Harnessing nanotechnology to expand the toolbox of chemical biology

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Catalytic Mechanisms of Nanozymes and Their Applications in Biomedicine

(2019) Haijiao Dong et al.   BIOCONJUGATE CHEMISTRY

Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor

(2019) Abraham G. Beyene et al.   Science Advances

Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling

(2018) Yuting Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery

(2018) Barry A. Badeau et al.   Nature Chemistry

Quantitative self-assembly prediction yields targeted nanomedicines

(2018) Yosi Shamay et al.   NATURE MATERIALS

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant

(2018) Ryan M. Williams et al.   Science Advances

A Fluorescent Carbon Nanotube Sensor Detects the Metastatic Prostate Cancer Biomarker uPA

(2018) Ryan M. Williams et al.   ACS Sensors

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo

(2018) Thomas V. Galassi et al.   Science Translational Medicine

Selective Nanoparticle Targeting of the Renal TubulesNovelty and Significance

(2017) Ryan M. Williams et al.   HYPERTENSION

High-resolution imaging of cellular dopamine efflux using a fluorescent nanosensor array

(2017) Sebastian Kruss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

(2017) Daniela Schmid et al.   Nature Communications

Towards clinically translatable in vivo nanodiagnostics

(2017) Seung-min Park et al.   Nature Reviews Materials

A carbon nanotube reporter of microRNA hybridization events in vivo

(2017) Jackson D. Harvey et al.   Nature Biomedical Engineering

Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold

(2016) Guoliang Ke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clinically Approved Nanoparticle Imaging Agents

(2016) A. S. Thakor et al.   JOURNAL OF NUCLEAR MEDICINE

Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain

(2016) Antoine G. Godin et al.   Nature Nanotechnology

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury

(2016) Simone Alidori et al.   Science Translational Medicine

Recent applications of carbon nanomaterials in fluorescence biosensing and bioimaging

(2015) Jia Wen et al.   CHEMICAL COMMUNICATIONS

Carbon quantum dots and their applications

(2015) Shi Ying Lim et al.   CHEMICAL SOCIETY REVIEWS

Dual-Mode Ultrasensitive Quantification of MicroRNA in Living Cells by Chiroplasmonic Nanopyramids Self-Assembled from Gold and Upconversion Nanoparticles

(2015) Si Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium

(2015) Ryan M. Williams et al.   NANO LETTERS

Self-assembling biomolecular catalysts for hydrogen production

(2015) Paul C. Jordan et al.   Nature Chemistry

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

Hyperspectral Microscopy of Near-Infrared Fluorescence Enables 17-Chirality Carbon Nanotube Imaging

(2015) Daniel Roxbury et al.   Scientific Reports

Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs

(2014) Thiruganesh Ramasamy et al.   Acta Biomaterialia

Insight into nanoparticle cellular uptake and intracellular targeting

(2014) Basit Yameen et al.   JOURNAL OF CONTROLLED RELEASE

A Modular Labeling Strategy for In Vivo PET and Near-Infrared Fluorescence Imaging of Nanoparticle Tumor Targeting

(2014) C. Perez-Medina et al.   JOURNAL OF NUCLEAR MEDICINE

Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors

(2014) Daishun Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

(2014) Jie Li et al.   Nature Chemical Biology

Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes

(2014) D. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avidity Modulation of Folate-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles

(2013) Justin E. Silpe et al.   ACS Chemical Biology

Highly Efficient Phase Boundary Biocatalysis with Enzymogel Nanoparticles

(2013) Olena Kudina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The combined effects of size and surface chemistry on the accumulation of boronic acid-rich protein nanoparticles in tumors

(2013) Jing Wang et al.   BIOMATERIALS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes

(2013) Nicole M. Iverson et al.   Nature Nanotechnology

Design and development of fluorescent nanostructures for bioimaging

(2013) Mengjun Chen et al.   PROGRESS IN POLYMER SCIENCE

Signal amplification using functional nanomaterials for biosensing

(2012) Jianping Lei et al.   CHEMICAL SOCIETY REVIEWS

Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates

(2012) Manjeet Deshmukh et al.   JOURNAL OF CONTROLLED RELEASE

Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes

(2012) Ran Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nonendocytic Delivery of Functional Engineered Nanoparticles into the Cytoplasm of Live Cells Using a Novel, High-Throughput Microfluidic Device

(2012) Jungmin Lee et al.   NANO LETTERS

New approaches for dissecting protease functions to improve probe development and drug discovery

(2012) Edgar Deu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Controlling drug nanoparticle formation by rapid precipitation

(2011) Suzanne M. D'Addio et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticle Delivery of Cancer Drugs

(2011) Andrew Z. Wang et al.   Annual Review of Medicine

A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells

(2011) Lingyan Feng et al.   BIOMATERIALS

Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma

(2011) Miriam Benezra et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivobiodistribution of nanoparticles

(2011) Joao Paulo Mattos Almeida et al.   Nanomedicine

Nanoparticle PEGylation for imaging and therapy

(2011) Jesse V Jokerst et al.   Nanomedicine

Nanoparticles for intracellular-targeted drug delivery

(2011) Cristiana S O Paulo et al.   NANOTECHNOLOGY

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

Targeting kidney mesangium by nanoparticles of defined size

(2011) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Assembled Gold Nanoparticle Molecular Probes for Detecting Proteolytic Activity In Vivo

(2010) C. Jenny Mu et al.   ACS Nano

Graphene Fluorescence Resonance Energy Transfer Aptasensor for the Thrombin Detection

(2010) Haixin Chang et al.   ANALYTICAL CHEMISTRY

PET/NIRF/MRI triple functional iron oxide nanoparticles

(2010) Jin Xie et al.   BIOMATERIALS

Multiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube Raman tags in the near-infrared

(2010) Zhuang Liu et al.   Nano Research

A complementary definition of nanomaterial

(2010) Wolfgang G. Kreyling et al.   Nano Today

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzyme immobilization on Ag nanoparticles/polyaniline nanocomposites

(2009) Frank N. Crespilho et al.   BIOSENSORS & BIOELECTRONICS

Nanoparticles for direct nose-to-brain delivery of drugs

(2009) Alpesh Mistry et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging

(2009) Patricia Horcajada et al.   NATURE MATERIALS

Biofunctionalized targeted nanoparticles for therapeutic applications

(2008) Andrew Z Wang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Octaarginine- and Octalysine-modified Nanoparticles Have Different Modes of Endosomal Escape

(2008) Ayman El-Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Gold Nanoparticles Enable Molecular CT Imaging of Cancer

(2008) Rachela Popovtzer et al.   NANO LETTERS

Fluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine

(2008) Andrew A. Burns et al.   NANO LETTERS