Article
Acoustics
Fredrik Saevik, Odd Helge Gilja, Kim Nylund
Summary: This study aimed to investigate the ability of gastrointestinal ultrasound (GIUS) to distinguish between patients with active disease and those in remission in a hospital cohort with Crohn's disease (CD). The results showed that GIUS had a high sensitivity for detecting endoscopic activity and had the potential to reduce the number of routine ileocolonoscopies in CD patients.
ULTRASCHALL IN DER MEDIZIN
(2022)
Article
Gastroenterology & Hepatology
Fredrik Saevik, Ragnar Eriksen, Geir Egil Eide, Odd Helge Gilja, Kim Nylund
Summary: A simple ultrasound activity index for Crohn's disease was constructed and validated, consisting of bowel wall thickness and colour Doppler, which correlated well with endoscopic disease activity. The index showed good reproducibility and had a strong correlation with endoscopic findings in both patient cohorts.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Tomas Ripolles, Joaquin Poza, Cristina Suarez Ferrer, Maria J. Martinez-Perez, Ana Martin-Algibez, Berta de las Heras Paez
Summary: The study aimed to assess the disease activity in patients with Crohn's disease using ultrasound, color Doppler imaging, and contrast-enhanced ultrasound. A predictive ultrasound score based on wall thickness, color Doppler grade, and contrast parameters showed high accuracy in predicting active disease. Another simpler index without contrast parameters also demonstrated high accuracy in detecting disease activity.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Tomas Ripolles, Joaquin Poza, Cristina Suarez Ferrer, Maria J. Martinez-Perez, Ana Martin-Algibez, Berta de las Heras Paez
Summary: In this study, the diagnostic accuracy of ultrasound techniques in identifying disease activity in Crohn's disease patients was tested and a sonographic score was developed for detecting disease activity. The predictive ultrasound score based on wall thickness, color Doppler grade, and contrast parameters showed high accuracy in predicting active disease, with a simpler index without contrast parameters also being effective.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Gabriele Dragoni, Matteo Gottin, Tommaso Innocenti, Erica Nicola Lynch, Siro Bagnoli, Giuseppe Macri, Andrea Giovanni Bonanomi, Beatrice Orlandini, Francesca Rogai, Stefano Milani, Andrea Galli, Monica Milla, Maria Rosa Biagini
Summary: This study compared the correlation of various intestinal ultrasound scores with endoscopic activity, and found that the IBUS-SAS score had the highest correlation with endoscopy and could assist in classifying different levels of disease activity.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shi-Si Ding, Chang Liu, Yi-Feng Zhang, Li-Ping Sun, Li-Hua Xiang, Hui Liu, Yan Fang, Wei-Wei Ren, Hui Zhao, Xiao-Min Sun, Kun Zhang, Chang-Bao Zhang, Xiao-Rong Xu, Hui-Xiong Xu
Summary: This study compared the performance of contrast-enhanced ultrasound (CEUS) with computed tomography enterography (CTE) in assessing disease activity in patients with Crohn's disease (CD). The results showed that CEUS provides a radiation-free and effective way to evaluate CD activity, avoiding frequent colonoscopy examinations, improving patient tolerance, and reducing medical costs.
Article
Medicine, General & Internal
Rune Wilkens, Dong-Hua Liao, Hans Gregersen, Henning Glerup, David A. Peters, Charlotte Buchard, Anders Tottrup, Klaus Krogh
Summary: Parameters obtained from preoperative contrast-enhanced ultrasonography and dynamic contrast-enhanced MR Enterography were associated with the biomechanical properties of strictures in Crohn's disease. Pre-stenotic dilatation on ultrasound may serve as a potential biomarker for small intestinal stricture stiffness in Crohn's disease.
Article
Biology
Razvan-Cristian Statie, Sevastita Iordache, Lucian Mihai Florescu, Ioana-Andreea Gheonea, Victor-Mihai Sacerdotianu, Bogdan Silviu Ungureanu, Ion Rogoveanu, Dan-Ionut Gheonea, Tudorel Ciurea, Dan Nicolae Florescu
Summary: This study aimed to identify the role of ultrasonography, contrast-enhanced ultrasound, and magnetic resonance imaging in evaluating ileal Crohn's disease activity. The results showed that magnetic resonance imaging had a better correlation with clinical severity scores and faecal calprotectin levels. Further studies are needed to validate these results.
Article
Gastroenterology & Hepatology
Zicheng Huang, Wenjie Cheng, Kang Chao, Jian Tang, Miao Li, Qin Guo, Guangjian Liu, Xiang Gao
Summary: This study found that baseline and postinduction intestinal ultrasound findings reliably predict long-term transmural healing (TH) and mucosal healing (MH) in patients with Crohn's disease (CD) receiving infliximab.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Thomas M. Goodsall, Vipul Jairath, Brian G. Feagan, Claire E. Parker, Tran M. Nguyen, Leonardo Guizzetti, Anil K. Asthana, Jakob Begun, Britt Christensen, Antony B. Friedman, Torsten Kucharzik, Andrew Lee, Peter J. Lewindon, Christian Maaser, Kerri L. Novak, Jordi Rimola, Kirstin M. Taylor, Stuart A. Taylor, Lauren S. White, Rune Wilkens, Stephanie R. Wilson, Emily K. Wright, Robert V. Bryant, Christopher Ma
Summary: In this study, an expert panel identified appropriate component items and applications of intestinal ultrasound for Crohn's disease clinical trials, but empirical evidence and development and validation of an ultrasound disease activity index are needed.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Xia Wang, Caidie He, Nian Wu, Yingkuan Tian, Songlin An, Wei Chen, Xiang Liu, Haonan Zhang, Shimin Xiong, Yijun Liu, Quan Li, Yuanzhong Zhou, Xubo Shen
Summary: The aim of this study was to develop a visual prediction model for gestational diabetes (GD) in pregnant women and establish an effective and practical tool for clinical application. The study established demographic-lifestyle factor models (DLFM) and demographic-lifestyle-environmental pollution factor models (DLEFM) to predict the occurrence of GD.
DIABETES OBESITY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Michael T. Dolinger, Jungwhan J. Choi, Becky L. Phan, Henrietta K. Rosenberg, John Rowland, Marla C. Dubinsky
Summary: This study aimed to explore the utility of small bowel ultrasound as a noninvasive tool to assess induction response to infliximab in pediatric Crohn's disease. The results suggest that SBUS is feasible for measuring early treatment response to IFX, with bowel wall hyperemia being the first parameter to change. Larger longitudinal studies are needed to validate the utility of SBUS as part of a disease monitoring strategy.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Immunology
Manrong He, Chao Li, Wanxin Tang, Yingxi Kang, Yongdi Zuo, Yufang Wang
Summary: This study developed a gene expression prediction model for UST response in patients with CD by analyzing transcription profiles, identifying 122 DEGs, and constructing a model with 4 genes. The results indicated significantly enriched immune response pathways in CD patients.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Gastroenterology & Hepatology
Yu-Jun Chen, Bai-Li Chen, Mei-Juan Liang, Shu-Ling Chen, Xue-Hua Li, Yun Qiu, Lan-Lan Pang, Qing-Qing Xia, Yao He, Zhi-Rong Zeng, Min-Hu Chen, Ren Mao, Xiao-Yan Xie
Summary: This pilot study suggests that changes in bowel ultrasound behavior can be assessed as early as 2 weeks after starting anti-tumor necrosis factor therapy in patients with Crohn's disease. Bowel ultrasound, along with elasticity imaging, could predict early response to anti-TNF therapy.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Lucrezia Laterza, Luca Boldrini, Huong Elena Tran, Claudio Votta, Luigi Larosa, Laura Maria Minordi, Rossella Maresca, Daniela Pugliese, Maria Assunta Zocco, Maria Elena Ainora, Loris Riccardo Lopetuso, Alfredo Papa, Alessandro Armuzzi, Antonio Gasbarrini, Franco Scaldaferri
Summary: This pilot study aimed to evaluate the use of radiomics in predicting 10-year surgery for Crohn's disease patients. A cohort of patients with CT scan enterographies and a 10-year follow-up was selected. Radiomic features were extracted and a logistic regression model was developed, achieving a successful prediction of 10-year surgery. Radiomics could serve as a helpful tool in identifying patients at high risk for surgery and requiring stricter monitoring.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Immunology
Yiding Chen, Jingxi Mu, Min Zhu, Arjudeb Mukherjee, Hu Zhang
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Gastroenterology & Hepatology
Chunxiang Ma, Yingzi Cong, Hu Zhang
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Chemistry, Analytical
Jianyu Hu, Ziyan Li, Hu Zhang, Rui Liu, Yi Lv
ANALYTICAL CHEMISTRY
(2020)
Review
Gastroenterology & Hepatology
Zhen Zeng, Arjudeb Mukherjee, Adwin Pidiyath Varghese, Xiao-Li Yang, Sha Chen, Hu Zhang
WORLD JOURNAL OF GASTROENTEROLOGY
(2020)
Review
Medicine, General & Internal
Mingshan Jiang, Jingxi Mu, Silan Shen, Hu Zhang
Summary: The outbreak of COVID-19 has led to a global public health and economic crisis, with hypercoagulability and thrombotic complications significantly influencing the prognosis of patients. This review focuses on the clinical findings, potential pathogenesis, and therapeutic strategies for hypercoagulability and thromboembolism in COVID-19 patients, especially those with preexisting digestive hypercoagulability disease.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Kexin Chen, Zhen Zeng, Chunxiang Ma, Yuan Dang, Hu Zhang
Summary: Colorectal adenocarcinoma (COAD) is a subtype of colorectal carcinoma (CRC) with development associated with genetics, immune response, and environmental factors. The study revealed a beneficial effect of Th17 cells in COAD prognosis and identified six hub genes correlated with Th17 cells and COAD prognosis, suggesting potential therapy strategies and predictive biomarkers. These findings pave the way for further exploration of the molecular mechanism of COAD.
