Article
Oncology
Yao Xu, Fanqi Shi, Yanting Zhang, Mengfan Yin, Xiuxin Han, Jinyan Feng, Guowen Wang
Summary: This study aimed to update the recent epidemiologic estimates of malignant bone tumors. The results showed differences in incidence and mortality rates across tumor types and demographic variables, providing potential suggestions for further adjustment of medical resources.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Jean-Michel Hannoun-Levi, Jocelyn Gal, Csaba Polgar, Vratislav Strnad, Kristina Loessl, Bulent Polat, Daniela Kauer-Domer, Renaud Schiappa, Crisitna Gutierrez
Summary: This study analyzed oncological prognostic factors for patients with a second ipsilateral breast tumor event (2nd IBTE) treated with second conservative treatment (2nd CT). The results showed that this treatment option had low risks of local relapse and distant metastasis within 5 years, and the GEC-ESTRO TAM score, time interval, and molecular classification were important prognostic factors.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Medicine, General & Internal
Dongrul Shin, Chang Wook Jeong, Cheryn Song, Minyong Kang, Seong Il Seo, Jung Kwon Kim, Hakmin Lee, Jinsoo Chung, Sung-Hoo Hong, Eu Chang Hwang, Cheol Kwak, Jae Young Park
Summary: A new prognostic model for clear cell metastatic renal cell carcinoma patients was developed using the KRoCS database and compared with MSKCC and IMDC models. The study identified 7 prognostic factors for poor overall survival and categorized patients into 3 risk groups with varying median survival periods. The KRoCS model outperformed other models in statistical parameters and provided valuable information for patient counseling.
Article
Urology & Nephrology
Svetlana Avulova, John C. Cheville, Christine M. Lohse, Sounak Gupta, Theodora A. Potretzke, Matvey Tsivian, R. Houston Thompson, Stephen A. Boorjian, Bradley C. Leibovich, Aaron M. Potretzke
Summary: This study validated a grading scheme for chromophobe renal cell carcinoma (ChRCC) and proposed a new four-tiered system by including tumor necrosis, which significantly improved the delineation of patient outcomes. The inclusion of tumor necrosis in the grading system helped differentiate patients with worse cancer-specific survival (CSS), leading to enhanced patient counseling post-surgery.
Article
Surgery
Irma C. C. Noordzij, Marije L. L. Hazen, Grard A. P. Nieuwenhuijzen, Rob H. A. Verhoeven, Erik J. J. Schoon
Summary: The proportion of patients receiving endoscopic treatment for early oesophageal and gastro-oesophageal junction cancer in the Netherlands increased over time, while the proportion receiving surgery decreased. The 5-year relative survival after endoscopic treatment was high and comparable to surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Teak Jun Shin, Cheryn Song, Chang Wook Jeong, Cheol Kwak, Seongil Seo, Minyong Kang, Jinsoo Chung, Sung-Hoo Hong, Eu Chang Hwang, Jae Young Park, Hakmin Lee
Summary: Metastatic renal cell carcinoma to the pancreas (PM-RCC) is infrequent in Korean patients, and compared to other mRCC, PM-RCC demonstrates a favorable prognosis. Pancreas metastasectomy is associated with prolonged survival, especially in metachronous PM-RCC.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Hisaki Aiba, Costantino Errani, Giovanni Ciani, Marco Gambarotti, Alberto Righi, Margherita Maioli, Paolo Spinnato, Giorgio Frega, Toni Ibrahim, Alessandra Longhi
Summary: This study evaluated the role of surgical margins, radiotherapy, and chemotherapy in myoepithelial carcinoma of soft tissue and bone. The results showed a high incidence of local recurrences and metastases in MC-SB, with poor prognosis for patients with metastatic disease.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Adam Kowalewski, Damian Jaworski, Jedrzej Borowczak, Mateusz Maniewski, Krzysztof Szczerbowski, Paulina Antosik, Justyna Durslewicz, Marta Smolinska, Joanna Ligmanowska, Dariusz Grzanka, Lukasz Szylberg
Summary: Resistance to systemic therapy is a major challenge in the treatment of renal cell carcinoma (RCC). This study explores the connection between TOLLIP expression, tumor characteristics, patient survival, and resistance to therapy in RCC. The findings suggest that TOLLIP may play a role in autophagy-related signaling and contribute to the development of chemoresistance in RCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Urgena Maharjan, Joonas H. Kauppila
Summary: This study evaluated the survival trends of gastric cancer in Finland from 1987-2016 and found that the 5-year survival is declining in non-cardia adenocarcinoma but improving in all gastric cancers.
