Essential Functions of the Transcription Factor Npas4 in Neural Circuit Development, Plasticity, and Diseases

Maternal Separation Early in Life Alters the Expression of Genes Npas4 and Nr1d1 in Adult Female Mice: Correlation with Social Behavior

(2020) Yuliya A. Ryabushkina et al.   BEHAVIOURAL NEUROLOGY

Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4

(2020) Benjamin Rein et al.   MOLECULAR PSYCHIATRY

Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses

(2020) Keiko Unno et al.   Nutrients

Functionally Distinct Neuronal Ensembles within the Memory Engram

(2020) Xiaochen Sun et al.   CELL

Cognitive appraisal in fish: stressor predictability modulates the physiological and neurobehavioural stress response in sea bass

(2020) M. Cerqueira et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release

(2020) Rémi Opsomer et al.   eNeuro

ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation

(2019) Nikhil Sharma et al.   NEURON

Modulation of neuroplasticity-related targets following stress-induced acute escape deficit

(2019) C. Benatti et al.   BEHAVIOURAL BRAIN RESEARCH

Dysregulation of miR-142 results in anxiety-like behaviors following single prolonged stress

(2019) Li-Li Ji et al.   BEHAVIOURAL BRAIN RESEARCH

Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus

(2019) Jordi Fernandez-Albert et al.   NATURE NEUROSCIENCE

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

(2019) Anto Sam Crosslee Louis Sam Titus et al.   BMC NEUROSCIENCE

Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

(2019) Yasuhiro Funahashi et al.   Cell Reports

Activation of immediate early genes by nicotine after chronic neonatal nicotine exposure in brain areas involved in stress and anxiety responses

(2018) Amal A. Halawa et al.   BRAIN RESEARCH

Npas4 deficiency and prenatal stress interact to affect social recognition in mice

(2018) K. Heslin et al.   GENES BRAIN AND BEHAVIOR

Multiple sequences orchestrate subcellular trafficking of neuronal PAS domain–containing protein 4 (NPAS4)

(2018) Beata Greb-Markiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression of the immediate early genes c-Fos , Arc , Egr-1 , and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE)

(2018) Nicholas A. Heroux et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

(2018) Feng-Ju Weng et al.   NEURON

Structural insights and characterization of human Npas4 protein

(2018) Ammad Fahim et al.   PeerJ

Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis

(2018) Tissa Rahim et al.   Journal of Neuroinflammation

Post-injury Nose-to-Brain Delivery of Activin A and SerpinB2 Reduces Brain Damage in a Mouse Stroke Model

(2018) Bettina Buchthal et al.   MOLECULAR THERAPY

NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus

(2018) Andrea L Hartzell et al.   eLife

Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates

(2018) Qin Wang et al.   Science Advances

Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a

(2017) Wei Shan et al.   JOURNAL OF NEUROCHEMISTRY

HDAC5 and Its Target Gene, Npas4 , Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors

(2017) Makoto Taniguchi et al.   NEURON

Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration

(2016) Anne M.H. Woitecki et al.   JOURNAL OF NEUROSCIENCE

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

(2016) Jana Drgonova et al.   MOLECULAR MEDICINE

Npas4: Linking Neuronal Activity to Memory

(2016) Xiaochen Sun et al.   TRENDS IN NEUROSCIENCES

Social Plasticity Relies on Different Neuroplasticity Mechanisms across the Brain Social Decision-Making Network in Zebrafish

(2016) Magda C. Teles et al.   Frontiers in Behavioral Neuroscience

Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour

(2015) Emily J. Jaehne et al.   BEHAVIOURAL BRAIN RESEARCH

The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia

(2015) Fong Choy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reduction of the neuroprotective transcription factor Npas4 results in increased neuronal necrosis, inflammation and brain lesion size following ischaemia

(2015) Fong Chan Choy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Genes associated with the progression of neurofibrillary tangles in Alzheimer’s disease

(2015) A Miyashita et al.   Translational Psychiatry

Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs

(2014) Ivo Spiegel et al.   CELL

Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain

(2014) Thomas Klarić et al.   Frontiers in Neuroanatomy

Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons

(2014) Sei-ichi Yoshihara et al.   Cell Reports

Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

(2013) David C. Bersten et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Upregulation of the neuronal Per-Arnt-Sim domain protein 4 (Npas4) in the rat corticolimbic system following focal cerebral ischemia

(2013) Wai Khay Leong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

(2013) Brenda L. Bloodgood et al.   NATURE

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Experience-dependent expression ofNPAS4regulates plasticity in adult visual cortex

(2012) José Fernando Maya-Vetencourt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Upregulation of Npas4 protein expression by chronic administration of amphetamine in rat nucleus accumbens in vivo

(2012) Ming-Lei Guo et al.   NEUROSCIENCE LETTERS

Methamphetamine Causes Differential Alterations in Gene Expression and Patterns of Histone Acetylation/Hypoacetylation in the Rat Nucleus Accumbens

(2012) Tracey A. Martin et al.   PLoS One

The Neuronal PAS Domain Protein 4 (Npas4) Is Required for New and Reactivated Fear Memories

(2011) Jonathan E. Ploski et al.   PLoS One

Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation

(2011) K. Ramamoorthi et al.   SCIENCE

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4

(2010) Jaesuk Yun et al.   JOURNAL OF NEUROCHEMISTRY

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE