Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

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High-dose rifampicin in tuberculosis: Experiences from a Dutch tuberculosis centre

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Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis

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1,4-Benzoquinone antimicrobial agents againstStaphylococcus aureusandMycobacterium tuberculosisderived from scorpion venom

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691. Activity of TNP-2092 Against Biofilms Formed by Prosthetic Joint Infection-Associated Staphylococci

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Evaluation of a Dual-Acting Antibacterial Agent, TNP-2092, on Gut Microbiota and Potential Application in the Treatment of Gastrointestinal and Liver Disorders

(2019) Ying Yuan et al.   ACS Infectious Diseases

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

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Improving treatment outcome assessment in a mouse tuberculosis model

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Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition

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Rifamycin action on RNA polymerase in antibiotic-tolerantMycobacterium tuberculosisresults in differentially detectable populations

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Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections

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Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy

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The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

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In Vitro Activity of Rifampicin and Verapamil Combination in Multidrug-Resistant Mycobacterium tuberculosis

(2015) Fernanda de Oliveira Demitto et al.   PLoS One

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

(2014) Richard E Lee et al.   NATURE MEDICINE

Optimization of the Rifampin Dosage to Improve the Therapeutic Efficacy in Tuberculosis Treatment Using a Murine Model

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Advances in the development of new tuberculosis drugs and treatment regimens

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Clofazimine: current status and future prospects

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