Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

(2020) David P. Nusinow et al.   CELL

Synthetic lethality between VPS 4A and VPS 4B triggers an inflammatory response in colorectal cancer

(2020) Ewelina Szymańska et al.   EMBO Molecular Medicine

The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection

(2019) Jorge Ruben Cabrera et al.   mBio

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Synthetic lethality as an engine for cancer drug target discovery

(2019) Alan Huang et al.   NATURE REVIEWS DRUG DISCOVERY

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases

(2018) Robert Pöhler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

(2018) Srinivas R. Viswanathan et al.   NATURE GENETICS

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

(2018) Yoshinori Takahashi et al.   Nature Communications

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

(2018) John McCullough et al.   Annual Review of Cell and Developmental Biology

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

(2018) James M. McFarland et al.   Nature Communications

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

(2017) Prasenjit Dey et al.   NATURE

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

(2017) Beata E. Mierzwa et al.   NATURE CELL BIOLOGY

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cryo-EM structures of the ATP-bound Vps4E233Q hexamer and its complex with Vta1 at near-atomic resolution

(2017) Shan Sun et al.   Nature Communications

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

(2017) Brenton R Paolella et al.   eLife

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

(2017) Nicole Monroe et al.   eLife

Mechanism of Vps4 hexamer function revealed by cryo-EM

(2017) Min Su et al.   Science Advances

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

(2016) Gregory V. Kryukov et al.   SCIENCE

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors

(2016) Agnieszka Mamińska et al.   Science Signaling

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors

(2016) Agnieszka Mamińska et al.   Science Signaling

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ

(2015) Yahui Zhang et al.   MYCOPATHOLOGIA

TP53 loss creates therapeutic vulnerability in colorectal cancer

(2015) Yunhua Liu et al.   NATURE

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

(2014) Tamás Matusek et al.   NATURE

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

(2014) Sigrid B. Thoresen et al.   NATURE CELL BIOLOGY

ARID1B is a specific vulnerability in ARID1A-mutant cancers

(2014) Katherine C Helming et al.   NATURE MEDICINE

An update on PARP inhibitors—moving to the adjuvant setting

(2014) Amir Sonnenblick et al.   Nature Reviews Clinical Oncology

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

(2014) G. R. Hoffman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

(2013) Xiang Chen et al.   CANCER CELL

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Cancer Vulnerabilities Unveiled by Genomic Loss

(2012) Deepak Nijhawan et al.   CELL

Identification of an AAA ATPase VPS4B-Dependent Pathway That Modulates Epidermal Growth Factor Receptor Abundance and Signaling during Hypoxia

(2012) H. H. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Passenger deletions generate therapeutic vulnerabilities in cancer

(2012) Florian L. Muller et al.   NATURE

CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling

(2012) Z-Y Zheng et al.   ONCOGENE

C911: A Bench-Level Control for Sequence Specific siRNA Off-Target Effects

(2012) Eugen Buehler et al.   PLoS One

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

(2012) J. G. Carlton et al.   SCIENCE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

(2011) Lee Kamentsky et al.   BIOINFORMATICS

Mechanism of Inhibition of Retrovirus Release from Cells by Interferon-Induced Gene ISG15

(2011) Z. Kuang et al.   JOURNAL OF VIROLOGY

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

The Interferon-Induced Gene ISG15 Blocks Retrovirus Release from Cells Late in the Budding Process

(2010) A. Pincetic et al.   JOURNAL OF VIROLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

(2010) E. Morita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of ESCRT Machinery in EGFR Recycling

(2009) Aleksander Baldys et al.   BIOCHEMISTRY

The ESCRT machinery at a glance

(2009) T. Wollert et al.   JOURNAL OF CELL SCIENCE

Nucleotide-Dependent Conformational Changes and Assembly of the AAA ATPase SKD1/VPS4B

(2008) Michio Inoue et al.   TRAFFIC