T Cells as Guardians of Pain Resolution

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury

(2020) Marcela Davoli-Ferreira et al.   PAIN

Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability

(2020) Geoffroy Laumet et al.   PAIN

Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: toxicology and pain efficacy assessments

(2020) Linda R. Watkins et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulatory T cells and their derived cytokine, interleukin-35, reduce pain in experimental autoimmune encephalomyelitis

(2019) Samuel S Duffy et al.   JOURNAL OF NEUROSCIENCE

Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice

(2019) Geoffroy Laumet et al.   PAIN

Comprehensive Phenotyping of T Cells Using Flow Cytometry

(2019) Charlotte M. Mousset et al.   CYTOMETRY PART A

Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy

(2019) Alex Molassiotis et al.   BMC CANCER

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

(2019) Zhoumou Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-specific role of HDAC6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers

(2019) Jiacheng Ma et al.   PAIN

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

(2019) Roman Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cells as an Emerging Target for Chronic Pain Therapy

(2019) Geoffroy Laumet et al.   Frontiers in Molecular Neuroscience

Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice

(2019) Lilian Basso et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management

(2019) Arden G. Vanderwall et al.   Frontiers in Immunology

Persistent Postsurgical Pain

(2018) Philippe Richebé et al.   ANESTHESIOLOGY

Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A 2A receptor agonists

(2018) Andrew J. Kwilasz et al.   BRAIN BEHAVIOR AND IMMUNITY

Experimental drugs for neuropathic pain

(2018) Kinga Salat et al.   Current Neuropharmacology

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transition to chronic pain: opportunities for novel therapeutics

(2018) Theodore J. Price et al.   NATURE REVIEWS NEUROSCIENCE

Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling

(2018) Geoffroy Laumet et al.   NEUROPSYCHOPHARMACOLOGY

Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice

(2018) Lilian Basso et al.   PAIN

Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation

(2018) Kathleen A. Sluka et al.   PAIN

Macrophage angiotensin II type 2 receptor triggers neuropathic pain

(2018) Andrew J. Shepherd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats

(2018) Andrew J. Kwilasz et al.   BRAIN BEHAVIOR AND IMMUNITY

T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice

(2017) Lilian Basso et al.   JOURNAL OF GASTROENTEROLOGY

Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis

(2017) Uta Baddack-Werncke et al.   Journal of Neuroinflammation

T-Cell Mediation of Pregnancy Analgesia Affecting Chronic Pain in Mice

(2017) Sarah F. Rosen et al.   JOURNAL OF NEUROSCIENCE

Transition from acute to chronic pain after surgery

(2017) Patricia Lavandʼhomme   PAIN

Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat

(2017) Pedro Alvarez et al.   PAIN

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

(2017) Karen Krukowski et al.   PAIN

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain

(2016) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain

(2016) K. Krukowski et al.   JOURNAL OF NEUROSCIENCE

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy

(2016) Hongmei Zhang et al.   JOURNAL OF PAIN

Re-energizing the Development of Pain Therapeutics in Light of the Opioid Epidemic

(2016) Phil Skolnick et al.   NEURON

Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice

(2016) Audrey Leung et al.   PAIN

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy

(2015) Antonio Montes et al.   ANESTHESIOLOGY

Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury

(2015) Justin G. Lees et al.   CYTOKINE

Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice

(2015) Sergio M. Borghi et al.   EXPERIMENTAL PHYSIOLOGY

Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice

(2015) R. A. Brachman et al.   JOURNAL OF NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

The therapeutic potential of interleukin-10 in neuroimmune diseases

(2015) A.J. Kwilasz et al.   NEUROPHARMACOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Monocytes/Macrophages Control Resolution of Transient Inflammatory Pain

(2014) Hanneke L.D.M. Willemen et al.   JOURNAL OF PAIN

Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

(2014) Marta Seretny et al.   PAIN

Subgrouping of Patients With Rheumatoid Arthritis Based on Pain, Fatigue, Inflammation, and Psychosocial Factors

(2014) Yvonne C. Lee et al.   Arthritis & Rheumatology

Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons

(2013) Kai-Feng Shen et al.   EXPERIMENTAL NEUROLOGY

Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice

(2013) Jérôme Boué et al.   GASTROENTEROLOGY

Constitutive  -Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence

(2013) G. Corder et al.   SCIENCE

The Management of Chronic Pain in Important Patient Subgroups

(2012) Paolo Cherubino et al.   CLINICAL DRUG INVESTIGATION

Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis

(2012) Paul J. Austin et al.   PAIN

Macrophage polarization and bacterial infections

(2011) Jean-Louis Mège et al.   CURRENT OPINION IN INFECTIOUS DISEASES

T lymphocytes containing β-endorphin ameliorate mechanical hypersensitivity following nerve injury

(2010) Dominika Labuz et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

(2010) Hanneke L.D.M. Willemen et al.   PAIN

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

Chronic post-surgical pain: 10 years on

(2008) W.A. Macrae   BRITISH JOURNAL OF ANAESTHESIA