Article
Instruments & Instrumentation
Xingcheng Jin, Xiaoli Xia, Jiaying Li, Michael Adu-Frimpong, Xiaowen Wang, Qilong Wang, Huaxiao Wu, Qingtong Yu, Hao Ji, Elmurat Toreniyazov, Xia Cao, Jiangnan Yu, Ximing Xu
Summary: Ulcerative colitis (UC) has become a global disease due to its high incidence. This study aimed to improve the oral bioavailability of hyperoside (HYP) and evaluate its therapeutic effect on UC by developing HYP-loaded mixed micelles (HYP-M). The results demonstrated that HYP-M exhibited stable physical and chemical properties, smaller particle size, and higher oral bioavailability compared to free HYP.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Armando A. Roca A. Suarez, Enkhtuul Batbold, Birke Bartosch, Naranjargal Dashdorj, Barbara Testoni, Fabien Zoulim
Summary: Hepatitis delta virus (HDV) is a satellite RNA virus that requires hepatitis B virus (HBV) for replication. Co-infection with HDV/HBV leads to faster disease progression compared to HBV mono-infection. Developing antiviral therapies targeting HDV is crucial. Evaluating promising HDV-specific drugs and combination therapies, as well as exploring anti-HBV drugs with potential effects against HDV, are key areas of research.
LIVER INTERNATIONAL
(2023)
Article
Food Science & Technology
Xiaoli Liu, Liuqing Chen, Yanan Kang, Dong He, Bingxin Yang, Kegang Wu
Summary: Nanoemulsion formulations of essential oils can enhance their water solubilities and antimicrobial activities. The study on cinnamon essential oil nanoemulsions showed that they inhibited the growth of various foodborne pathogens, with Gram-negative bacteria being more sensitive to the nanoemulsions than Gram-positive bacteria.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Monica Argenziano, Irfan Aamer Ansari, Elisabetta Muntoni, Rita Spagnolo, Anna Scomparin, Roberta Cavalli
Summary: This study aims to improve the antioxidant activity and bioavailability of trans-resveratrol by developing lipid-coated nanocrystals. The nanocrystals obtained through a milling method showed faster dissolution rate compared to the coarse powder and did not impair the antioxidant properties of trans-resveratrol. Oral administration of the lipid-coated nanocrystals to rats resulted in increased bioavailability of trans-resveratrol.
Article
Pharmacology & Pharmacy
Rita Ambrus, Areen Alshweiat, Piroska Szabo-Revesz, Csilla Bartos, Ildiko Csoka
Summary: Nanocrystals of meloxicam (MLX) were prepared using the bead mill method and high-pressure homogenization. Different drying methods and cryoprotectants were applied to obtain dry nanocrystals. The results showed that freeze-dried samples had the smallest particle size, mannitol-based samples had the highest crystallinity index, and trehalose-based samples had the lowest crystallinity index. These factors explained the differences in dissolution among the samples.
Article
Chemistry, Applied
Xiaosong Zhai, Yamei Xiang, Yaning Tian, Aiyue Wang, Zisong Li, Wentao Wang, Hanxue Hou
Summary: In this study, cellulose nanocrystals (CNCs) were extracted from cotton-derived microcrystalline cellulose (MCC) using enzymatic hydrolysis-assisted high-pressure homogenization. The CNCs showed needle-like shape with a length of 100-250 nm and a width of 5-10 nm, and had a particle size range of 3-80 nm. The extracted CNCs exhibited slightly lower crystallinity and higher thermal stability compared to MCC, making them a promising reinforcing agent in biodegradable packaging materials.
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Weiming Xu, Yijun Niu, Xin Ai, Chengjie Xia, Ping Geng, Haiyan Zhu, Wei Zhou, Hai Huang, Xunlong Shi
Summary: This study constructed a novel liver-targeted baicalin liposome to enhance the bioavailability and antiviral ability of baicalin. The results showed that the liposomes significantly improved cellular uptake and specific distribution in the liver, leading to substantial inhibitory effects on HBV molecules. The enhanced efficacy was attributed to the interaction between hepatocyte nuclear factors and estrogen receptors.
