Nanomedicine Reformulation of Chloroquine and Hydroxychloroquine

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Magnetic iron oxide nanoparticles for imaging, targeting and treatment of primary and metastatic tumors of the brain

(2020) Liron L. Israel et al.   JOURNAL OF CONTROLLED RELEASE

Prophylactic (hydroxy)chloroquine in COVID-19: Potential relevance for cardiac arrhythmia risk

(2020) Joost A. Offerhaus et al.   HEART RHYTHM

Retraction—Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

(2020) Mandeep R Mehra et al.   LANCET

Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy

(2020) Aniket Wahane et al.   MOLECULES

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

(2020) Markus Hoffmann et al.   NATURE

Liposomes for enhanced cellular uptake of anticancer agents

(2020) Gamal M. El Maghraby et al.   Current Drug Delivery

A reanalysis of nanoparticle tumor delivery using classical pharmacokinetic metrics

(2020) Lauren S. L. Price et al.   Science Advances

COVID-19 Vaccine Frontrunners and Their Nanotechnology Design

(2020) Young Hun Chung et al.   ACS Nano

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Anticancer autophagy inhibitors attract ‘resurgent’ interest

(2019) Elie Dolgin   NATURE REVIEWS DRUG DISCOVERY

Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy

(2019) Qianhua Feng et al.   ACS Applied Materials & Interfaces

Synergistic cytotoxicity and co-autophagy inhibition in pancreatic tumor cells and cancer-associated fibroblasts by dual functional peptide-modified liposomes

(2019) Xiaoxiao Chen et al.   Acta Biomaterialia

Hydroxychloroquine in dermatology: New perspectives on an old drug

(2019) Christopher Y Chew et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Manipulation of Mitophagy by “All-in-One” nanosensitizer augments sonodynamic glioma therapy

(2019) Fei Qu et al.   Autophagy

Aggregable Nanoparticles-Enabled Chemotherapy and Autophagy Inhibition Combined with Anti-PD-L1 Antibody for Improved Glioma Treatment

(2019) Shaobo Ruan et al.   NANO LETTERS

A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy

(2019) Wesley L. Fotoran et al.   Nanomedicine-Nanotechnology Biology and Medicine

Pharmacokinetics of lipid-drug conjugates loaded into liposomes

(2018) Rea D. Signorell et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Enhanced glioma therapy by synergistic inhibition of autophagy and tyrosine kinase activity

(2018) Xuhui Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Potentiating bacterial cancer therapy using hydroxychloroquine liposomes

(2018) Ying Wang et al.   JOURNAL OF CONTROLLED RELEASE

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Nanovaccine Incorporated with Hydroxychloroquine Enhances Antigen Cross-Presentation and Promotes Antitumor Immune Responses

(2018) Jiale Liu et al.   ACS Applied Materials & Interfaces

Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas

(2018) Hongmei Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dual receptor recognizing liposomes containing paclitaxel and hydroxychloroquine for primary and metastatic melanoma treatment via autophagy-dependent and independent pathways

(2018) Sheng Yin et al.   JOURNAL OF CONTROLLED RELEASE

Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease

(2018) Shrey Kanvinde et al.   Acta Biomaterialia

Encapsulation of chloroquine and doxorubicin by MPEG-PLA to enhance anticancer effects by lysosomes inhibition in ovarian cancer

(2018) Ming Shao et al.   International Journal of Nanomedicine

Polymer–drug conjugate therapeutics: advances, insights and prospects

(2018) Iriny Ekladious et al.   NATURE REVIEWS DRUG DISCOVERY

Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs

(2018) Elisabet Martí Coma-Cros et al.   Pharmaceutics

Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box–Behnken design and its antimalarial efficacy

(2017) Uday Krishna Baruah et al.   JOURNAL OF DRUG TARGETING

Investigation and intervention of autophagy to guide cancer treatment with nanogels

(2017) Xudong Zhang et al.   Nanoscale

Cholesterol-modified Hydroxychloroquine-loaded Nanocarriers in Bleomycin-induced Pulmonary Fibrosis

(2017) Li Liu et al.   Scientific Reports

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

(2016) Yang Wang et al.   Autophagy

Research progress of hydroxychloroquine and autophagy inhibitors on cancer

(2016) Ting-Ting Shi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications

(2016) Juan Li et al.   CHEMICAL SOCIETY REVIEWS

Fabrication and efficacy evaluation of chloroquine nanoparticles in CFA-induced arthritic rats using TNF-α ELISA

(2016) Mangesh R. Bhalekar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Coencapsulation of alendronate and doxorubicin in pegylated liposomes: a novel formulation for chemoimmunotherapy of cancer

(2016) Hilary Shmeeda et al.   JOURNAL OF DRUG TARGETING

Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition

(2016) Menghua Gao et al.   JOURNAL OF LIPOSOME RESEARCH

Rapid Onset of Retinal Toxicity From High-Dose Hydroxychloroquine Given for Cancer Therapy

(2015) Loh-Shan B. Leung et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A novel antitumour strategy using bidirectional autophagic vesicles accumulation via initiative induction and the terminal restraint of autophagic flux

(2015) Yang Wang et al.   JOURNAL OF CONTROLLED RELEASE

Immunoliposome-mediated drug delivery to Plasmodium -infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy

(2015) Ernest Moles et al.   JOURNAL OF CONTROLLED RELEASE

Facile Construction of Chloroquine Containing PLGA-Based pDNA Delivery System for Efficient Tumor and Pancreatitis Targeting in Vitro and in Vivo

(2015) Chengli Yang et al.   MOLECULAR PHARMACEUTICS

In vitro experiments showing enhanced release of doxorubicin from Doxil® in the presence of ammonia may explain drug release at tumor site

(2015) Lisa Silverman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

A prospective strategy to restore the tissue damage in malaria infection: Approach with chitosan-trypolyphosphate conjugated nanochloroquine in Swiss mice

(2014) Satyajit Tripathy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium

(2014) Patricia Urbán et al.   JOURNAL OF CONTROLLED RELEASE

The Role of Payload Hydrophobicity in Nanotherapeutic Pharmacokinetics

(2014) Povilas Norvaisas et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection

(2013) Satyajit Tripathy et al.   ACTA TROPICA

Hydroxychloroquine niosomes: A new trend in topical management of oral lichen planus

(2013) Ehab R. Bendas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Correction: New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles

(2013) Nelly Mezzaroba et al.   PLoS One

Synthesis, characterization of chitosan–tripolyphosphate conjugated chloroquine nanoparticle and its in vivo anti-malarial efficacy against rodent parasite: A dose and duration dependent approach

(2012) Satyajit Tripathy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine

(2011) Michel Michaelides   ARCHIVES OF OPHTHALMOLOGY

Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine

(2010) Didier Astruc et al.   CHEMICAL REVIEWS

Translational considerations for cancer nanomedicine

(2010) Stephan T. Stern et al.   JOURNAL OF CONTROLLED RELEASE