Anti-Inflammatory Action and Mechanisms of Resveratrol

Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice

(2020) Yuxin Xian et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway

(2020) Tao Li et al.   MOLECULAR IMMUNOLOGY

Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets

(2020) Hao Zhang et al.   Journal of Animal Science and Biotechnology

Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke

(2020) Shan Wang et al.   EXPERIMENTAL NEUROLOGY

Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy

(2020) Danielly C. Ferraz da Costa et al.   MOLECULES

Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis

(2020) Amritpal Singh et al.   Antioxidants

The deleterious effect of stress‐induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway

(2020) Mona A. Kortam et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Resveratrol alleviates the interleukin-1β-induced chondrocytes injury through the NF-κB signaling pathway

(2020) Hong Yi et al.   Journal of Orthopaedic Surgery and Research

Polydatin attenuates Mycoplasma gallisepticum (HS strain)-induced inflammation injury via inhibiting the TLR6/ MyD88/NF-κB pathway

(2020) Mengyun Zou et al.   MICROBIAL PATHOGENESIS

Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol

(2019) Adele Chimento et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway

(2019) Chao Li et al.   BMC Complementary and Alternative Medicine

A Novel Quinolyl‐Substituted Analogue of Resveratrol Inhibits LPS‐Induced Inflammatory Responses in Microglial Cells by Blocking the NF‐κB/MAPK Signaling Pathways

(2019) Yue Hou et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers

(2019) Shaoping He et al.   POULTRY SCIENCE

Resveratrol-mediated inhibition of cyclooxygenase-2 in melanocytes suppresses melanogenesis through extracellular signal-regulated kinase 1/2 and phosphoinositide 3-kinase/Akt signalling

(2019) Seong-Hui Eo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats

(2019) Kang Cheng et al.   JOURNAL OF THERMAL BIOLOGY

Dietary polyphenols to combat the metabolic diseases via altering gut microbiota

(2019) Vemana Gowd et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

(2019) Thea Magrone et al.   Antioxidants

Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain

(2018) V. Palomera-Ávalos et al.   EXPERIMENTAL GERONTOLOGY

Protective effects of resveratrol against high ambient temperature-induced spleen dysplasia in broilers through modulating splenic redox status and apoptosis

(2018) Cheng Zhang et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-κB signaling

(2018) Mohammad Rasheduzzaman et al.   LIFE SCIENCES

Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf/J Mice

(2018) Sheikh F. Ahmad et al.   NEUROMOLECULAR MEDICINE

Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2

(2018) Xia Li et al.   OncoTargets and Therapy

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

(2018) Qingwei Meng et al.   Journal of Animal Science and Biotechnology

Resveratrol alleviates ethanol-induced neuroinflammation in vivo and in vitro: Involvement of TLR2-MyD88-NF-κB pathway

(2018) Baoning Qi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation

(2018) Daniele Maria Lopes Pinheiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol protects porcine intestinal epithelial cells from deoxynivalenol induced damage via the Nrf2 signaling pathway

(2018) Jun Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

(2018) Michał Wiciński et al.   Nutrients

Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism

(2017) Asie Sadeghi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol inhibits LPS-induced mice mastitis through attenuating the MAPK and NF-κB signaling pathway

(2017) Xu Zhang et al.   MICROBIAL PATHOGENESIS

Resveratrol attenuates hydrogen peroxide‑induced apoptosis, reactive oxygen species generation, and PSGL‑1 and VWF activation in human umbilical vein endothelial cells, potentially via MAPK signalling pathways

(2017) Zhenkai Lou et al.   Molecular Medicine Reports

Resveratrol and inflammatory bowel disease: the evidence so far

(2017) Sandra Nunes et al.   NUTRITION RESEARCH REVIEWS

Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers

(2017) C Zhang et al.   POULTRY SCIENCE

Resveratrol protects neuronal cells from isoflurane‑induced inflammation and oxidative stress‑associated death by attenuating apoptosis via Akt/p38 MAPK signaling

(2017) Weilan Hu et al.   Experimental and Therapeutic Medicine

Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade

(2017) Guangxi Wang et al.   Scientific Reports

Sirtuin 1 regulates matrix metalloproteinase-13 expression induced by Porphyromonas endodontalis lipopolysaccharide via targeting nuclear factor–κB in osteoblasts

(2017) Liu Qu et al.   Journal of Oral Microbiology

Cellular and molecular regulation of innate inflammatory responses

(2016) Juan Liu et al.   Cellular & Molecular Immunology

Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways

(2016) Lei Cao et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol

(2016) Maria Pia Fuggetta et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Anti-inflammatory effect of resveratrol through the suppression of NF- B and JAK/STAT signaling pathways

(2015) C. Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Resveratrol attenuates the progress of liver fibrosis via the Akt/nuclear factor-κB pathways

(2015) HUI ZHANG et al.   Molecular Medicine Reports

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

(2015) Dinesh Babu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Tumor Suppressor Death-Associated Protein Kinase Targets to TCR-Stimulated NF- B Activation

(2014) Y.-T. Chuang et al.   JOURNAL OF IMMUNOLOGY

Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens

(2014) L. L. Liu et al.   POULTRY SCIENCE

Regulation of inflammation by DAPK

(2013) Ming-Zong Lai et al.   APOPTOSIS

The role of oxidative stress during inflammatory processes

(2013) Jérôme Lugrin et al.   BIOLOGICAL CHEMISTRY

Resveratrol Attenuates Oxidative Stress Induced by Balloon Injury in the Rat Carotid Artery Through Actions on the ERK1/2 and NF-Kappa B Pathway

(2013) Jing Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Resveratrol induces autophagy through death-associated protein kinase 1 (DAPK1) in human dermal fibroblasts under normal culture conditions

(2013) Min Sik Choi et al.   EXPERIMENTAL DERMATOLOGY

Plumbagin inhibits LPS-induced inflammation through the inactivation of the nuclear factor-kappa B and mitogen activated protein kinase signaling pathways in RAW 264.7 cells

(2013) Tingyu Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

(2013) Yue Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells

(2013) Ruey-Shyang Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-κB activation in Caco-2 and SW480 human colon cancer cells

(2012) Maria Antonietta Panaro et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol protects H9c2 embryonic rat heart derived cells from oxidative stress by inducing autophagy: role of p38 mitogen-activated protein kinase

(2012) Xiao Cui Lv et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway

(2012) CUI ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway

(2012) Tae-Wuk Kim et al.   NATURE

Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia

(2012) Fabrício Simão et al.   NEUROCHEMISTRY INTERNATIONAL

Resveratrol Inhibits Inflammatory Responses via the Mammalian Target of Rapamycin Signaling Pathway in Cultured LPS-Stimulated Microglial Cells

(2012) Lian-Mei Zhong et al.   PLoS One

Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance

(2012) B. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells

(2011) Mehdi Shakibaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat stress-induced hepatotoxicity and its prevention by resveratrol in rats

(2011) Asima Das   TOXICOLOGY MECHANISMS AND METHODS

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

(2010) Barbara Calamini et al.   BIOCHEMICAL JOURNAL

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Effect of Resveratrol on Gliotransmitter Levels and p38 Activities in Cultured Astrocytes

(2010) Hao Zhou et al.   NEUROCHEMICAL RESEARCH

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol: One molecule, many targets

(2008) Luciano Pirola et al.   IUBMB LIFE

Resveratrol directly targets COX-2 to inhibit carcinogenesis

(2008) Tatyana A. Zykova et al.   MOLECULAR CARCINOGENESIS

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Cyclo-oxygenase-2 Plays a Critical Role in UV-induced Skin Carcinogenesis

(2008) Joyce E. Rundhaug et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?

(2007) Philipp Saiko et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH