Review
Biotechnology & Applied Microbiology
Feng Han, Qingchen Meng, En Xie, Kexin Li, Jie Hu, Qianglong Chen, Jiaying Li, Fengxuan Han
Summary: The incidence of tissue and organ damage caused by various diseases is increasing worldwide. Tissue engineering, using biomaterials with specific structures, has the potential to regenerate or replace damaged tissues and organs. Micro/nano materials, with their ability to mimic the microstructure of tissues, have greatly advanced the field of tissue engineering. This review provides an overview of different types of micro/nanomaterials, their preparation methods and their applications in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Wenbing Li, Junhao Liu, Lei Chen, Wanting Wei, Kun Qian, Yanju Liu, Jinsong Leng
Summary: This review introduces the micro/nano patterns in shape memory polymers and their preparation methods, explores their potential applications in different fields, and proposes future development directions and limitations.
Article
Chemistry, Multidisciplinary
Jacopo Oieni, Andrea Lolli, Domenico D'Atri, Nicole Kops, Avner Yayon, Gerjo J. V. M. van Osch, Marcelle Machluf
Summary: The study investigates the use of novel biomimetic nano-vesicles, Nano-Ghosts (NGs), for delivering ASOs to human mesenchymal stem cells (MSCs) and demonstrates their ability to effectively encapsulate and deliver miR-221 inhibitor, resulting in strong knock-down of miR-221 in vitro and in vivo. This approach expands the potential of NGs applications in drug delivery and regenerative medicine.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Polymer Science
Tingting Li, Liang Chen, Yu Yuan, Rengfei Shi
Summary: Bone defects may require grafting for repair, and shape memory polymers (SMPs) have gained attention in bone tissue engineering due to their excellent properties. We reviewed the various advantages of SMPs and their contribution to bone formation, especially in craniomaxillofacial and limb bones, providing new ideas for their application in bone tissue engineering.
Review
Polymer Science
Cheirmadurai Kalirajan, Amey Dukle, Arputharaj Joseph Nathanael, Tae-Hwan Oh, Geetha Manivasagam
Summary: This review summarizes recent advancements in the preparation of smart polymeric biomaterials with self-healing and shape memory properties. It also discusses novel approaches for developing various forms of polymeric biomaterials and highlights their applications in soft and hard tissue engineering. It underlines the future directions of polymeric biomaterials for successful clinical implications.
Article
Chemistry, Multidisciplinary
Hongqiu Wei, Bo Zhang, Ming Lei, Zhe Lu, Jupen Liu, Baolin Guo, You Yu
Summary: A straightforward and low-cost visible-lightmediated nano-biomineralization strategy was developed for rapid preparation of Biomineralized tough hydrogels (BTHs). This strategy allows for the improvement of mechanical and biological properties of BTHs, making them suitable for applications such as skin repair and bone regeneration.
Article
Chemistry, Multidisciplinary
Xulin Hu, Weiming Zhao, Zhen Zhang, Jianping Xie, Jian He, Jianfei Cao, Qing Li, Yajing Yan, Chengdong Xiong, Kainan Li
Summary: Biodegradable substitution materials for bone tissue engineering have been a significant research focus. In this study, a novel binary substitution material was developed by blending poly(lactic-acid)-co-(trimethylene-carbonate) and poly(glycolic-acid)-co-(trimethylene-carbonate) polymers. Porous scaffolds with uniform microstructure were fabricated using 3D extrusion printing technology. The results showed that the substitution material exhibited favorable biodegradability, mechanical properties, and shape-memory ability, making it a potential alternative for bone tissue engineering.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Shirin Nour, Rana Imani, Mehrnaz Mehrabani, Atefeh Solouk, Maryam Iranpour, Sasan Jalili-Firoozinezhad, Ali Mohammad Sharifi
Summary: By developing a hybrid double-layer nanofibrous scaffold loaded with niosomal Deferoxamine (NDFO), this study demonstrated enhanced angiogenesis and wound healing. The controlled and sustained release of DFO from the scaffold promoted vascular sprouting and accelerated wound healing both in vitro and in vivo. This biomimetic hybrid scaffold holds great promise for the treatment of full-thickness wounds and soft tissue regeneration.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Physical
Anabel Diaz-Arca, Patricia Ros-Tarraga, Maria J. Martinez Tome, Antonio H. De Aza, Luis Meseguer-Olmo, Patricia Mazon, Piedad N. De Aza
Summary: Micro-/nano-structured scaffolds with a weight composition of 46.6% alpha-tricalcium phosphate (α-TCP)-53.4% silicocarnotite (SC) were synthesized using the polymer replica method. The scaffolds showed well-identified surface nanostructures, non-cytotoxic effect on adult human mesenchymal stem cells (ah-MSCs), and successful grafting of alkaline phosphatase enzyme (ALP) for biological functionalization. Mimicking the natural cancellous bone, the scaffolds considered cell biology and biomolecule functionalization.
