Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo
Authors
Keywords
-
Journal
Frontiers in Cellular Neuroscience
Volume 14, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-12-08
DOI
10.3389/fncel.2020.594561
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Tau drives translational selectivity by interacting with ribosomal proteins
- (2019) Shon A. Koren et al. ACTA NEUROPATHOLOGICA
- Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains
- (2019) Peng Yin et al. ACTA NEUROPATHOLOGICA
- Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions
- (2019) Julia K. Nussbacher et al. NEURON
- TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1
- (2019) Jen-Fei Chu et al. Cell Reports
- TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration
- (2018) Ryo Endo et al. BIOLOGICAL PSYCHIATRY
- Pathomechanisms of TDP-43 in neurodegeneration
- (2018) Ju Gao et al. JOURNAL OF NEUROCHEMISTRY
- Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
- (2018) Yong-Jie Zhang et al. NATURE MEDICINE
- ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS
- (2018) Jone López-Erauskin et al. NEURON
- ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay
- (2018) Marisa Kamelgarn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spatially and temporally regulating translation via mRNA-binding proteins in cellular and neuronal function
- (2017) Paul G. Donlin-Asp et al. FEBS LETTERS
- Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes
- (2017) Arianna Russo et al. HUMAN MOLECULAR GENETICS
- Regulation of mRNA Translation in Neurons—A Matter of Life and Death
- (2017) Mridu Kapur et al. NEURON
- RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration
- (2017) Daisuke Ito et al. Science Translational Medicine
- Multifarious Functions of the Fragile X Mental Retardation Protein
- (2017) Jenna K. Davis et al. TRENDS IN GENETICS
- Control of mRNA Translation in ALS Proteinopathy
- (2017) Gianluca Cestra et al. Frontiers in Molecular Neuroscience
- Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis
- (2016) S. Meier et al. JOURNAL OF NEUROSCIENCE
- Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
- (2016) Sebum Lee et al. NEURON
- Analysis of translation using polysome profiling
- (2016) Héloïse Chassé et al. NUCLEIC ACIDS RESEARCH
- PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
- (2015) Helois Radford et al. ACTA NEUROPATHOLOGICA
- Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
- (2015) Adam K. Walker et al. ACTA NEUROPATHOLOGICA
- Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain
- (2015) Guohao Wang et al. Molecular Neurodegeneration
- Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
- (2015) Shuying Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
- (2015) M Halliday et al. Cell Death & Disease
- Reversible Behavioral Phenotypes in a Conditional Mouse Model of TDP-43 Proteinopathies
- (2014) J. A. Alfieri et al. JOURNAL OF NEUROSCIENCE
- Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis
- (2014) C. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation
- (2014) Denise Cook et al. Cell Reports
- ER stress-induced cell death mechanisms
- (2013) Renata Sano et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
- (2013) Hyung-Jun Kim et al. NATURE GENETICS
- Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
- (2013) J. A. Moreno et al. Science Translational Medicine
- Characterization and Analysis of the Composition and Dynamics of the Mammalian Riboproteome
- (2013) Markus Reschke et al. Cell Reports
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
- (2011) Fabienne C. Fiesel et al. NUCLEIC ACIDS RESEARCH
- Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
- (2010) Laetitia Miguel et al. NEUROBIOLOGY OF DISEASE
- Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
- (2009) Brian D. Freibaum et al. JOURNAL OF PROTEOME RESEARCH
- SUnSET, a nonradioactive method to monitor protein synthesis
- (2009) Enrico K Schmidt et al. NATURE METHODS
- Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
- (2008) Lionel M. Igaz et al. AMERICAN JOURNAL OF PATHOLOGY
- SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
- (2008) Xiaoju Max Ma et al. CELL
- Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation
- (2008) Matthew J. Winton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search