Article
Pharmacology & Pharmacy
Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung
Summary: This study compared the pharmacokinetic profiles of a fixed-dose combination of amlodipine, losartan, and chlorthalidone with the separate components. The results showed that the fixed-dose combination was equivalent to individual tablets in terms of pharmacokinetics and tolerability.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Shuyang Zhang, Ying Li, Xin Xu, Rui Xu, Linchao Zhang, Xiaoqun Wan, Zhuhua Yao, Yuemin Sun, Yong Liu, Jianping Bin, Zhen Wang, Shuren Li, Ping Yang, Xiping Xu, Weidong Liang, Xiaohong Gao, Xiaodong Li, Min Jia, Guang Ma, Xiang Gu, Chang Hong
Summary: This study compared the efficacy and safety of single-pill amlodipine besylate/losartan (AML/LOS) and losartan alone in Chinese patients with inadequately controlled hypertension after losartan treatment. The results showed that AML/LOS was more effective in reducing blood pressure compared to losartan alone, and both treatments were safe and well tolerated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Ki-Chul Sung, Jung Hoon Sung, Eun Joo Cho, Jeong Cheon Ahn, Seung Hwan Han, Weon Kim, Kye Hun Kim, Il Suk Sohn, Jinho Shin, Seok Yeon Kim, Kwang-il Kim, Seok Min Kang, Sung-Ji Park, Yong-Jin Kim, Joon-Han Shin, Seong-Mi Park, Chang-Gyu Park
Summary: This clinical trial assessed the efficacy and safety of low-dose triple combinations of amlodipine, telmisartan, and chlorthalidone in patients with essential hypertension. The results showed that this combination treatment effectively lowered blood pressure in patients over an 8-week period without any safety concerns.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Jieun Lee, Jaeyun Choi, Yunjin Yum, Hyung Joon Joo, Yong-Hyun Kim, Hyonggin An, Eung Ju Kim
Summary: This study evaluated the real-world clinical efficacy and safety of amlodipine/losartan-based single-pill combinations (SPCs) for hypertension in patients in Korea. Target blood pressure achievement rates were high across the three amlodipine/losartan-based SPC groups, with the ALR combination showing better target LDL-C goal achievement. Safety endpoints were generally similar among the groups, with lower incidence rates of hyperuricemia in the AL and ALR groups compared to the ALC group. All SPCs demonstrated excellent drug adherence.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Medicine, General & Internal
Rajiv Agarwal, Arjun D. Sinha, Andrew E. Cramer, Mary Balmes-Fenwick, Jazmyn H. Dickinson, Fangqian Ouyang, Wanzhu Tu
Summary: In patients with CKD and poorly controlled hypertension, chlorthalidone therapy improved blood pressure control at 12 weeks compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Areef Ishani, William C. Cushman, Sarah M. Leatherman, Robert A. Lew, Patricia Woods, Peter A. Glassman, Addison A. Taylor, Cynthia Hau, Alison Klint, Grant D. Huang, Mary T. Brophy, Louis D. Fiore, Ryan E. Ferguson
Summary: A study found that there was little difference in the prevention of major adverse cardiovascular events between chlorthalidone and hydrochlorothiazide in elderly patients with hypertension.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Peripheral Vascular Disease
Eun Joo Cho, Moo Hyun Kim, Young-Hak Kim, Kiyuk Chang, Dong-Ju Choi, Woong Chol Kang, Jinho Shin, Seong Hwan Kim, Namho Lee, Jang Won Son, Joon-Hyung Doh, Woo-Shik Kim, Soon Jun Hong, Moo-Yong Rhee, Youngkeun Ahn, Sang-Wook Lim, Seung Pyo Hong, So-Yeon Choi, Min Su Hyon, Jin-Yong Hwang, Kihwan Kwon, Kwang Soo Cha, Sang-Hyun Ihm, Jae-Hwan Lee, Byung-Su Yoo, Hyo-Soo Kim
Summary: The authors evaluated the efficacy, safety, and characteristics of hypertensive patients who responded well to standard dose triple combination therapy. The study showed that the triple therapy was effective and safe in controlling blood pressure, with higher achievement rates in female and older patients.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Editorial Material
Nursing
Irina Benenson
Summary: Low-dose combination therapy is a safe and effective option for managing hypertension. It reduces pill burden and improves blood pressure control. Nurse practitioners should take into account various factors when considering this approach for different patient groups.
