhen-guang Huang
Summary: The study found that the drug-containing serum of rhubarb-astragalus can effectively inhibit the epithelial-mesenchymal transformation of HK-2 cells, and achieve this effect by downregulating the TGF-fi1/p38 MAPK/Smad2/3 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Min Wang, Hailiang Zhao, Weiwei Chen, Caiqun Bie, Jinying Yang, Wenrui Cai, Hutian Wu, Yanfang Chen, Shufen Feng, Ying Shi, Yuting Li, Huijun Tang, Lixian Zhong, Liliangzi Guo, Sisi Chen, Linjing Long, Shaohui Tang
Summary: The dysregulation of exosomal microRNA miR-4256 plays a crucial role in gastric cancer (GC) development and progression. In vitro and in vivo experiments demonstrate that miR-4256 promotes GC growth and progression by enhancing HDAC5 expression and suppressing p16INK4a expression. Furthermore, miR-4256 overexpression is positively regulated by the SMAD2/p300 complex in GC cells. Overall, miR-4256 functions as an oncogene via the SMAD2/miR-4256/HDAC5/p16INK4a axis, providing novel therapeutic and prognostic biomarkers for GC.
Article
Biochemistry & Molecular Biology
Weidi Zhang, Wenzhi Ren, Dongxu Han, Guokun Zhao, Haoqi Wang, Haixiang Guo, Yi Zheng, Zhonghao Ji, Wei Gao, Bao Yuan
Summary: In this study, a new lncRNA, named lncRNA-m18as1, was identified and found to regulate the synthesis and secretion of FSH by interacting with miR-18a-5p and Smad2. This research reveals the important function and regulatory mechanism of lncRNA in pituitary cells.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Pharmacology & Pharmacy
Xingsheng Lin, Wenhao Lin, Yingfeng Zhuang, Fengying Gao
Summary: This study found that ACE2 can inhibit the epithelial-mesenchymal transition and lung fibrosis in lung type II epithelial cells, and it may do so by regulating the TGF-#1/Smad2/Smad3 pathway.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Developmental Biology
Yali Deng, Weisi Lai, Ling Yu, Wen Zhang, Yiling Ding
Summary: In this study, it was found that miR-2115-3p may interact with GOT1 mRNA to downregulate its expression, further inhibiting hypoxia-induced ferroptosis in a PE model.
Article
Biochemistry & Molecular Biology
Yijie Gao, Mengdan Shi, Min Liu, Lingyun Liao, Xiaohong Wei, Yangxue Yin, Rong Zhou
Summary: This study investigated the biological function and mechanism of miR-95-3p in preeclampsia (PE). The results revealed that miR-95-3p was expressed at low levels in PE placental tissue and negatively correlated with EPM2A expression. Upregulation of miR-95-3p and downregulation of EPM2A promoted trophoblast migration and invasion, and both miR-95-3p and EPM2A regulated the expression of angiogenesis-related factors and inflammation-related factors.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biotechnology & Applied Microbiology
Meng Zhao, Junli Dong, Yuanmei Liao, Guoyong Lu, Wei Pan, Hansong Zhou, Xiaohua Zuo, Ben Shan
Summary: miR-18a-3p promotes the progression of osteoporosis by regulating the expression of GRIA1, and upregulation of miR-18a-3p inhibits osteoblast differentiation and calcium deposition.
Article
Obstetrics & Gynecology
Xueju Wang, Luyao Li, Pengbo Yuan, Yangyu Zhao, Yuan Wei
Summary: Placental territory discordance and velamentous umbilical cord insertion may be causes of TTTS with sIUGR. Compared with TTTS without sIUGR, TTTS with sIUGR had a higher prevalence of protective AA anastomoses in the placenta.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Xueju Wang, Luyao Li, Pengbo Yuan, Yangyu Zhao, Yuan Wei
Summary: This study compared the placental features between selective intrauterine growth restriction (sIUGR) patients with dynamic classification (DC) and stable classifications (SC). The results showed that the prevalence of large artery-artery anastomosis (AAA) was significantly higher in sIUGR patients with DC than those with SC. Additionally, sIUGR patients with DC had a smaller total number of artery-vein anastomosis and a higher incidence of neonatal asphyxias.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Yuanyuan Wang, Yadan Zhou, Lin Zeng, Lian Chen, Yangyu Zhao
Summary: This retrospective study analyzed relevant factors for massive postpartum hemorrhage in women with placenta accreta spectrum. It found that the presence of cervical blood sinus, interruption or disappearance of bladder line, the disappearance of the post-placental clear space, and abnormal subplacental vascularity are independent risk factors for massive hemorrhage during PAS. Paying attention to these indicators in prenatal ultrasound examination can reduce intraoperative bleeding and improve maternal outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Xueju Wang, Luyao Li, Pengbo Yuan, Yangyu Zhao, Yuan Wei
Summary: Thick arterio-arterial anastomosis (AAA) can coexist with thick arterio-venous anastomosis (AVA) and thick veno-venous anastomosis (VVA) in cases of selective fetal growth restriction (sFGR), and placental angiogenesis may differ significantly based on the presence of thick AAA. Growth-restricted fetuses with thick AAA have larger birth weights compared to cases without thick AAA.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Huifeng Shi, Lian Chen, Yuanyuan Wang, Mengxing Sun, Yijie Guo, Shang Ma, Xiaoli Wang, Hai Jiang, Xiaoxia Wang, Jie Lu, Lin Ge, Shu Dong, Yu Zhuang, Yangyu Zhao, Yuan Wei, Xudong Ma, Jie Qiao
Summary: Anemia during pregnancy, with varying severity, is associated with increased risks of adverse maternal and fetal outcomes. Mild anemia is linked to improved maternal and fetal survival, as well as fetal growth. Further research is needed to determine the optimal hemoglobin concentration for maternal and fetal health.
