Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients

Structural basis for catalysis and substrate specificity of human ACAT1

(2020) Hongwu Qian et al.   NATURE

Cerebellar degeneration correlates with motor symptoms in Huntington's disease

(2019) Malvindar K. Singh-Bains et al.   ANNALS OF NEUROLOGY

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2018) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice

(2017) Mahalakshmi Shankaran et al.   NEUROBIOLOGY OF DISEASE

Myelin breakdown in human Huntington’s disease: Multi-modal evidence from diffusion MRI and quantitative magnetization transfer

(2017) José Bourbon-Teles et al.   NEUROSCIENCE

The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease

(2016) Jae Whan Keum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The effect of altered sphingolipid acyl chain length on various disease models

(2015) Woo-Jae Park et al.   BIOLOGICAL CHEMISTRY

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease

(2015) Yohei Shibuya et al.   Future Medicinal Chemistry

Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease

(2015) Sarah E. Norris et al.   NEUROBIOLOGY OF AGING

Evidence for altered cholesterol metabolism in Huntington's diseasepost mortembrain tissue

(2015) Fabian Kreilaus et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation

(2015) Jeffrey B. Carroll et al.   PLoS One

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner

(2013) Kathleen A. Burke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids

(2013) Sarah K. Abbott et al.   LIPIDS

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

(2013) Valerio Leoni et al.   NEUROBIOLOGY OF DISEASE

Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

(2011) Elisa Fossale et al.   HUMAN MOLECULAR GENETICS

Increased expression of acyl-coenzyme A: cholesterol acyltransferase-1 and elevated cholesteryl esters in the hippocampus after excitotoxic injury

(2011) J.-H. Kim et al.   NEUROSCIENCE

Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease

(2011) Giuseppe Astarita et al.   PLoS One

Chain length-specific properties of ceramides

(2011) Sabine Grösch et al.   PROGRESS IN LIPID RESEARCH

Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington’s disease

(2010) Christine A. Denny et al.   JOURNAL OF NEUROCHEMISTRY

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sterols and sphingolipids: Dynamic duo or partners in crime?

(2010) Sonia Gulati et al.   PROGRESS IN LIPID RESEARCH

Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function

(2009) Jacques Fantini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids?

(2009) Lynette Hui-Wen Lee et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Altered cholesterol and fatty acid metabolism in Huntington disease

(2009) Robert C. Block et al.   Journal of Clinical Lipidology

Cholesterol involvement in the pathogenesis of neurodegenerative diseases

(2009) Jun-Ping Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease

(2008) Valerio Leoni et al.   BRAIN

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH

Low plasma total cholesterol in patients with Huntington’s disease and first-degree relatives

(2007) Manolis Markianos et al.   MOLECULAR GENETICS AND METABOLISM