JNP- THE JOURNAL FOR NURSE PRACTITIONERS
(2023)
Article
Peripheral Vascular Disease
Deep Vakil, Stavros Zinonos, John B. Kostis, Jeanne M. Dobrzynski, Nora M. Cosgrove, Abel E. Moreyra, William J. Kostis
Summary: This post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) showed that chlorthalidone had higher monotherapy failure rates compared to amlodipine in the standard treatment group, likely due to decisions made by the investigative teams.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Medicine, General & Internal
Caroline Foch, Jan Feifel, Ulrike Gottwald-Hostalek
Summary: This study compared the effects of a low-dose combination of amlodipine and bisoprolol with up titration to maximum dose of amlodipine on blood pressure in hypertensive patients. The findings showed a greater decrease in diastolic blood pressure with the low-dose combination therapy.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Review
Medicine, General & Internal
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: Although various guidelines for cardiovascular disease prevention have been established, the optimal drug therapy is often not implemented due to poor medication adherence and clinical inertia. Polypill strategies, which include combination tablets of three or more medications, have been proven to be useful in preventing cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Peripheral Vascular Disease
Michael E. Ernst, Michelle A. Fravel
Summary: Thiazide-type diuretics exert their primary action in the distal tubule and have been widely used in the management of hypertension for over 60 years. They are reliably effective as monotherapy and can augment the efficacy of other antihypertensive drugs when used in combination. Thiazides are recommended as first-line agents in major domestic and international guidelines due to their ability to lower cardiovascular events.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Jaejin An, Tiffany Luong, Lei Qian, Rong Wei, Ran Liu, Paul Muntner, Jeffrey Brettler, Marc G. Jaffe, Andrew E. Moran, Kristi Reynolds
Summary: The study found that patients who initiated ACEI-thiazide diuretic combination therapy were more likely to achieve BP goals compared with those who initiated monotherapy.
Review
Food Science & Technology
Sahar Golpour-Hamedani, Amir Hadi, Delaram SafariMalekabadi, Ameneh Najafgholizadeh, Gholamreza Askari, Makan Pourmasoumi
Summary: This study found that nigella supplementation can significantly reduce blood pressure, with the best effect observed with a daily dose of 2000 mg and 8 weeks of supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Hong-Qi Li, Xun Wang, Hui-Fu Wang, Wei Zhang, Jing-Hui Song, Song Chi, Yan-Ping Sun, Xiao-Ling Zhong, Teng Ma, Guo-Zheng Dai, Lan Tan, Qiang Dong, Jin-Tai Yu
Summary: The study found that for every 10 mmHg increase in blood pressure, the odds of ICAS increased by 32%, 28%, and 35% respectively; an increase in systolic blood pressure and pulse pressure were also associated with higher risk of ICAS burden.
Article
Clinical Neurology
Hyo Suk Nam, Young Dae Kim, Jin Kyo Choi, Minyoul Baik, Byung Moon Kim, Dong Joon Kim, JoonNyung Heo, Dong Hoon Shin, Kyung-Yul Lee, Yo Han Jung, Jang-Hyun Baek, Yang-Ha Hwang, Sung-Il Sohn, Jeong-Ho Hong, Hyungjong Park, Chi Kyung Kim, Gyu Sik Kim, Kwon-Duk Seo, Kijeong Lee, Jung Hwa Seo, Oh Young Bang, Woo-Keun Seo, Jong-Won Chung, Jun Young Chang, Sun U. Kwon, Jun Lee, Jinkwon Kim, Joonsang Yoo, Tae-Jin Song, Seong Hwan Ahn, Bang-Hoon Cho, Han-Jin Cho, Jae Guk Kim, Yoonkyung Chang, Chan Joo Lee, Sungha Park, Goeun Park, Hye S. Lee
Summary: The study aims to investigate the impact of blood pressure management on the prognosis of stroke patients after successful recanalization following intra-arterial treatment, with the results providing evidence for the effectiveness of active blood pressure control.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Peripheral Vascular Disease
Kyeong-Hyeon Chun, Jung Mi Park, Chan Joo Lee, Jaewon Oh, Sungha Park, Seok-Min Kang, Sang-Hak Lee
Summary: Statin use was not associated with cardiovascular risk reduction in high-risk individuals with normal or near normal coronary arteries.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Urology & Nephrology
Jong Hyun Jhee, Donghwan Oh, Jiwon Seo, Chan Joo Lee, Min-Yu Chung, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Sungha Park, Tae-Hyun Yoo
Summary: This study evaluated the association between short-term blood pressure variability and kidney disease outcomes in hypertensive patients. The results showed that short-term blood pressure variability is associated with the development of kidney disease outcome in hypertensive patients, independent of 24-hour blood pressure levels.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Genetics & Heredity
Hongkyung Kim, Yeeun Shim, Taek Gyu Lee, Dongju Won, Jong Rak Choi, Saeam Shin, Seung-Tae Lee
Summary: This study introduces a visualization tool called CABANA that allows users to intuitively identify CNVs in NGS data. Through its application in patients with neuromuscular disorders, CABANA's diagnostic yield was deemed acceptable, making it expected to help researchers accurately identify CNVs and reduce the need for subsequent confirmation testing.