BIOSCIENCE REPORTS
(2021)
Review
Cell Biology
Zhen Zeng, Chunxiang Ma, Kexin Chen, Mingshan Jiang, Reshma Vasu, Rui Liu, Yinglan Zhao, Hu Zhang
Summary: Gastrointestinal cancers are common and devastating worldwide, with high mortality rates despite significant treatment advances. GPCRs play crucial roles in the development of GI cancers, driving further research into new therapeutic targets.
Article
Immunology
Mingshan Jiang, Zhen Zeng, Kexin Chen, Yuan Dang, Lili Li, Chunxiang Ma, Rui Cheng, Kehan Hu, Xi Li, Hu Zhang
Summary: This study aimed to explore the diagnostic values of enterogeneous microbiotic markers in patients with Crohn's disease (CD), CD concomitant with intestinal tuberculosis (CD-ITB), and intestinal tuberculosis (ITB). The results showed that these markers could accurately differentiate CD patients from healthy controls and had different diagnostic and classification values. Additionally, the levels of these markers were associated with disease severity and the risk of related surgery.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Chunxiang Ma, Weiguo Dong, Bo Shen, Hu Zhang
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kexin Chen, Silan Shen, Yiding Chen, Mingshan Jiang, Kehan Hu, Yuheng Zou, Lili Li, Zhen Zeng, Chunxiang Ma, Yuan Dang, Hu Zhang
Summary: An inappropriate diet, such as consuming spicy food containing capsaicin, can increase the risk and worsen symptoms of inflammatory bowel disease (IBD). Capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration. Proteomic and transcriptomic analyses provide insights into the potential signaling pathway and effects of capsaicin on IBD relapse and neutrophil activation.
Review
Biochemistry & Molecular Biology
Yuan Dang, Chunxiang Ma, Kexin Chen, Yiding Chen, Mingshan Jiang, Kehan Hu, Lili Li, Zhen Zeng, Hu Zhang
Summary: The interactions among diet, intestinal immunity, and microbiota in inflammatory bowel disease (IBD) are complex and contradictory. Increasing research has provided insights into this field. A high-fat diet (HFD) disrupts intestinal immune balance by impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota. Conversely, a rational diet is believed to maintain intestinal immunity by regulating gut microbiota. This review emphasizes the crucial contributions of an HFD to the gut immune system and microbiota.
Article
Medicine, Research & Experimental
Chunqi Liu, Liang Wang, Xiaocong Liu, Yuping Tan, Lei Tao, Yuzhou Xiao, Pengchi Deng, Huijuan Wang, Qianyi Deng, Yiyun Lin, Hui Jie, Huaqin Zhang, Jing Zhang, Yong Peng, Hu Zhang, Zongguang Zhou, Qingxiang Sun, Xiaobo Cen, Yinglan Zhao
Summary: The study revealed a novel nonmetabolic function of SHMT2 in stabilizing beta-catenin to prevent its ubiquitylation-mediated degradation, providing a potential therapeutic strategy for colorectal cancer therapy.
Article
Multidisciplinary Sciences
Yanqiong Chen, Huan Tao, Silan Shen, Zhiyong Miao, Lili Li, Yongqian Jia, Hu Zhang, Xiufeng Bai, Xinyuan Fu
Article
Medicine, Research & Experimental
Ning Wang, Yuting Fu, Hu Zhang, Huipeng Shi
PRECISION CLINICAL MEDICINE
(2020)