The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture

Lasting organ-level bone mechanoadaptation is unrelated to local strain

(2020) Behzad Javaheri et al.   Science Advances

Third harmonic generation imaging and analysis of the effect of low gravity on the lacuno-canalicular network of mouse bone

(2019) Rachel Genthial et al.   PLoS One

The phylogenetic origin and evolution of acellular bone in teleost fishes: insights into osteocyte function in bone metabolism

(2019) Donald Davesne et al.   BIOLOGICAL REVIEWS

Canalicular Junctions in the Osteocyte Lacuno-Canalicular Network of Cortical Bone

(2019) Nina Kølln Wittig et al.   ACS Nano

Changes in the osteocyte lacunocanalicular network with aging

(2019) LeAnn M. Tiede-Lewis et al.   BONE

Towards a Connectomic Description of the Osteocyte Lacunocanalicular Network in Bone

(2019) Richard Weinkamer et al.   Current Osteoporosis Reports

The contribution of the pericanalicular matrix to mineral content in human osteonal bone

(2019) A. Roschger et al.   BONE

Integrins in Osteocyte Biology and Mechanotransduction

(2019) Ivor P. Geoghegan et al.   Current Osteoporosis Reports

Investigating Osteocytic Perilacunar/Canalicular Remodeling

(2019) Cristal S. Yee et al.   Current Osteoporosis Reports

The murine axial compression tibial loading model to study bone mechanobiology: Implementing the model and reporting results

(2019) Russell P. Main et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples

(2019) David Hörl et al.   NATURE METHODS

Network architecture strongly influences the fluid flow pattern through the lacunocanalicular network in human osteons

(2019) Alexander F. van Tol et al.   Biomechanics and Modeling in Mechanobiology

Advances in self-healing materials based on vascular networks with mechanical self-repair characteristics

(2018) Min Wook Lee et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Age-related changes in female mouse cortical bone microporosity

(2018) Haniyeh Hemmatian et al.   BONE

Microstructural changes associated with osteoporosis negatively affect loading-induced fluid flow around osteocytes in cortical bone

(2018) Vittorio Gatti et al.   JOURNAL OF BIOMECHANICS

The small world of osteocytes: connectomics of the lacuno-canalicular network in bone

(2017) Philip Kollmannsberger et al.   NEW JOURNAL OF PHYSICS

Label-free imaging of bone multiscale porosity and interfaces using third-harmonic generation microscopy

(2017) Rachel Genthial et al.   Scientific Reports

Tomography-Based Quantification of Regional Differences in Cortical Bone Surface Remodeling and Mechano-Response

(2016) Annette I. Birkhold et al.   CALCIFIED TISSUE INTERNATIONAL

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

(2016) Marios Georgiadis et al.   Journal of the Royal Society Interface

Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix

(2016) Sithara S. Wijeratne et al.   MATRIX BIOLOGY

Remnant Woven Bone and Calcified Cartilage in Mouse Bone: Differences between Ages/Sex and Effects on Bone Strength

(2016) Victoria Ip et al.   PLoS One

The Periosteal Bone Surface is Less Mechano-Responsive than the Endocortical

(2016) Annette I. Birkhold et al.   Scientific Reports

Skeletal maturity leads to a reduction in the strain magnitudes induced within the bone: A murine tibia study

(2015) Hajar Razi et al.   Acta Biomaterialia

Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis

(2015) Stefaan W. Verbruggen et al.   BIOPHYSICAL JOURNAL

Monitoring in vivo (re)modeling: A computational approach using 4D microCT data to quantify bone surface movements

(2015) Annette I. Birkhold et al.   BONE

Quantifying the osteocyte network in the human skeleton

(2015) Pascal R. Buenzli et al.   BONE

Blood and interstitial flow in the hierarchical pore space architecture of bone tissue

(2015) Stephen C. Cowin et al.   JOURNAL OF BIOMECHANICS

Peak strain magnitudes and rates in the tibia exceed greatly those in the skull: An in vivo study in a human subject

(2015) Richard A Hillam et al.   JOURNAL OF BIOMECHANICS

Aging Leads to a Dysregulation in Mechanically Driven Bone Formation and Resorption

(2015) Hajar Razi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix

(2015) Pascal R. Buenzli   JOURNAL OF THEORETICAL BIOLOGY

The influence of age on adaptive bone formation and bone resorption

(2014) Annette I. Birkhold et al.   BIOMATERIALS

Synchrotron X-ray phase nano-tomography-based analysis of the lacunar–canalicular network morphology and its relation to the strains experienced by osteocytes in situ as predicted by case-specific finite element analysis

(2014) Peter Varga et al.   Biomechanics and Modeling in Mechanobiology

Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia

(2014) T. J. Vaughan et al.   Biomechanics and Modeling in Mechanobiology

Mineralizing surface is the main target of mechanical stimulation independent of age: 3D dynamic in vivo morphometry

(2014) Annette I. Birkhold et al.   BONE

Remodeling in bone without osteocytes: Billfish challenge bone structure–function paradigms

(2014) Ayelet Atkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach

(2013) Stefaan W. Verbruggen et al.   Biomechanics and Modeling in Mechanobiology

Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load

(2013) Bettina M. Willie et al.   BONE

Osteocytes: Master Orchestrators of Bone

(2013) Mitchell B. Schaffler et al.   CALCIFIED TISSUE INTERNATIONAL

Local Mechanical Stimuli Regulate Bone Formation and Resorption in Mice at the Tissue Level

(2013) Friederike A. Schulte et al.   PLoS One

Interstitial fluid flow within bone canaliculi and electro-chemo-mechanical features of the canalicular milieu

(2012) Vittorio Sansalone et al.   Biomechanics and Modeling in Mechanobiology

Mechanosensation and transduction in osteocytes

(2012) Jenneke Klein-Nulend et al.   BONE

Emerging role of primary cilia as mechanosensors in osteocytes

(2012) An M. Nguyen et al.   BONE

Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model

(2012) Hiroshi Kamioka et al.   Integrative Biology

Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone

(2010) William R Thompson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

The organization of the osteocyte network mirrors the extracellular matrix orientation in bone

(2010) Michael Kerschnitzki et al.   JOURNAL OF STRUCTURAL BIOLOGY

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

(2010) S. Burra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Healing Materials with Interpenetrating Microvascular Networks

(2009) Christopher J. Hansen et al.   ADVANCED MATERIALS

Recent advances and new opportunities in lung mechanobiology

(2009) Daniel J. Tschumperlin et al.   JOURNAL OF BIOMECHANICS

Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction

(2008) Susannah P. Fritton et al.   Annual Review of Fluid Mechanics

Idealization of pericellular fluid space geometry and dimension results in a profound underprediction of nano-microscale stresses imparted by fluid drag on osteocytes

(2008) Eric J. Anderson et al.   JOURNAL OF BIOMECHANICS