Review
Chemistry, Applied
Zia Ullah Arif, Muhammad Yasir Khalid, Ali Zolfagharian, Mahdi Bodaghi
Summary: 4D bioprinting is a next-generation additive manufacturing technology that allows for the construction of intricate and adaptive soft and hard tissue structures as well as biomedical devices. This is achieved through the use of stimuli-responsive materials, particularly shape memory polymers and hydrogels, which possess desirable biomechanical characteristics. This review provides an up-to-date overview of 4D bioprinting technology, including bioprinting materials, functionalities of biomaterials, and various tissue engineering and regenerative medicine applications.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Review
Chemistry, Analytical
Felicia Carotenuto, Sara Politi, Arsalan Ul Haq, Fabio De Matteis, Emanuela Tamburri, Maria Letizia Terranova, Laura Teodori, Alessandra Pasquo, Paolo Di Nardo
Summary: The failure of tissues and organs due to degenerative diseases or trauma is a major concern globally. Tissue engineering offers a potential solution by regenerating or replacing damaged tissues and organs. Biomaterials play a crucial role in promoting new tissue formation, with their architectural features influencing cellular behaviors. Optimizing the micro/nano architecture of biomaterials is essential for successful regenerative therapy. Various micro/nanostructured biomaterials have been developed to mimic the structure of different soft and hard tissues, with a focus on muscle, cartilage, and bone tissue regeneration.
Article
Chemistry, Multidisciplinary
Aixiang Ding, Oju Jeon, David Cleveland, Kaelyn L. Gasvoda, Derrick Wells, Sang Jin Lee, Eben Alsberg
Summary: 4D bioprinting is a promising technique for creating complex cell-laden constructs for tissue/organ regeneration. This study introduces a new single-component micro-flake hydrogel (MFH) system as a bioink for 4D bioprinting. The MFH exhibits scalable production, simple composition, and shear-thinning, shear-yielding, and rapid self-healing properties.
ADVANCED MATERIALS
(2022)
Editorial Material
Nanoscience & Nanotechnology
Maedeh Rahimnejad, Narges Nasrollahi Boroujeni, Sepideh Jahangiri, Navid Rabiee, Mohammad Rabiee, Pooyan Makvandi, Omid Akhavan, Rajender S. Varma
Summary: Efficient strategies for promoting microvascularization in vascular tissue engineering are limited. Utilizing nano- and micro-sized aggregates and spheres to mimic microvascular networks shows promise. Specific cell components and proangiogenic factors are necessary for this process.
NANO-MICRO LETTERS
(2021)
Review
Engineering, Biomedical
Wei Zhao, Chengbin Yue, Liwu Liu, Yanju Liu, Jinsong Leng
Summary: As a smart material, shape memory polymer (SMP) has great potential in the biomedical field. It offers superior adaptability, biocompatibility, adjustable biodegradability, and mechanical properties, making it ideal for medical devices. Additionally, 4D printing technology, based on smart materials and 3D printing, breaks through the technical barriers of personalized customization and provides new opportunities for biomedical development.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xi Chen, Shuyan Han, Weihui Wu, Zihan Wu, Yuan Yuan, Jun Wu, Changsheng Liu
Summary: The development of programmable functional biomaterials has added a new dimension, time, to 4D printing. This technology allows the morphology and function of printed constructs to change over time in response to environmental stimuli. In the field of orthopedics, 4D bioprinting using smart biomaterials has great potential for constructing dynamic and personalized bone tissue engineering scaffolds. This review discusses the advantages, applications, recent advancements, challenges, and future perspectives of 4D printing in bone regeneration.
Review
Engineering, Multidisciplinary
XiaoMeng Yang, JianWen Hou, Yuan Tian, JingYa Zhao, QiangQiang Sun, ShaoBing Zhou
Summary: Antibacterial surfaces, which rely on the nature of the material itself, play a significant role in ensuring safe food and water, human health, and industrial equipment. Preventing biofilm formation is an efficient approach to develop antibacterial surfaces, which can be achieved through repelling or killing bacteria. This review summarizes the fabrication methods and applications of antibacterial surfaces and presents several crucial points for developing long-term stable, no drug resistance, broad-spectrum, and even programable antibacterial surfaces.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Yang He, Mi Tian, Xilin Li, Jianwen Hou, Song Chen, Guang Yang, Xian Liu, Shaobing Zhou
Summary: The mineralized nanofiber scaffold promotes osteogenic differentiation of bone mesenchymal stem cells and stimulates macrophage polarization towards a pro-healing phenotype, enhancing bone regeneration in the alveolar bone defect repair.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Lianghao Jia, Shanshan Wu, Ruiting Yuan, Tao Xiang, Shaobing Zhou
Summary: Inspired by human muscle and skin tissues, an effective method is proposed to fabricate hydrogel sensors with antifatigue fracture performance and high sensing sensitivity for detecting human motions. The hydrogel sensors exhibit enhanced sensing sensitivity due to the microstructured surfaces and antifatigue fracture properties of cellulose nanofiber@carbon nanotube nanohybrids.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xilin Li, Jingmei Pan, Yan Li, Funeng Xu, Jianwen Hou, Guang Yang, Shaobing Zhou
Summary: In this study, a localized drug delivery system based on a hierarchical-structured fiber device was developed to precisely reprogram tumor-associated macrophages (TAMs) and combine them with immunogenic cell death (ICD), aiming to enhance the antitumor immunotherapeutic effect.
