Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids

Δ9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons

(2020) Carole Shum et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

An integrated pipeline for high-throughput screening and profiling of spheroids using simple live image analysis of frame to frame variations

(2020) Haneen Alsehli et al.   METHODS

Prenatal Origins of ASD: The When, What, and How of ASD Development

(2020) Eric Courchesne et al.   TRENDS IN NEUROSCIENCES

Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals

(2020) Dwaipayan Adhya et al.   BIOLOGICAL PSYCHIATRY

Planar Airy beam light-sheet for two-photon microscopy

(2020) Neveen A. Hosny et al.   Biomedical Optics Express

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

(2019) Simon T. Schafer et al.   NATURE NEUROSCIENCE

Disease modelling in human organoids

(2019) Madeline A. Lancaster et al.   Disease Models & Mechanisms

Fast 3-D Imaging of Brain Organoids With a New Single-Objective Planar-Illumination Two-Photon Microscope

(2019) Irina Rakotoson et al.   Frontiers in Neuroanatomy

Calcium signaling mediates five types of cell morphological changes to form neural rosettes

(2018) Hana Hříbková et al.   JOURNAL OF CELL SCIENCE

Imaging organoids: a bright future ahead

(2018) Anne C Rios et al.   NATURE METHODS

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Engineering induction of singular neural rosette emergence within hPSC-derived tissues

(2018) Gavin T Knight et al.   eLife

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Dynamic behaviour of human neuroepithelial cells in the developing forebrain

(2017) Lakshmi Subramanian et al.   Nature Communications

Fast free-of-acrylamide clearing tissue (FACT)—an optimized new protocol for rapid, high-resolution imaging of three-dimensional brain tissue

(2017) Na Xu et al.   Scientific Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

(2016) Tomoki Otani et al.   Cell Stem Cell

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

(2016) M C Marchetto et al.   MOLECULAR PSYCHIATRY

Enhancement of image quality and imaging depth with Airy light-sheet microscopy in cleared and non-cleared neural tissue

(2016) Jonathan Nylk et al.   Biomedical Optics Express

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

(2016) Veronica Costa et al.   Cell Reports

SPED Light Sheet Microscopy: Fast Mapping of Biological System Structure and Function

(2015) Raju Tomer et al.   CELL

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Light-sheet fluorescence microscopy for quantitative biology

(2015) Ernst H K Stelzer   NATURE METHODS

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

ScaleS: an optical clearing palette for biological imaging

(2015) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

(2014) Ki-Jun Yoon et al.   Cell Stem Cell

Light-sheet microscopy using an Airy beam

(2014) Tom Vettenburg et al.   NATURE METHODS

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis

(2012) Michael Telias et al.   DEVELOPMENTAL BIOLOGY

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light sheet microscopy of living or cleared specimens

(2011) Philipp J Keller et al.   CURRENT OPINION IN NEUROBIOLOGY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY