Article
Microbiology
Lucie Paloque, Romain Coppee, Barbara H. Stokes, Nina F. Gnadig, Karamoko Niare, Jean-Michel Augereau, David A. Fidock, Jerome Clain, Francoise Benoit-Vical
Summary: This study demonstrates that the propeller domain is not the sole mediator of PfK13-mediated artemisinin resistance, highlighting the importance of monitoring for mutations throughout PfK13. The P413A mutation in the BTB/POZ domain upstream of the propeller domain is sufficient to confer in vitro artemisinin resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Chaoguang Ji, Wenbo Yang, Yongan Wang, Chunlin Su, Xiaorui Li, Peiyuan Liu, Hanchi Yan
Summary: This paper mainly studied the oligomerization of NPR1, a SA receptor in plants, and found that the residue His80 plays a key role in this process. The findings help us understand the conformational conversion mechanism of NPR1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mengwei Zhao, Yu Ge, Zhangyan Xu, Xue Ouyang, Yuling Jia, Jiangtao Liu, Meixiang Zhang, Yuyan An
Summary: This study identifies a negative regulator, NbBTB, which negatively modulates both plant basal defense and effector-triggered immunity (ETI) in response to the oomycete pathogen Phytophthora parasitica. It is specifically involved in the defense against oomycete pathogen and does not affect resistance to bacterial pathogens. NbBTB negatively regulates the hypersensitive response triggered by avirulence proteins and affects effector protein accumulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Oncology
Haorui Zhang, Chenxi Ouyang
Summary: Breast cancer is the leading cause of death for women in China and abroad, with a significant impact on their quality of life. The BTB protein family, initially discovered in drosophila, has been found to be involved in several critical biological functions and signaling pathways related to breast cancer. This review provides an update on potential molecular targets for treating breast cancer and offers new insights into the study of the BTB protein family. Rating: 8/10.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rosita Russo, Veronica Russo, Francesco Cecere, Mariangela Valletta, Maria Teresa Gentile, Luca Colucci-D'Amato, Claudia Angelini, Andrea Riccio, Paolo Vincenzo Pedone, Angela Chambery, Ilaria Baglivo
Summary: ZBTB2, a protein from the BTB/POZ zinc-finger family, plays a crucial role in cell proliferation, human cancers, and DNA methylation regulation. Through mass spectrometry analysis, ZBTB2 is found to interact with various components of chromatin remodeling complexes and the NuRD complex.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Zi-Xiong Li, Ze-Nan Huang, Hui Luo, Xiong-Bin Yang, Yu-Lin Wang, Jie-Xin Chen, Xiao-Kai Ma, Feng Xu, Tian-Tian Wang, Ling Lin
Summary: This study revealed an inverse association between BTBD7 and SLUG expression in HRNBC patients. Higher expression of BTBD7 was correlated with poor clinicopathologic features and prognosis in HRNBC patients. Silencing of BTBD7 inhibited EMT by regulating SLUG expression, suggesting that BTBD7 could be a potential molecular target for gene therapy in HRNBC patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Plant Sciences
Mengqi Ding, Yuqi He, Kaixuan Zhang, Jinbo Li, Yaliang Shi, Mengyu Zhao, Yu Meng, Milen I. Georgiev, Meiliang Zhou
Summary: This study reveals the mechanism of a transcription suppressor, FtERF-EAR3, in regulating flavonoid biosynthesis in Tartary buckwheat. FtERF-EAR3 inhibits FtF3H expression and flavonoid biosynthesis by binding to the GCC-box in the promoter of FtF3H. The gene expression of FtERF-EAR3 is induced by JA and the protein is degraded through the FtBPM3-dependent 26S proteasome pathway. Understanding the regulation mechanism of flavonoid biosynthesis in Tartary buckwheat is significant for improving its production efficiency.
Article
Multidisciplinary Sciences
Swarupa Nanda Mandal, Jacobo Sanchez, Rakesh Bhowmick, Oluwatobi R. Bello, Coenraad R. Van-Beek, Benildo G. de los Reyes
Summary: This study analyzed 110 BTB/POZ encoding gene loci in the genome of O. rufipogon and identified nine novel BTB/POZ genes with orthologs in other Poaceae species. The study sheds light on the evolution and functional divergence of this gene family.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Haijun Gu, Jia He, Yuzhan Li, Dazhao Mi, Tian Guan, Weikai Guo, Bo Liu, Yihua Chen
Summary: B-cell lymphoma 6 (BCL6) is a transcriptional repressor that is highly expressed in malignant cells and drives tumorigenesis. Targeting BCL6 may be a promising therapeutic strategy for treating lymphomas. This review comprehensively discusses the latest development of BCL6 inhibitors in diffuse large B-cell lymphoma, including their pharmacophores and efficacies.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Plant Sciences
Spela Tomaz, Marko Petek, Tjasa Lukan, Karmen Pogacar, Katja Stare, Erica Teixeira Prates, Daniel A. Jacobson, Jan Zrimec, Gregor Bajc, Matej Butala, Marusa Pompe Novak, Quentin Dudley, Nicola Patron, Ajda Taler-Vercic, Aleksandra Usenik, Dusan Turk, Salome Prat, Anna Coll, Kristina Gruden
Summary: This study identified a novel potato transcription factor, StTGA2.1, which plays a crucial role in hormone-mediated immune responses by interacting with other transcription factors. The study also revealed the molecular mechanisms of StTGA2.1 and its regulation of key genes involved in plant immune response.
Article
Multidisciplinary Sciences
Neil J. Ingham, Navid Banafshe, Clarisse Panganiban, Julia L. Crunden, Jing Chen, Morag A. Lewis, Karen P. Steel
Summary: Progressive low-frequency recessive hearing impairment was observed in mutant mouse lines carrying different mutant alleles of the Klhl18 gene, with ABR thresholds increasing progressively from 4 weeks old onwards, while DPOAE sensitivity and amplitudes remained normal.
Article
Multidisciplinary Sciences
Neil L. Ingham, Navid Banafshe, Clarisse A. Panganiban, Julia P. Crunden, Jing Chen, Morag Lewis, Karen Steel
Summary: Mutations in the Klhl18 gene result in progressive low-frequency hearing impairment in mice, affecting inner hair cell stereocilia while cochlear outer hair cell function remains normal. This indicates the importance of Klhl18 in maintaining inner hair cell function at low frequencies.
Article
Immunology
Yayi Gao, Monica Zamisch, Melanie Vacchio, Laura Chopp, Thomas Ciucci, Elliott L. Paine, Gaelyn C. Lyons, Jia Nie, Qi Xiao, Ekaterina Zvezdova, Paul E. Love, Charles R. Vinson, Lisa M. Jenkins, Remy Bosselut
Summary: The NuRD complex is identified as a critical cofactor for Thpok, a BTB-ZF transcription factor that controls T cell development. NuRD is involved in the repression of CD8(+) lineage genes by Thpok, but is dispensable for Cd4 expression. This study reveals the importance of cofactor binding in the functional specificity of BTB-ZF factors.
SCIENCE IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Wenjing Hu, Hongjun Fang, Yu Peng, Li Li, Shulei Liu, Hongmei Liao, Jingwen Tang, Jurong Yi, Qingqing Liu, Li Xu, Liwen Wu
Summary: This study reported a case of neurodevelopmental disorder in a child, possibly the first Asian NSDVS case report. Genetic testing can provide more accurate diagnoses for children with NDD showing low phenotypic specificity, aiding in the formulation of rehabilitation training plans and genetic counseling for patients' families.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chaomei Xiang, Karla K. Frietze, Yingtao Bi, Yanwen Li, Valentina Dal Pozzo, Sharmistha Pal, Noah Alexander, Valerie Baubet, Victoria D'Acunto, Christopher E. Mason, Ramana Davuluri, Nadia Dahmane
Summary: RP58 plays a crucial role in neuronal differentiation in the mouse brain and is involved in regulating transcriptional programs in embryonic neocortical neurons, including the repression of genes associated with glioma progression and pluripotency. Reintroducing RP58 into glioma stem cells not only promotes aspects of neuronal differentiation, but also decreases stem cell characteristics, suggesting that RP58 may be a key factor in preventing brain diseases such as glioma progression.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