Letter
Medicine, General & Internal
Yuxin Ran, Ruixin Chen, Yangyu Zhao, Nanlin Yin, Hongbo Qi
Summary: Efforts to find stable cell-free fetal RNA in maternal circulation for non-invasive prenatal testing (NIPT) have become urgent. This study discovered the presence of fetal circRNA in the peripheral blood of pregnant women, which persisted even after delivery for at least 24 hours. Furthermore, it was found that cff-circRNA might have specific expression patterns in gestational diseases. These findings may contribute to the development of NIPT.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Reproductive Biology
Xuan Shao, Wenzhe Yu, Yun Yang, Feiyang Wang, Xin Yu, Hongyu Wu, Yeling Ma, Bin Cao, Yan-Ling Wang
Summary: This article summarizes the important role of the placenta during pregnancy, discusses the mechanisms underlying the formation of placental functional units and the placental defense against pathogen infections. Additionally, it explores the association between placental dysregulation and adverse pregnancy outcomes.
BIOLOGY OF REPRODUCTION
(2022)
Article
Genetics & Heredity
Xinlu Meng, Ying Wang, Pengbo Yuan, Xueju Wang, Shaohua Yin, Huifeng Shi, Xiaoli Gong, Yangyu Zhao, Yuan Wei
Summary: This study compares the outcomes of expectant management and fetal reduction to twins in monochorionic triamniotic triplets. The results suggest that reducing to twins can reduce the risk of preterm birth, but expectant management may be a reasonable choice to ensure at least one survivor.
PRENATAL DIAGNOSIS
(2022)
Article
Obstetrics & Gynecology
Ying Wang, Huifeng Shi, Xueju Wang, Pengbo Yuan, Yuan Wei, Yangyu Zhao
Summary: This study aimed to identify selective fetal growth restriction (sFGR) in monochorionic twin (MCT) pregnancy with expectant management. Early-onset sFGR had a poorer survival of at least one or both twins, but there was no statistical difference in the prognosis after live birth, neither for fetal growth restriction (FGR) babies nor those of appropriate growth for gestational age (AGA). Superimposed twin-twin transfusion syndrome (TTTS) and Types Il/III sFGR had a worse perinatal outcome.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2022)
Article
Nutrition & Dietetics
Haitian Chen, Hailin Li, Yinli Cao, Hongbo Qi, Yuyan Ma, Xiaoxia Bai, Yangyu Zhao, Li Wu, Caixia Liu, Jun Wei, Hong Wang, Yan Jin, Zilian Wang, Yanna Zhu
Summary: Under more severe COVID-19 pandemic conditions, pregnant women consumed less quality food, characterized by reduced consumption of vegetables, fruit, livestock/poultry meat, dairy and nuts, while the quality of the foods that pregnant women consumed in excess tended to improve, but the overconsumption of cereals/potatoes was a problem.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Xiaoying Rong, Jie Zhang, Yangyu Zhao, Lixiang Xue, Xiangyang Guo, Mingya Wang, Qian Xiang, Hong Zeng
Summary: This study indicates that a shift away from Th2 bias in amniotic fluid and circulating CD4(+) T cells is involved in the pathogenesis of preeclampsia. Restoring the Th2 bias in amniotic fluid might be a therapeutic target for preeclampsia.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Huifeng Shi, Xiaoli Gong, Qing Sheng, Xiang Li, Ying Wang, Tianchen Wu, Yangyu Zhao, Yuan Wei
Summary: This study found an association between vitamin E (VE) levels and gestational diabetes mellitus (GDM) in pregnant women. Low first-trimester VE levels and subsequent decrease in VE during pregnancy were related to increased risk of GDM. These findings suggest the importance of consuming VE-rich foods and appropriate VE supplementation to prevent GDM in pregnant women with low baseline VE levels.
Letter
Cell Biology
Liyuan Jiang, Xin Wang, Leyun Wang, Sinan Ma, Yali Ding, Chao Liu, Siqi Wang, Xuan Shao, Ying Zhang, Zhikun Li, Wei Li, Guihai Feng, Qi Zhou
Article
Endocrinology & Metabolism
Xuan Shao, Yun Yang, Yanlei Liu, Yongqing Wang, Yangyu Zhao, Xin Yu, Juan Liu, Yu-Xia Li, Yan-Ling Wang
Summary: Maintaining placental endocrine homeostasis is crucial for a successful pregnancy. Aberrant elevation of testosterone (T0) synthesis, reduced estradiol (E2), and melatonin productions have been identified in preeclamptic placentas. This study reveals an orchestrated feedback mechanism that maintains homeostasis of placental sex hormones and melatonin, and offers novel evidence that identifies potential targets for the development of innovative therapeutic strategies for PE.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Obstetrics & Gynecology
Xin Yu, Hongyu Wu, Yun Yang, Feiyang Wang, Yan-Ling Wang, Xuan Shao
Summary: The placenta serves as the interface between the fetal and maternal environments, playing critical roles in protecting the developing fetus and maintaining maternal health. Defects in placental development and function are closely associated with adverse pregnancy outcomes. Understanding the differentiation of trophoblast cells and the formation of placental functional units is important for studying pregnancy-related disorders such as preeclampsia.
MATERNAL-FETAL MEDICINE
(2022)
