NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

(2020) Willianne I.M. Vonk et al.   MOLECULAR CELL

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

(2019) Davide D’Amico et al.   MOLECULAR CELL

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

(2019) Dana Laor et al.   Nature Communications

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans

(2019) Chaolie Huang et al.   eLife

Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis

(2019) Alicia J. Kowaltowski et al.   FASEB JOURNAL

Identifying gene function and module connections by the integration of multispecies expression compendia

(2019) Hao Li et al.   GENOME RESEARCH

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

(2018) David C. Schöndorf et al.   Cell Reports

Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment

(2017) Nathan B Basisty et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

(2017) Davide D’Amico et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans

(2016) Srinivas Ayyadevara et al.   Aging-US

Signaling Networks Determining Life Span

(2016) Celine E. Riera et al.   Annual Review of Biochemistry

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken

(2015) Olivier Benveniste et al.   ACTA NEUROPATHOLOGICA

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Fluorescent dye ProteoStat to detect and discriminate intracellular amyloid-like aggregates inEscherichia coli

(2014) Susanna Navarro et al.   Biotechnology Journal

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Functional relevance of mitochondrial abnormalities in sporadic inclusion body myositis

(2014) Pushpa Raj Joshi et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

A Reliable Way to Detect Endogenous Murine β-Amyloid

(2013) Andrew F. Teich et al.   PLoS One

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

(2011) Lin Zheng et al.   Autophagy

High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain

(2011) Ajeet Rijal Upadhaya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Sporadic inclusion-body myositis: Conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-β42 oligomers and phosphorylated tau

(2011) Valerie Askanas et al.   PRESSE MEDICALE

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Muscle type-specific responses to NAD+ salvage biosynthesis promote muscle function in Caenorhabditis elegans

(2010) Tracy L. Vrablik et al.   DEVELOPMENTAL BIOLOGY

Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans

(2009) T. L. Vrablik et al.   DEVELOPMENT

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interrelation of inflammation and APP in sIBM: IL-1β induces accumulation of β-amyloid in skeletal muscle

(2008) Jens Schmidt et al.   BRAIN

Prevalence of sporadic inclusion body myositis and factors contributing to delayed diagnosis

(2008) Merrilee Needham et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Inflammatory myopathies with mitochondrial pathology and protein aggregates

(2008) Peyker Temiz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

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(2008) G Irvine et al.   MOLECULAR MEDICINE