From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease

iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates

(2020) A. H. Laperle et al.   NATURE MEDICINE

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

(2020) Anne-Laure Mahul-Mellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autonomic dysfunction in Parkinson disease and animal models

(2019) Jeanette M. Metzger et al.   CLINICAL AUTONOMIC RESEARCH

Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology

(2019) Miquel Vila et al.   Autophagy

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

Physiological changes in neurodegeneration — mechanistic insights and clinical utility

(2018) Rebekah M. Ahmed et al.   Nature Reviews Neurology

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease

(2017) L Chansel-Debordeaux et al.   GENE THERAPY

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

(2017) Sara Nolbrant et al.   Nature Protocols

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions

(2016) William T. Hendriks et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships

(2016) Laura J. Sittig et al.   NEURON

Modeling sleep alterations in Parkinson's disease: How close are we to valid translational animal models?

(2016) Karim Fifel et al.   SLEEP MEDICINE REVIEWS

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque

(2016) James B. Koprich et al.   PLoS One

Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain

(2015) W. Yang et al.   JOURNAL OF NEUROSCIENCE

Zooming in on the small: The plasticity of striatal dendritic spines inl-DOPA-Induced dyskinesia

(2015) Tim Fieblinger et al.   MOVEMENT DISORDERS

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Rodent models of impulsive–compulsive behaviors in Parkinson's disease: How far have we reached?

(2015) M. Angela Cenci et al.   NEUROBIOLOGY OF DISEASE

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

(2015) Matthieu F. Bastide et al.   PROGRESS IN NEUROBIOLOGY

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Long-term maintenance of human induced pluripotent stem cells by automated cell culture system

(2015) Shuhei Konagaya et al.   Scientific Reports

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

(2015) Mathieu Bourdenx et al.   Acta Neuropathologica Communications

Nigral 6-hydroxydopamine lesion impairs performance in a lateralised choice reaction time task—Impact of training and task parameters

(2014) Hanna S. Lindgren et al.   BEHAVIOURAL BRAIN RESEARCH

Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease

(2014) Daniela Berg et al.   MOVEMENT DISORDERS

Basic Neuroscience Research with Nonhuman Primates: A Small but Indispensable Component of Biomedical Research

(2014) Pieter R. Roelfsema et al.   NEURON

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?

(2014) Giselle Charron et al.   Frontiers in Aging Neuroscience

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

(2014) Diana F. Lázaro et al.   PLoS Genetics

Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications

(2014) M. Angela Cenci   Frontiers in Neurology

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Stem Cell Applications in Regenerative Medicine for Neurological Disorders

(2013) Shih-Ping Liu et al.   CELL TRANSPLANTATION

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Evolutionarily Novel Functional Networks in the Human Brain?

(2013) D. Mantini et al.   JOURNAL OF NEUROSCIENCE

Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease

(2013) G Drui et al.   MOLECULAR PSYCHIATRY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Parkinson's Disease in Primates: The MPTP Model

(2013) G. Porras et al.   Cold Spring Harbor Perspectives in Medicine

Animal models of the non-motor features of Parkinson's disease

(2012) Kimberly McDowell et al.   NEUROBIOLOGY OF DISEASE

Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques

(2012) Benjamin Dehay et al.   Scientific Reports

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

A tale on animal models of Parkinson's disease

(2011) Erwan Bezard et al.   MOVEMENT DISORDERS

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

(2011) Veronica Francardo et al.   NEUROBIOLOGY OF DISEASE

Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

(2010) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Flows and flaws in primary central nervous system lymphoma

(2010) Andrés J. M. Ferreri et al.   Nature Reviews Clinical Oncology

Neurovascular Congruence during Cerebral Cortical Development

(2009) Daniel Stubbs et al.   CEREBRAL CORTEX

A Stem Cell Niche for Intermediate Progenitor Cells of the Embryonic Cortex

(2009) Ashkan Javaherian et al.   CEREBRAL CORTEX

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE