Biotransformation and bioactivation reactions – 2015 literature highlights

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans

(2016) Filippo Fiorentini et al.   ACS Chemical Biology

Hepatic Metabolism of Carcinogenic β-Asarone

(2015) Alexander T. Cartus et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

(2015) Seigo Sanoh et al.   Drug Metabolism and Pharmacokinetics

Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice

(2015) Yoshifumi Hagiya et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Impact of Structural and Metabolic Variations on the Toxicity and Carcinogenicity of Hydroxy- and Alkoxy-Substituted Allyl- and Propenylbenzenes

(2014) I. M. C. M. Rietjens et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Novel drugs against tuberculosis: a clinician's perspective

(2014) Ioana Diana Olaru et al.   EUROPEAN RESPIRATORY JOURNAL

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldehyde oxidase and its importance in novel drug discovery: present and future challenges

(2013) Enrico Garattini et al.   Expert Opinion on Drug Discovery

Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes

(2012) Kaoru Kobayashi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Unexpected renal toxicity associated with SGX523, a small molecule inhibitor of MET

(2012) Jeffrey R. Infante et al.   INVESTIGATIONAL NEW DRUGS

Tutorial on physiologically based kinetic modeling in molecular nutrition and food research

(2011) Ivonne M. C. M. Rietjens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Characterization and Determination of Chloro- and Bromo-Benzoquinones as New Chlorination Disinfection Byproducts in Drinking Water

(2010) Yuli Zhao et al.   ANALYTICAL CHEMISTRY

A Baeyer-Villiger Oxidation Specifically Catalyzed by Human Flavin-Containing Monooxygenase 5

(2010) W. G. Lai et al.   DRUG METABOLISM AND DISPOSITION

A Toxic Disinfection By-product, 2,6-Dichloro-1,4-benzoquinone, Identified in Drinking Water

(2009) Feng Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biotransformation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Lung Tissue from Mouse, Rat, Hamster, and Man

(2009) Elmar Richter et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Analysis of Pyridyloxobutyl and Pyridylhydroxybutyl DNA Adducts in Extrahepatic Tissues of F344 Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

(2009) Siyi Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

(2009) Dennis A. Smith et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rapid detection and characterization of reactive drug metabolitesin vitrousing several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry

(2009) Timo Rousu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS

(2008) Jinchun Sun et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES