Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

(2016) Elsa M. Meylan et al.   NEUROPHARMACOLOGY

Modulating epigenetic HAT activity for reinstating acetylation homeostasis: A promising therapeutic strategy for neurological disorders

(2016) Shabir Ahmad Ganai et al.   PHARMACOLOGY & THERAPEUTICS

Increased histone deacetylase activity in peripheral blood mononuclear cells of patients with schizophrenia

(2016) Bo Pang et al.   PSYCHIATRY RESEARCH

Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats

(2015) Roger B. Varela et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Prospects for the development of epigenetic drugs for CNS conditions

(2015) Moshe Szyf   NATURE REVIEWS DRUG DISCOVERY

Valproic acid (VPA) reduces sensorimotor gating deficits and HDAC2 overexpression in the MAM animal model of schizophrenia

(2015) Ewelina Bator et al.   Pharmacological Reports

Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain

(2015) Jéssica Lopes-Borges et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Valproate augmentation in a subgroup of patients with treatment-resistant unipolar depression

(2015) Maykel F. Ghabrash et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene

(2015) Y. B. Wei et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

(2014) F. A. Schroeder et al.   ACS Chemical Neuroscience

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

(2014) Johannes Gräff et al.   CELL

Effect of microinjecting of 5-aza-2-deoxycytidine into ventrolateral orbital cortex on depressive-like behavior in rats

(2014) Bo Xing et al.   NEUROSCIENCE LETTERS

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

(2013) Frederick A. Schroeder et al.   PLoS One

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

(2012) Mitsumasa Kurita et al.   NATURE NEUROSCIENCE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy

(2012) Mark J. Millan   NEUROPHARMACOLOGY

Valproate Alters Dopamine Signaling in Association with Induction of Par-4 Protein Expression

(2012) Saebom Lee et al.   PLoS One

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, Part 2: Update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects

(2012) Alkomiet Hasan et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors

(2011) Amanda J Sales et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Epigenetic mechanisms and cancer: An interface between the environment and the genome

(2011) Zdenko Herceg et al.   Epigenetics

Neuroanatomical Profile of Antimaniac Effects of Histone Deacetylases Inhibitors

(2011) Camila O. Arent et al.   MOLECULAR NEUROBIOLOGY

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase  3 sodium pump

(2011) G. S. Kirshenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus

(2011) Yosuke Yamawaki et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Epigenetic management of major psychosis

(2011) Jacob Peedicayil   Clinical Epigenetics

Valproate induces DNA demethylation in nuclear extracts from adult mouse brain

(2010) Erbo Dong et al.   Epigenetics

Evaluation of citrate synthase activity in brain of rats submitted to an animal model of mania induced by ouabain

(2010) Tiago P. Freitas et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

(2010) Evan Elliott et al.   NATURE NEUROSCIENCE

Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression

(2010) Leisa A. Glantz et al.   SCHIZOPHRENIA RESEARCH

Mechanisms of transcriptional repression by histone lysine methylation

(2009) Philip Hublitz et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation ofBdnfgene promoter 1

(2009) Feng Tian et al.   JOURNAL OF NEUROCHEMISTRY

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population

(2009) David P. Gavin et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Altered gene expression of histone deacetylases in mood disorder patients

(2009) Teruyuki Hobara et al.   JOURNAL OF PSYCHIATRIC RESEARCH

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

(2009) Tatjana Perisic et al.   NEUROPSYCHOPHARMACOLOGY

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment

(2009) Amy M. Dworkin et al.   SEMINARS IN CANCER BIOLOGY

Histone methyltransferases in cancer

(2009) Mareike Albert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epigenetics, genomic mutations and cognitive function

(2009) Abraham Reichenberg et al.   Cognitive Neuropsychiatry

Histone modifying enzymes: Structures, mechanisms, and specificities

(2008) Ronen Marmorstein et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

GABAA Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes

(2008) Michael O. Poulter et al.   BIOLOGICAL PSYCHIATRY

Epigenetics in the Nervous System

(2008) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (-)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)

(2008) M. J. Fell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chromatin, cancer and drug therapies

(2008) Connie C. Cortez et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

Decoding the Epigenetic Language of Neuronal Plasticity

(2008) Emiliana Borrelli et al.   NEURON

Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model

(2008) H.-L. Feng et al.   NEUROSCIENCE

Epigenomics and breast cancer

(2008) Pang-Kuo Lo et al.   PHARMACOGENOMICS

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection

(2007) Rajiv P. Sharma et al.   SCHIZOPHRENIA RESEARCH