Article
Peripheral Vascular Disease
Tae-Hyun Yoo, Soon Jun Hong, Sunggyun Kim, Seokjoon Shin, Dong Ki Kim, Jung Pyo Lee, Sang Youb Han, Sangho Lee, Jong Chul Won, Young Sun Kang, Jongha Park, Byoung-Geun Han, Ki-Ryang Na, Kyu Yeon Hur, Yong-Jin Kim, Sungha Park
Summary: This study compares the antiproteinuric effects of fimasartan and losartan in patients with diabetic kidney disease. The results show that fimasartan significantly reduces albuminuria compared to losartan, even after adjusting for systolic blood pressure levels. There were no significant differences in adverse events between the two drugs.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Kazuomi Kario, Ji-Guang Wang, Yook-Chin Chia, Tzung-Dau Wang, Yan Li, Saulat Siddique, Jinho Shin, Yuda Turana, Peera Buranakitjaroen, Chen-Huan Chen, Hao-Min Cheng, Minh Van Huynh, Jennifer Nailes, Apichard Sukonthasarn, Yuqing Zhang, Jorge Sison, Arieska Ann Soenarta, Sungha Park, Guru Prasad Sogunuru, Jam Chin Tay, Boon Wee Teo, Kelvin Tsoi, Narsingh Verma, Satoshi Hoshide
Summary: Morning hypertension is an important clinical target for blood pressure control, with two types: morning surge type and sustained hypertension type. Both increase the risk of cardiovascular and renal diseases. Asians are more susceptible to morning hypertension, making its management especially important in Asia.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Medicine, General & Internal
Rachel Marjorie Wei Wen Tseng, Tyler Hyungtaek Rim, Eduard Shantsila, Joseph K. Yi, Sungha Park, Sung Soo Kim, Chan Joo Lee, Sahil Thakur, Simon Nusinovici, Qingsheng Peng, Hyeonmin Kim, Geunyoung Lee, Marco Yu, Yih-Chung Tham, Ameet Bakhai, Paul Leeson, Gregory Y. H. Lip, Tien Yin Wong, Ching-Yu Cheng
Summary: This study aims to validate a novel cardiovascular disease risk stratification system (Reti-CVD) based on retinal photographs. The results show that Reti-CVD accurately predicts cardiovascular events and helps discern the borderline risk group. This study is of great significance for early intervention in cardiovascular disease.
Article
Medical Laboratory Technology
Yangsoon Lee, Hye Gyung Bae, Dongju Won, Woobin Yun, Hyukmin Lee, Jong Rak Choi, Young Uh, Kyungwon Lee
Summary: In this study, the distribution of GBS isolates in pregnant Korean women was investigated. CC1 was the dominant lineage, followed by CC19, CC12, and CC17. The low prevalence of CC17 GBS colonization may explain the low frequency of neonatal GBS infections. Whole-genome sequencing is a useful tool for predicting antimicrobial susceptibility and capsular serotypes in GBS isolates.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Immunology
Ki Hyun Lee, Dongju Won, Jinnam Kim, Jung Ah Lee, Chang Hyup Kim, Jung Ho Kim, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Hyunsoo Cho, Haerim Chung, June-Won Cheong, Seung-Tae Lee, Ji Eun Jang, Saeam Shin, Jin Young Ahn
Summary: Whole-genome sequencing of plasma microbial Aspergillus cell-free DNA is a useful noninvasive diagnostic approach for patients with hematologic malignancies and a high risk of invasive aspergillosis. It can accurately diagnose invasive aspergillosis in patients with hematologic malignancy or COVID-19.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Soon Sung Kwon, Youn Keong Cho, Seungmin Hahn, Jiyoung Oh, Dongju Won, Saeam Shin, Ji-Man Kang, Jong Gyun Ahn, Seung-Tae Lee, Jong Rak Choi
Summary: Inborn errors of immunity (IEI) refer to a group of genetic disorders characterized by defects in the immune system, leading to increased susceptibility to infections and complications. This study evaluated the clinical utility of clinical exome sequencing (CES) for diagnosing IEI. CES was performed on 37 Korean patients with suspected IEI symptoms, signs, or laboratory abnormalities. CES successfully diagnosed IEI in 15 out of 37 patients (40.5%), detecting several previously unreported variants. The findings highlight the diagnostic value of CES in accurate diagnosis and appropriate treatment of IEI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Sungun Bang, Dongju Won, Saeam Shin, Kang Su Cho, Jae Won Park, Jongsoo Lee, Young Deuk Choi, Suwan Kang, Seung-Tae Lee, Jong Rak Choi, Hyunho Han
Summary: In our study, we discovered genetic mutations in the DNA of cancer cells obtained from the blood of metastatic prostate cancer patients. These mutations were more common in patients with aggressive and progressing cancer that did not respond to conventional treatment. Compared to the traditional method of measuring prostate-specific antigen (PSA) levels, these genetic mutations were more sensitive in detecting prostate cancer progression. This suggests that a simple blood test could be used to track genetic mutations, identify aggressive cancer subtypes, monitor disease progression, and improve the management of advanced prostate cancer.
Review
Peripheral Vascular Disease
Sungha Park, Jinho Shin, Sang Hyun Ihm, Kwang-il Kim, Hack-Lyoung Kim, Hyeon Chang Kim, Eun Mi Lee, Jang Hoon Lee, Shin Young Ahn, Eun Joo Cho, Ju Han Kim, Hee-Taik Kang, Hae-Young Lee, Sunki Lee, Woohyeun Kim, Jong-Moo Park
Summary: The prevalence of resistant hypertension is expected to rise due to the increasing prevalence of obesity, chronic kidney disease, and diabetes, all of which are associated with resistant hypertension. Common issues in patients with apparent treatment-resistant hypertension include pseudoresistant hypertension and non-adherence. Screening for secondary causes and emphasizing drug adherence through methods such as home blood pressure monitoring are important in managing resistant hypertension.
CLINICAL HYPERTENSION
(2023)
Article
Immunology
Ga Hye Lee, Jee Youn Lee, Jiyeon Jang, Yeon Jun Kang, Seung Ah Choi, Hyeon Chang Kim, Sungha Park, Myoung Soo Kim, Won-Woo Lee
Summary: Kidney transplant (KT) is the most effective treatment for end-stage renal disease. The immunosuppressant anti-thymocyte globulin (ATG) treatment may contribute to the accumulation of senescent T cells, leading to potential long-term clinical implications for kidney transplant patients. Therefore, comprehensive and long-term immune monitoring is necessary for these patients.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Review
Peripheral Vascular Disease
Sang-Hyun Ihm, Jae-Hyeong Park, Jang Young Kim, Ju-Han Kim, Kwang-Il Kim, Eun Mi Lee, Hae-Young Lee, Sungha Park, Jinho Shin, Cheol-Ho Kim
Summary: Home blood pressure measurement (HBPM) is advantageous in diagnosing and treating various issues related to hypertension and has shown better predictive values in cardiovascular morbidity and mortality than office blood pressure monitoring.
CLINICAL HYPERTENSION
(2022)
Article
Medicine, General & Internal
Chan Joo Lee, Jung-Hoon Sung, Tae-Soo Kang, Sungha Park, Sang-Hak Lee, Jong-Youn Kim, Byeong-Kuek Kim
Summary: This study compared the effects of telmisartan and amlodipine on glucose metabolism in hypertensive atherosclerotic cardiovascular disease (ASCVD) patients with impaired fasting glucose (IFG) requiring high-intensity rosuvastatin therapy. The results showed that telmisartan did not decrease the insulin resistance, but preserved insulin secretion, leading to a regression from IFG to normal glucose levels and preventing the onset of new-onset diabetes mellitus.