IL-20R Activation via rIL-19 Enhances Hematoma Resolution through the IL-20R1/ERK/Nrf2 Pathway in an Experimental GMH Rat Pup Model

A comprehensive review of therapeutic targets that induce microglia/macrophage-mediated hematoma resolution after germinal matrix hemorrhage

(2019) Jerry J. Flores et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rh-IFN-α attenuates neuroinflammation and improves neurological function by inhibiting NF-κB through JAK1-STAT1/TRAF3 pathway in an experimental GMH rat model

(2019) Peng Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Secukinumab attenuates reactive astrogliosis via IL‐17RA/(C/EBPβ)/SIRT1 pathway in a rat model of germinal matrix hemorrhage

(2019) Sheng‐Peng Liu et al.   CNS Neuroscience & Therapeutics

Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway

(2019) Md. Moniruzzaman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracerebral Hemorrhage–Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2

(2019) Liheng Bian et al.   Translational Stroke Research

Complex Clearance Mechanisms After Intraventricular Hemorrhage and rt-PA Treatment—a Review on Clinical Trials

(2019) Bert Bosche et al.   Translational Stroke Research

Astrogliosis inhibition attenuates hydrocephalus by increasing cerebrospinal fluid reabsorption through the glymphatic system after germinal matrix hemorrhage

(2019) Yan Ding et al.   EXPERIMENTAL NEUROLOGY

Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion

(2019) Ryo Ohtomo et al.   Translational Stroke Research

Propranolol diminished severity of rat EAE by enhancing immunoregulatory/protective properties of spinal cord microglia

(2019) Ivan Pilipović et al.   NEUROBIOLOGY OF DISEASE

Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization

(2019) Ladonya Jackson et al.   Translational Stroke Research

Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis inIl19−/−×Ldlr−/−Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R)Highlights

(2018) Mitali Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PPAR-γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage

(2018) Gaiqing Wang et al.   BEHAVIOURAL NEUROLOGY

Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2/AMPK/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats

(2018) Yixin Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

M1/M2 macrophages in diabetic nephropathy: Nrf2/HO-1 as therapeutic targets

(2018) R. Clive Landis et al.   CURRENT PHARMACEUTICAL DESIGN

Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain

(2018) Jui M. Dave et al.   DEVELOPMENTAL CELL

Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway

(2018) Xiuchun Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats

(2018) Weifeng Wan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model

(2018) Yiting Zhang et al.   NEUROBIOLOGY OF DISEASE

The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats

(2018) Motoki Tanaka et al.   Translational Stroke Research

Ras-Related C3 Botulinum Toxin Substrate 1 Promotes Axonal Regeneration after Stroke in Mice

(2018) Lin Liu et al.   Translational Stroke Research

Targeting Germinal Matrix Hemorrhage–Induced Overexpression of Sodium‐Coupled Bicarbonate Exchanger Reduces Posthemorrhagic Hydrocephalus Formation in Neonatal Rats

(2018) Qian Li et al.   Journal of the American Heart Association

IL-20 receptor cytokines in autoimmune diseases

(2018) Jun Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Interleukin-10 Family of Cytokines and Their Role in the CNS

(2018) Amanda R. Burmeister et al.   Frontiers in Cellular Neuroscience

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

(2018) Biaoxue Rong et al.   International Journal of Chronic Obstructive Pulmonary Disease

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes

(2017) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Haematoma scavenging in intracerebral haemorrhage: from mechanisms to the clinic

(2017) Gaiqing Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage

(2017) Che-Feng Chang et al.   NEUROBIOLOGY OF DISEASE

Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

(2017) Mustapha Imam et al.   Nutrients

CD163, a Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons

(2017) Thomas Garton et al.   Translational Stroke Research

IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages

(2016) Khatuna Gabunia et al.   AMERICAN JOURNAL OF PATHOLOGY

Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model

(2016) Yihao Tao et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-19 alleviates brain injury by anti-inflammatory effects in a mice model of focal cerebral ischemia

(2016) Weiying Xie et al.   BRAIN RESEARCH

Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups

(2016) Damon Klebe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats

(2016) Jerry J. Flores et al.   NEUROBIOLOGY OF DISEASE

Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage

(2016) Shenglong Cao et al.   STROKE

Role of Erythrocyte CD47 in Intracerebral Hematoma Clearance

(2016) Wei Ni et al.   STROKE

Interleukin-19 increases angiogenesis in ischemic hind limbs by direct effects on both endothelial cells and macrophage polarization

(2015) James Richards et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cerebrospinal Fluid Markers of Macrophage and Lymphocyte Activation After Traumatic Brain Injury in Children

(2015) Elizabeth Newell et al.   Pediatric Critical Care Medicine

Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models

(2015) Yu-Hsiang Hsu et al.   PLoS One

A Cannabinoid Receptor 2 Agonist Prevents Thrombin-Induced Blood–Brain Barrier Damage via the Inhibition of Microglial Activation and Matrix Metalloproteinase Expression in Rats

(2015) Lin Li et al.   Translational Stroke Research

Expression of interleukin (IL)-19 and IL-24 in inflammatory bowel disease patients: a cross-sectional study

(2014) G. Fonseca-Camarillo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Attenuation of Experimental Atherosclerosis by Interleukin-19

(2013) Stephen Ellison et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pathogenesis and Prevention of Intraventricular Hemorrhage

(2013) Praveen Ballabh   CLINICS IN PERINATOLOGY

The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging

(2013) Jens Haugbølle Thomsen et al.   Oxidative Medicine and Cellular Longevity

Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus

(2012) Tim Lekic et al.   EXPERIMENTAL NEUROLOGY

Interleukin-20 Promotes Migration of Bladder Cancer Cells through Extracellular Signal-regulated Kinase (ERK)-mediated MMP-9 Protein Expression Leading to Nuclear Factor (NF-κB) Activation by Inducing the Up-regulation of p21WAF1Protein Expression

(2012) Se-Jung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines

(2012) N. J. Logsdon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme Induces Heme Oxygenase 1 via Nrf2

(2011) Joseph J. Boyle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-19 as a Potential Therapeutic in Autoimmune and Inflammatory Diseases

(2011) Yasu-Taka Azuma et al.   CURRENT PHARMACEUTICAL DESIGN

Germinal Matrix Hemorrhage: Intraventricular Hemorrhage in Very-Low-Birth-Weight Infants

(2011) Luca A. Ramenghi et al.   STROKE

Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Intraventricular Hemorrhage in Premature Infants: Mechanism of Disease

(2009) Praveen Ballabh   PEDIATRIC RESEARCH