Article
Oncology
Jose F. Carrillo, Jesus Manuel Flores, Gilberto Espinoza, Rafael Vazquez-Romo, Margarita C. Ramirez-Ortega, Liliana C. Carrillo, Beatriz Y. Cortes-Garcia, Francisco J. Ochoa-Carrillo, Luis F. Onate-Ocana
Summary: In patients with unresectable DTC, upfront EBRT followed by salvage surgery improves PFS and OS prognosis. High-risk histopathology and EBRT dose are independent factors affecting patient PFS and OS outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Guido Scoccianti, Roberto Scanferla, Maurizio Scorianz, Filippo Frenos, Federico Sacchetti, Francesco Muratori, Domenico A. Campanacci
Summary: This study reviewed a series of patients undergoing surgical treatment for pelvic bone metastases from RCC. The results showed a high disease-specific survival rate and a low rate of local tumor progression. Intralesional procedures such as curettage, cement, and total hip arthroplasty with cage should be considered as alternatives to more demanding surgeries.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Wolfgang Schroeder, Markus P. H. Ghadimi, Hans Schloesser, Heike Loeser, Petra Schiller, Thomas Zander, Florian Gebauer, Hans Fuchs, Alexander Quaas, Christiane J. Bruns
Summary: This study analyzed the long-term survival and recurrence patterns after pathological complete response (pCR) with and without nodal metastases following multimodal treatment of esophageal cancer. Results showed that patients without nodal metastases had higher 5-year overall survival compared to patients with metastatic nodes. The presence of nodal metastases predicted both locoregional and distant recurrence. Follow-up recommendations should take into account the presence or absence of nodal metastases in patients with pCR, and caution should be exercised when considering watch-and-wait surveillance strategies for suspected clinical complete response.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Junsheng Zhang, Ciqiu Yang, Chuqian Lei, Yi Zhang, Fei Ji, Hongfei Gao, Mei Yang, Liulu Zhang, Jieqing Li, Teng Zhu, Weiping Li, Xiaosheng Zhuang, Kun Wang
Summary: This study demonstrated that early-stage MBC patients who underwent BCT had significantly improved overall survival and breast cancer-specific survival compared to those who underwent mastectomy. The improvement was consistent across almost all different T and N stages subgroups.
Article
Oncology
Linh M. Duong, Hui Cai, Martha J. Shrubsole, Christina E. Bailey, Kamran Idrees, Xiao-Ou Shu
Summary: Robotic surgery is not inferior to laparoscopic surgery in treating early-stage HCC and may be associated with improved long-term survival.
Article
Surgery
Christina Lenschow, Sina Schraegle, Stefan Kircher, Kerstin Lorenz, Andreas Machens, Henning Dralle, Philipp Riss, Christian Scheuba, Andreas Pfestroff, Christine Spitzweg, Andreas Zielke, Anna Niessen, Cornelia Dotzenrath, Burkhard Riemann, Marcus Quinkler, Christian Vorlaender, Alexandra Zahn, Friedhelm Raue, Costanza Chiapponi, Karl Alexander Iwen, Thomas Steinmueller, Matthias Kroiss, Nicolas Schlegel
Summary: This retrospective cohort study describes the clinical presentation and workup of parathyroid carcinoma (PC) and identifies prognostic parameters for recurrence-free survival. Surgical treatment methods are diverse, and complications are frequent. Risk factors for recurrence include low T status, N0 stage at initial diagnosis, and Ki-67 <10%. Extended surgery can reduce recurrence rates.
Article
Urology & Nephrology
Zhenjie Wu, Qi Chen, Hooman Djaladat, Andrea Minervini, Robert G. Uzzo, Chandru P. Sundaram, Koon H. Rha, Mark L. Gonzalgo, Reza Mehrazin, Elio Mazzone, Jamil Marcus, Alyssa Danno, James Porter, Aeen Asghar, Fady Ghali, Georgi Guruli, Antoin Douglawi, Giovanni Cacciamani, Alireza Ghoreifi, Giuseppe Simone, Vitaly Margulis, Matteo Ferro, Riccardo Tellini, Andrea Mari, Abhishek Srivastava, James Steward, Ali Al-Qathani, Ahmad Al-Mujalhem, Amit Satish Bhattu, Alexander Mottrie, Firas Abdollah, Daniel D. Eun, Ithaar Derweesh, Alessandro Veccia, Riccardo Autorino, Linhui Wang
Summary: A scoring system based on clinical variables can accurately predict renal insufficiency for cisplatin-based adjuvant chemotherapy after minimally invasive RNU, and it may serve as a tool for patient selection.
