Type VII Toxin/Antitoxin Classification System for Antitoxins that Enzymatically Neutralize Toxins

A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition

(2020) Sooyeon Song et al.   Frontiers in Microbiology

A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems

(2020) Yiming Cai et al.   Science Advances

Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism

(2020) Xia Yu et al.   Communications Biology

Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system

(2020) Jianyun Yao et al.   NUCLEIC ACIDS RESEARCH

Mechanism of regulation and neutralization of the AtaR–AtaT toxin–antitoxin system

(2019) Dukas Jurėnas et al.   Nature Chemical Biology

Toxin–antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA–KacT complex

(2019) Hongliang Qian et al.   NUCLEIC ACIDS RESEARCH

Structure–function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN–MNT toxin–antitoxin system

(2018) Xuanyan Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-segregational Killing and Phage Inhibition Are Not Mediated by Cell Death Through Toxin/Antitoxin Systems

(2018) Sooyeon Song et al.   Frontiers in Microbiology

AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet

(2017) Dukas Jurėnas et al.   Nature Chemical Biology

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

An oxygen-sensitive toxin–antitoxin system

(2016) Oriol Marimon et al.   Nature Communications

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

(2015) Alexander Harms et al.   Cell Reports

Identification and characterization of a HEPN-MNT family type II toxin-antitoxin inShewanella oneidensis

(2015) Jianyun Yao et al.   Microbial Biotechnology

RalR (a DNase) and RalA (a small RNA) form a type I toxin–antitoxin system in Escherichia coli

(2014) Yunxue Guo et al.   NUCLEIC ACIDS RESEARCH

A widespread bacteriophage abortive infection system functions through a Type IV toxin–antitoxin mechanism

(2014) Ron L. Dy et al.   NUCLEIC ACIDS RESEARCH

de novo Synthesis of a Bacterial Toxin/Antitoxin System

(2014) Valerie W. C. Soo et al.   Scientific Reports

Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing

(2013) Vivek Anantharaman et al.   Biology Direct

Molecular Mechanism of Bacterial Persistence by HipA

(2013) Elsa Germain et al.   MOLECULAR CELL

Structural Basis of mRNA Recognition and Cleavage by Toxin MazF and Its Regulation by Antitoxin MazE in Bacillus subtilis

(2013) Dhirendra K. Simanshu et al.   MOLECULAR CELL

A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp

(2013) Christopher D. Aakre et al.   MOLECULAR CELL

Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning

(2013) Hila Sberro et al.   MOLECULAR CELL

HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase

(2013) Ilana Kaspy et al.   Nature Communications

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

(2012) Xiaoxue Wang et al.   Nature Chemical Biology

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Assembly Dynamics and Stability of the Pneumococcal Epsilon Zeta Antitoxin Toxin (PezAT) System fromStreptococcus pneumoniae

(2010) Hannes Mutschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB

(2009) Martin Overgaard et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Translation and Cell Death: The Role of Rare tRNAs in Biofilm Formation and in Activating Dormant Phage Killer Genes

(2008) Rodolfo García-Contreras et al.   PLoS One