Expression, purification and crystallization of CLK1 kinase – A potential target for antiviral therapy

Targeting Kinase Interaction Networks: A New Paradigm in PPI Based Design of Kinase Inhibitors

(2019) Pranitha Jenardhanan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Regulation of influenza A virus mRNA splicing by CLK1

(2019) Anita Artarini et al.   ANTIVIRAL RESEARCH

An open library of human kinase domain constructs for automated bacterial expression

(2018) Steven K. Albanese et al.   BIOCHEMISTRY

High yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer

(2018) Siddhant Bhoir et al.   Scientific Reports

Novel CLK1 inhibitors based on N -aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands

(2017) Miroslav Murár et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

(2017) Talita D. Melo-Hanchuk et al.   Scientific Reports

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

(2016) Alexander Karlas et al.   Nature Communications

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

(2015) Mian Zu et al.   MOLECULES

Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2

(2014) Ana M. Garrote et al.   Acta Crystallographica Section F-Structural Biology Communications

Production of prone-to-aggregate proteins

(2013) Mario Lebendiker et al.   FEBS LETTERS

Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function

(2013) Raymond W. Wong et al.   NUCLEIC ACIDS RESEARCH

System-based drug discovery within the human kinome

(2012) Paul Bamborough   Expert Opinion on Drug Discovery

ID29: a high-intensity highly automated ESRF beamline for macromolecular crystallography experiments exploiting anomalous scattering

(2012) Daniele de Sanctis et al.   JOURNAL OF SYNCHROTRON RADIATION

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

(2011) Oleg Fedorov et al.   CHEMISTRY & BIOLOGY

Bacterial expression and purification of active hematopoietic cell kinase

(2011) Romana Kristelly et al.   PROTEIN EXPRESSION AND PURIFICATION

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

(2011) Raymond Wong et al.   Retrovirology

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

(2009) Alex N. Bullock et al.   STRUCTURE

RNA interference screen for human genes associated with West Nile virus infection

(2008) Manoj N. Krishnan et al.   NATURE