Article
Biochemistry & Molecular Biology
Yan Liu, Yuwan Li, Lei Rao, Yongtao Wang, Xiaojun Liao
Summary: This study investigated the effects of high pressure homogenization (HPH) on the interaction between corn starch and cyanidin-3-O-glucoside. The results showed that the interaction was strongest at low temperatures and low pressures. HPH opened the entry channels, increased contact area, and preserved steric hindrance, which increased hydrogen bonding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Qingzhi Huang, Tao Hong, Mingjing Zheng, Yuanfan Yang, Yanbing Zhu, Zedong Jiang, Hui Ni, Qingbiao Li
Summary: In this study, the effect of high-pressure homogenization (HPH) on the composition, properties, and activity of dietary fiber from B. fusco-purpurea seaweed was investigated. HPH significantly increased water-soluble dietary fiber content and improved the functional properties of BDF. Additionally, HPH enhanced the in vitro antiglycation activity of BDF by inhibiting the formation of AGEs and mitigating damage induced by AGEs on intestinal cells. These findings highlight the potential of HPH in seaweed processing and utilization.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Minwoo Lee, Minhaeng Heo, Hyunho Lee, Jihoon Shin
Summary: The isolation degree of cellulose nanocrystals (CNCs) suspensions can be estimated through turbidimetry, surface charge, and dispersion analysis. Different raw cellulosic materials show significant changes in CNCs isolation degree and turbidity after the same treatment, indicating a direct correlation between yield, turbidity, surface charge, and sedimentation of CNCs suspensions.
Article
Pharmacology & Pharmacy
Guangshuai Zhang, Guangyuan Sun, Haishan Guan, Mo Li, Yanhua Liu, Baocheng Tian, Zhonggui He, Qiang Fu
Summary: The study aimed to improve the therapeutic efficacy of naringenin by formulating it into nanocrystals, showing promising results in enhancing bioavailability, cellular uptake, and rheumatoid arthritis treatment.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Manuel Alejandro Uranga-Soto, Manuel Alejandro Vargas-Ortiz, Josefina Leon-Felix, Jose Basilio Heredia, Maria Dolores Muy-Rangel, Dominique Chevalier-Lucia, Laetitia Picart-Palmade
Summary: The effects of hydrostatic and dynamic high-pressure treatments on the activity of enzymes and physicochemical attributes of mango nectar were evaluated. The results showed that each high-pressure technology had different effects on viscosity, color, and enzyme activity, suggesting the importance of selecting the appropriate processing system for liquid foods.
Article
Food Science & Technology
Atiyeh Heidary, Nafiseh Soltanizadeh
Summary: The aim of this study was to investigate the effects of high-pressure homogenization (HPH) on the functional, physicochemical, and structural properties of gelatin. The results showed that HPH could destroy hydrogen bonds and lead to protein unfolding. The microstructure of gelatin gel was altered, and the emulsifying and foaming properties of gelatin were improved after HPH treatment.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Food Science & Technology
Zhiwei Kang, Shan Chen, Yan Zhou, Sadeeq Ullah, Hao Liang
Summary: In this study, citrus essential oil nanoemulsion with improved antimicrobial activity was successfully prepared using high-pressure homogenization method. The effects of temperature, pH, ionic strength, and storage time on the physicochemical properties of the nanoemulsion were investigated. The results showed that the nanoemulsion exhibited significantly enhanced antibacterial activity against Staphylococcus aureus and Bacillus subtilis compared to pure citrus essential oil. This research provides valuable insights for the development of nanoencapsulation techniques and food preservation.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Chemistry, Applied
Changling Wu, David Julian McClements, Mingyu He, Li Zheng, Tian Tian, Fei Teng, Yang Li
Summary: Nanocellulose was isolated from okara using ultrasound and high-pressure homogenization treatments, with detailed characterization of its physical-chemical and structural properties. The treated cellulose material exhibited a small particle diameter, high crystallinity, and swelling ratio, suitable for various food and non-food applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Qingqing Xiao, Xiaotong Li, Chang Liu, Yuxin Jiang, Yonglong He, Wanting Zhang, Helena S. Azevedo, Wei Wu, Yuanzheng Xia, Wei He
Summary: In this study, researchers combined a targeted diterpenoid derivative with an anti-CTLA-4 checkpoint blockade to improve immunotherapy. The use of thermosensitive liposomes as carriers allowed for the co-delivery of the two drug payloads into the tumor, resulting in enhanced immune response and therapeutic effect. Additionally, the diterpenoid derivative also improved the immunotherapeutic effect of the anti-PD-1 checkpoint antibody.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Lingyu Hang, Chengying Shen, Yuye Xue, Wei Wu, Baode Shen, Hailong Yuan
Summary: Nanotechnology is a primary strategy to enhance the oral bioavailability of poorly water soluble drugs. This study tracks the translocation of oral herpetrione amorphous nanoparticles and finds that most nanoparticles are degraded or absorbed in the gastrointestinal tract, with fluorescent signals observed in the gastrointestinal tract and liver. Only a small amount of the nanoparticles penetrate cell monolayers.
