Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1

New Insights About Doxorubicin-Induced Toxicity to Cardiomyoblast-Derived H9C2 Cells and Dexrazoxane Cytoprotective Effect: Contribution of In Vitro1H-NMR Metabonomics

(2020) Matthieu Dallons et al.   Frontiers in Pharmacology

Effects of steroidal saponins extract from Ophiopogon japonicus root ameliorates doxorubicin-induced chronic heart failure by inhibiting oxidative stress and inflammatory response

(2019) Zhongwei Wu et al.   PHARMACEUTICAL BIOLOGY

Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

(2019) Sara Emad El-Agamy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

(2019) Chien-Hsiang Hsu et al.   CELL

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

(2019) Rohan Samarakoon et al.   Biomolecules

From trends to transformation: where cardio-oncology is to make a difference

(2019) Joerg Herrmann   EUROPEAN HEART JOURNAL

Polyphenols, autophagy and doxorubicin-induced cardiotoxicity

(2017) S. Shabalala et al.   LIFE SCIENCES

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

(2017) Navid Koleini et al.   Oncotarget

Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes

(2016) Mi-Hua Liu et al.   Experimental and Therapeutic Medicine

A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence

(2016) Asish K. Ghosh et al.   Oncotarget

Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes

(2016) Paola Altieri et al.   Journal of the American Heart Association

SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways

(2015) Yang Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation

(2015) Mehtap Kilic Eren et al.   PLoS One

An overview of doxorubicin formulations in cancer therapy

(2015) Sangeeta Rivankar   Journal of Cancer Research and Therapeutics

SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis

(2014) Dana E. Martinez et al.   JOURNAL OF EXPERIMENTAL BOTANY

PDE4 in the human heart - major player or little helper?

(2013) Thomas Eschenhagen   BRITISH JOURNAL OF PHARMACOLOGY

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning

(2013) Ahmed E Enayetallah et al.   BMC Pharmacology & Toxicology

Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias

(2012) Cristina E. Molina et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

(2011) Thérèse Keravis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Obesity Induces Signs of Premature Cardiac Aging in Younger Patients

(2011) Bernd Niemann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

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(2011) Wei Xin et al.   MOLECULAR MEDICINE

New therapeutic options in the management of COPD – focus on roflumilast

(2011) Sabina Antoniu   International Journal of Chronic Obstructive Pulmonary Disease

Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices

(2010) Andrea Wohlsen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage

(2008) Yasuhiro Maejima et al.   AGING CELL

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways

(2008) Hyun-Jeong Kwak et al.   CELLULAR SIGNALLING