Article
Chemistry, Multidisciplinary
Yang Luo, Yingmin Li, Zhengjie Huang, Xinyang Li, Yi Wang, Jianwen Hou, Shaobing Zhou
Summary: Aberrant energy metabolism in tumors not only promotes cell proliferation but also inhibits antitumor immunity. A novel metabolic nanoregulator was developed to cut off energy supply and improve immune suppression, enabling synergistic tumor starvation-immunotherapy.
Article
Chemistry, Physical
Yao Xiao, Ling Zhang, Mengzhen Shi, Rui Tang, Zherui Jiang, Yue Song, Yuan Tian, Shaobing Zhou
Summary: Stapled peptides, when combined with DOX, show enhanced therapeutic efficacy in cancer cells due to their robust cellular permeability and therapeutic effects.
Article
Chemistry, Analytical
Jinyan Zhao, Yingping Li, Xin Chen, Dan Mu, Jingya Zhao, Shaobing Zhou
Summary: Rapid and sensitive detection of pathogenic bacteria is crucial for timely treatment of sepsis and reducing mortality. This study presents a sensitive near-infrared fluorescence identification and rapid magnetic capture method for detecting multiple bacteria in whole blood based on bioorthogonal nanoprobes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Tianyu Yin, Xinyu Zhang, Shuai Shao, Tao Xiang, Shaobing Zhou
Summary: In this study, covalently crosslinked porous cryogels with high adsorption capacity and reusability were fabricated for the removal of cationic dyes in wastewater. The cryogels exhibited excellent adsorption performance under alkaline conditions, and maintained their adsorption capacity and selective adsorption capability after regeneration.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Xudong Wen, Xiang Xiong, Guang Yang, Wenjing Xiao, Jun Hou, Tao Pan, Yonghe Hu, Shaobing Zhou
Summary: A novel core/shell structured nanoplatform has been developed for targeted delivery of catalase, doxorubicin (Dox), and resiquimod (R848) to enhance the efficacy of immunotherapy. The nanoplatform actively targets the tumor site and blocks the A2AR pathway in T regulatory (Treg) cells through in situ oxygen production and the release of Dox and R848. This leads to a decreased expression of Treg cells and improved activation of dendritic cells (DCs), resulting in a significant inhibition of tumor growth.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Zijian Shao, Tianyu Yin, Jinbo Jiang, Yang He, Tao Xiang, Shaobing Zhou
Summary: A self-adaptive multifunctional hydrogel with self-healing property and injectability has been developed for treating diabetic wounds. The hydrogel can react with high glucose and hydrogen peroxide to alleviate oxidative stress and release drugs. In animal experiments, the hydrogel accelerates angiogenesis and wound closure. This self-adaptive multifunctional hydrogel shows potential for the treatment of diabetic wounds.
BIOACTIVE MATERIALS
(2023)
Review
Engineering, Biomedical
Tao Xiang, Qianru Guo, Lianghao Jia, Tianyu Yin, Wei Huang, Xinyu Zhang, Shaobing Zhou
Summary: This review discusses the application of intelligent hydrogels with multifunctional capacities in the healing of diabetic wounds. These hydrogels can dynamically respond to the microenvironment and accelerate wound healing through various ways, including stimuli-responsiveness, injectable self-healing, shape-memory, conductive and real-time monitoring properties. Antibacterial, anti-inflammatory, immunomodulatory, antioxidant and pro-angiogenic strategies are combined with the hydrogels based on the microenvironment of diabetic wounds. This review aims to provide guidelines for fabricating hydrogels for diabetic wound healing and explore the role of intelligent hydrogels in the therapeutic processes.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Physical
Xiang Song, Lianghao Jia, Zhengen Wei, Tao Xiang, Shaobing Zhou
Summary: This paper provides an overview of the application, preparation, and role of biomimetic structures in solar evaporators with improved evaporation rate and lifetime.
JOURNAL OF MATERIALS CHEMISTRY A
(2024)
Article
Polymer Science
Tao Xiang, Jiao Wang, Lianghao Jia, Pan Wang, Shaobing Zhou
Summary: Two-way shape-memory polymers (2W-SMPs) have attracted attention for their potential applications in smart actuators, soft robotics, and artificial muscles. This work proposes a facile fabrication method for water-triggered 2W-SMPs using a one-step free radical polymerization approach, demonstrating programmable and reversible shape-memory effects.
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.
