High-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction in Mycobacterium tuberculosis
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Title
High-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction in Mycobacterium tuberculosis
Authors
Keywords
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Journal
Scientific Reports
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-12-04
DOI
10.1038/s41598-020-78269-3
References
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Related references
Note: Only part of the references are listed.- CarD contributes to diverse gene expression outcomes throughout the genome of Mycobacterium tuberculosis
- (2019) Dennis X. Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β′ Subunit
- (2018) Maxwell A. Stefan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Host-targeted therapy for tuberculosis: Time to revisit the concept
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- Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3)
- (2018) Wei Lin et al. MOLECULAR CELL
- Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts
- (2018) Hande Boyaci et al. eLife
- Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA
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- Bacterial Transcription as a Target for Antibacterial Drug Development
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- CarD stabilizes mycobacterial open complexes via a two-tiered kinetic mechanism
- (2015) Jayan Rammohan et al. NUCLEIC ACIDS RESEARCH
- CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex
- (2015) Brian Bae et al. eLife
- CarD integrates three functional modules to promote efficient transcription, antibiotic tolerance, and pathogenesis in mycobacteria
- (2014) Ashley L. Garner et al. MOLECULAR MICROBIOLOGY
- Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD
- (2014) Elizabeth Davis et al. NUCLEIC ACIDS RESEARCH
- Structure and function of CarD, an essential mycobacterial transcription factor
- (2013) D. B. Srivastava et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the Mtb CarD/RNAP β-Lobes Complex Reveals the Molecular Basis of Interaction and Presents a Distinct DNA-Binding Domain for Mtb CarD
- (2013) Gulcin Gulten et al. STRUCTURE
- Novel Rapidly Diversifiable Antimicrobial RNA Polymerase Switch Region Inhibitors with Confirmed Mode of Action in Haemophilus influenzae
- (2012) E. T. Buurman et al. JOURNAL OF BACTERIOLOGY
- Interaction of CarD with RNA Polymerase Mediates Mycobacterium tuberculosis Viability, Rifampin Resistance, and Pathogenesis
- (2012) L. A. Weiss et al. JOURNAL OF BACTERIOLOGY
- CarD Is an Essential Regulator of rRNA Transcription Required for Mycobacterium tuberculosis Persistence
- (2009) Christina L. Stallings et al. CELL
- Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease
- (2009) Ajit Jadhav et al. JOURNAL OF MEDICINAL CHEMISTRY
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