EUROPEAN UROLOGY FOCUS
(2022)
Review
Urology & Nephrology
Zhenjie Wu, Qi Chen, Le Qu, Mingmin Li, Linhui Wang, Maria C. Mir, Umberto Carbonara, Savio D. Pandolfo, Peter C. Black, Asit K. Paul, Giuseppe Di Lorenzo, Francesco Porpiglia, Andrea Mari, Andrea Necchi, Morgan Roupret, Sarah P. Psutka, Riccardo Autorino
Summary: This study comprehensively investigated the incidence and profile of adverse events associated with immune checkpoint inhibitor therapy in urologic cancer patients. The findings revealed variations in the spectrum and incidence of adverse events across different cancer types, immune checkpoint inhibitor types, clinical settings, and therapy combinations.
Article
Urology & Nephrology
Alessandro Veccia, Umberto Carbonara, Hooman Djaladat, Reza Mehazin, Daniel D. Eun, Adam C. Reese, Xiaosong Meng, Robert Uzzo, Abhishek Srivastava, James Porter, Jason M. Farrow, Marcus L. Jamil, Giuseppe Rosiello, Riccardo Tellini, Andrea Mari, Ali Al-Qathani, Koon H. Rha, Linhui Wang, Riccardo Mastroianni, Matteo Ferro, Ottavio De Cobelli, Kevin Hakimi, Fabio Crocerossa, Alireza Ghoreifi, Giovanni Cacciamani, Amit S. Bhattu, Alexandre Mottrie, Firas Abdollah, Andrea Minervini, Zhenjie Wu, Giuseppe Simone, Ithaar Derweesh, Mark L. Gonzalgo, Vitaly Margulis, Chandru P. Sundaram, Riccardo Autorino
Summary: Robotic radical nephroureterectomy (RRNU) and laparoscopic radical nephroureterectomy (LRNU) offer comparable outcomes. RRNU is associated with a higher rate of bladder cuff excision, lower overall complications, and shorter length of stay compared to LRNU. LRNU is a negative predictor for achieving tetrafecta outcome.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Cell Biology
Aimin Jiang, Yewei Bao, Anbang Wang, Wenliang Gong, Xinxin Gan, Jie Wang, Yi Bao, Zhenjie Wu, Bing Liu, Juan Lu, Linhui Wang
Summary: A prognosis predicting and drug selection model for ccRCC patients was established based on multiomics data analysis, which could accurately predict the prognosis of ccRCC patients and have implications for drug selection.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Urology & Nephrology
Davide Loizzo, Savio D. Pandolfo, Francesco Del Giudice, Clara Cerrato, Benjamin I. Chung, Zhenjie Wu, Ciro Imbimbo, Pasquale Ditonno, Ithaar Derweesh, Riccardo Autorino
Article
Urology & Nephrology
Kevin Hakimi, Umberto Carbonara, Hooman Djaladat, Reza Mehrazin, Daniel Eun, Adam Reese, Mark L. Gonzalgo, Vitaly Margulis, Robert G. Uzzo, James Porter, Chandru P. Sundaram, Firas Abdollah, Alexandre Mottrie, Riccardo Tellini, Matteo Ferro, Arman Walia, Ava Saidian, Shady Soliman, Julia Yuan, Alessandro Veccia, Alireza Ghoreifi, Giovanni Cacciamani, Amit S. Bhattu, Xiaosong Meng, Jason M. Farrow, Marcus Jamil, Andrea Minervini, Koon H. Rha, Zhenjie Wu, Giuseppe Simone, Riccardo Autorino, Ithaar H. Derweesh
Summary: This study evaluated the outcomes of lymph node dissection in patients with upper tract urothelial carcinoma, finding that the procedure did not improve overall survival but was associated with improved recurrence-free survival in patients with clinical node negative disease and when yielding a higher number of lymph nodes.
JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Umberto Carbonara, Fabio Crocerossa, Reza Mehrazin, Riccardo Campi, Michele Marchioni, Alessandro Morlacco, Vincenzo Paglairulo, Zhenjie Wu, Riccardo Autorino, Robert J. Stein, Daniel Eun, Pasquale Ditonno, Fabrizio Dal Moro
Summary: The current systematic review indicates that robot-assisted ureteral reimplantation (RAUR) offers similar surgical outcomes compared to open ureteral reimplantation (OUR), with potential advantages in terms of lower blood loss, shorter hospital stay, catheter, and stent time.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Urology & Nephrology
Alessandro Veccia, Umberto Carbonara, Ithaar Derweesh, Reza Mehrazin, James Porter, Firas Abdollah, Elio Mazzone, Chandru P. Sundaram, Mark Gonzalgo, Riccardo Mastroianni, Alireza Ghoreifi, Giovanni E. Cacciamani, Devin Patel, Jamil Marcus, Alyssa Danno, James Steward, Amit Satish Bhattu, Aeen Asghar, Adam C. Reese, Zhenjie Wu, Robert G. Uzzo, Andrea Minervini, Koon H. Rha, Matteo Ferro, Vitaly Margulis, Lance J. Hampton, Giuseppe Simone, Daniel D. Eun, Hooman Djaladat, Alexandre Mottrie, Riccardo Autorino
Summary: This article describes the surgical steps and outcomes of Xi (R) robotic RNU. The study found that this minimally invasive procedure is reproducible and safe for treating UTUC.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Andrology
Guan-Qun Ju, Zhi-Jun Wang, Jia-Zi Shi, Zong-Qin Zhang, Zhen-Jie Wu, Lei Yin, Bing Liu, Lin-Hui Wang, Dong-Liang Xu
Summary: The study compared outcomes of extraperitoneal robotic single-port radical prostatectomy and extraperitoneal robotic multiport radical prostatectomy, and found differences in operative time, estimated blood loss, and postoperative recovery between the two groups, with single-port surgery showing advantages in certain aspects and being a viable treatment option.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Article
Urology & Nephrology
Andrew B. Katims, Rollin Say, Ithaar Derweesh, Robert Uzzo, Andrea Minervini, Zhenjie Wu, Firas Abdollah, Chandru Sundaram, Matteo Ferro, Koon Rha, Alex Mottrie, Giuseppe Rosiello, Giuseppe Simone, Daniel D. Eun, Adam Reese, Laura C. Kidd, James Porter, Amit Satish Bhattu, Mark L. Gonzalgo, Vitaly Margulis, Jamil Marcus, Alyssa Danno, Margaret Meagher, Riccardo Tellini, Andrea Mari, Alessandro Veccia, Alireza Ghoreifi, Riccardo Autorino, Hooman Djaladat, Reza Mehrazin
Summary: The study analyzed 485 patients with UTUC who underwent minimally invasive RNU and found that IVR is a relatively common event after the procedure. Risk factors include hypertension, diagnostic ureteroscopic biopsy, positive surgical margins, and transurethral resection for bladder cuff management. Avoiding certain procedures and considering alternative strategies for obtaining biopsy tissue samples may help reduce the risk of IVR.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yewei Bao, Aimin Jiang, Kai Dong, Xinxin Gan, Wenliang Gong, Zhenjie Wu, Bing Liu, Yi Bao, Jie Wang, Linhui Wang
Summary: The increased expression of DDX39 in ccRCC patients predicted worse clinical prognosis, promoted ccRCC cell proliferation, migration, and invasion, and also predicted adverse efficacy of immune checkpoint therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Urology & Nephrology
Zhenjie Wu, Mingmin Li, Jianchao Wang, Alessandro Veccia, Yifan Xu, Chao Zhang, Jizhong Ren, Lei Yin, Ming Chen, Junkai Wang, Dongliang Xu, Zongqin Zhang, Bing Liu, Bo Yang, Liping Xie, Le Qu, Linhui Wang
Summary: The study demonstrated a modified retroperitoneoscopic RNU technique that is safe and reproducible, achieving complete BCE and facilitating LND. Goals in minimally invasive RNU should include achieving BCE trifecta. Prospective comparison with open surgical technique is needed.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Yicun Wang, Jinhui Wu, Hui Chen, Yang Yang, Chengwu Xiao, Xiaoming Yi, Changjie Shi, Ke Zhong, Haowei He, Yaoming Li, Zhenjie Wu, Guangxin Zhou, Qiu Rao, Xiaoxia Wang, Xiaodie Zhou, Gwen Lomberk, Bing Liu, Jianning Zhao, Jingping Ge, Wenquan Zhou, Xiaoyuan Chu, Cheng Chen, Xuhui Zhou, Linhui Wang, Kunliang Guan, Le Qu
Summary: The study identified KLF11 as a negative regulator in sarcoma cancer stem cells, forming a negative feedback loop with YAP/TEAD. Epigenetic silencing of KLF11 in CSCs leads to sustained YAP activation, which is associated with poor prognosis and chemotherapy response in sarcoma patients. Pharmacological activation of KLF11 effectively restored chemotherapy response.