JOURNAL OF DRUG TARGETING
(2023)
Review
Pharmacology & Pharmacy
Yuehong Ren, Wei Wu, Xingwang Zhang
Summary: Targeted drug delivery is being constantly improved based on a better understanding of diseases. Oral delivery of particulates is challenging due to biochemical aggressivity and immune exclusion in the gut. The feasibility of oral targeting to remote sites beyond the gastrointestinal tract is still not clear. The limited evidence and lack of quantification of systemically exposed particles do not support the success of oral targeting, but the lymphatic pathway may provide an alternative portal for peroral particles to reach remote target sites.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biotechnology & Applied Microbiology
Kaiheng Liu, Wenjuan Liu, Zirong Dong, Luyu Zhang, Qiuyu Li, Renjie Zhang, Haisheng He, Yi Lu, Wei Wu, Jianping Qi
Summary: This study utilized enteric mesoporous silica nanoparticles to load ionic liquids, improving oral drug delivery. The in vitro experiments showed enhanced oral absorption of the drugs, suggesting the potential of this platform for delivering poorly water-soluble drugs and biologics orally.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Yuze Sheng, Zhongjian Chen, Wei Wu, Yi Lu
Summary: Biofilms are colonies of microorganisms embedded in extracellular polymeric substances (EPS) that cause antibiotic resistance and persistent bacterial infections. Nanoparticles (NPs) can enhance the inhibition and eradication of biofilms by delivering antibiotics with improved EPS penetration and localized drug concentration. Novel strategies such as size optimization, surface modification, stimuli-triggered release, and combined approaches are being developed to further enhance the antibiofilm capacity of NPs. Therefore, NPs offer an effective and promising approach to combat biofilms.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Multidisciplinary
Ni Dong, Zhenyun Liu, Haisheng He, Yi Lu, Jianping Qi, Wei Wu
Summary: In this study, different shapes of red blood cell membrane-coated mesoporous silica nanoparticles were synthesized to verify the concept of multivalent interactions. The experiments demonstrated strengthened binding and internalization of disk-shaped particles with cells, further confirming the significance of multivalent interactions in enhancing active targeting efficiency.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Huazhang Lai, Shuiyan Chen, Xiaoyu Su, Xiaoying Huang, Qin Zheng, Ming Yang, Baode Shen, Pengfei Yue
Summary: To enhance the sustained release and long-term antibacterial activity of Chimonanthus nitens Oliv. essential oil (CEO), novel sponge-like nanoporous silica particles (SNP) were developed as a carrier for loading CEO. The results showed that SNP had a high loading capability of CEO (76.3%) and improved the thermal stability and release behavior of CEO. CEO-SNP exhibited strong antibacterial activity against S. aureus, E. coli, and P. aeruginosa, even after storage for 30 days at 25 °C. Thus, sponge-like silica nanoporous particles showed promise as a carrier for stable and antibacterial delivery of CEO.
Article
Medicine, Research & Experimental
Fulong Man, Yinqian Yang, Haisheng He, Jianping Qi, Wei Wu, Yi Lu
Summary: We attempted to establish an in vitro dissolution protocol that is similar to in vivo dissolution by physically embedding aggregation-caused quenching (ACQ) fluorophores inside the lattice of aripiprazole (APZ) crystals. The fluorescence of the fluorophore illuminated the APZ crystals but was quenched upon dissolution of APZ-HCs, allowing for real-time monitoring of intact APZ-HCs. The good correlation between fluorescent quenching and dissolution justified reliable quantification of intact APZ crystals. By comparing the residual percentage of fluorescence intensity in rats treated with APZ-HCs over time, which was converted to in vivo dissolution, the in vitro dissolution profile of APZ was established with a similarity factor larger than 50 compared to in vivo dissolution.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Qiuyue Liu, Jiahui Zou, Zhongjian Chen, Wei He, Wei Wu
Summary: This review elaborates on the development trends of nanomedicines, emerging nanocarriers, in vivo fate and safety of nanomedicines, and their extensive applications. The potential challenges and obstacles hindering the clinical translation of nanomedicines are also discussed. It provides a comprehensive overview of research activities in the field of nanomedicines.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Yuze Sheng, Qin Yu, Yanping Huang, Quangang Zhu, Zhongjian Chen, Wei Wu, Tao Yi, Yi Lu
Summary: Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs. Drug NCs have been used as solid emulsifiers to prepare nanocrystal self-stabilized Pickering emulsions (NCSSPEs), which can increase drug loading and reduce side effects. These emulsions impede the dissolution of drug NCs and can further enhance their oral bioavailability, especially for BCS IV drugs. In this study, CUR-NCs stabilized Pickering emulsions were prepared using either indigestible or digestible oils. The emulsions significantly increased the oral bioavailability of CUR-NCs, with the digestibility of the oil phase affecting the intactness of the NCs.
Article
Chemistry, Multidisciplinary
Xin Wu, Xinmei Chen, Xinyu Wang, Haisheng He, Jianming Chen, Wei Wu
Summary: Paclitaxel-loaded liposomes hold potential for the treatment of breast carcinoma and other cancers. By conjugating paclitaxel with lipids of different chain lengths, the drug release and enzymatic conversion rates can be controlled, affecting the pharmacokinetics, tumor accumulation, and anti-tumor efficacy of liposomal paclitaxel.
CHINESE CHEMICAL LETTERS
(2024)
Article
Endocrinology & Metabolism
Wei Wu, Chunxiu Gong, Yuchuan Li, Yuhua Hu, Haihong Gong, Junfen Fu, Ke Huang, Pin Li, Xiaoping Luo
Summary: This study assessed the long-term efficacy and safety of growth hormone (GH) treatment in Chinese children born small for gestational age (SGA). The results showed that long-term GH treatment was effective at improving height in these children, with normal glucose metabolism and thyroid function throughout the treatment.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zhi-Ping Jin, Miao Yan, Si-Ze Li, Bao-Qing Wang, Qing Xu, Wei Wu, Xiao-Yu Li, Qian-Zhou Lv, Xiao-Qiang Xiang
Summary: This study used physiologically based pharmacokinetics (PBPK) models to predict the impact of CYP2C19 polymorphism on the drug-drug interactions (DDIs) between voriconazole and tacrolimus. It was found that voriconazole immediately increased tacrolimus concentration in all population. The simulated duration of DDIs disappearance after voriconazole withdrawal were 146h, 90h and 66h in poor metabolizers (PMs), intermediate metabolizers (IMs) and extensive metabolizers(EMs), respectively. The developed and optimized PBPK models in this study can be applied to assist the dose adjustment for tacrolimus with and without voriconazole.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xin Ji, Yifan Cai, Xiaochun Dong, Wei Wu, Weili Zhao
Summary: To develop and optimize nano drug delivery systems (NDDSs), understanding their in vivo fate is crucial. P2 (Aza-BODIPY) and P4 (BODIPY) have been found to be useful in unraveling the biofate of nanoparticles due to their water-sensitive emission. However, it has been observed that quenched ACQ probe aggregates can repartition into hydrophobic physiologically relevant constituents, resulting in fluorescence re-illumination. In this study, various fluorophores were screened for ACQ and their re-illumination performance, and Aza-BODIPY dyes were identified as advantageous options.
Article
Chemistry, Multidisciplinary
Yifan Cai, Xin Ji, Yunsen Zhang, Chang Liu, Zichen Zhang, Yongjiu Lv, Xiaochun Dong, Haisheng He, Jianping Qi, Yi Lu, Defang Ouyang, Weili Zhao, Wei Wu
Summary: Through structural modifications, probes with absolute ACQ and negligible re-illumination have been developed for accurate tracking of nanocarriers, showing excellent bioimaging performance.
