Synthesis of the Hexahydropyrrolo-[3,2-c]-quinoline Core Structure and Strategies for Further Elaboration to Martinelline, Martinellic Acid, Incargranine B, and Seneciobipyrrolidine

Multiple Catalytic C-H Bond Functionalization for Natural Product Synthesis

(2020) Olivier Baudoin   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in the Total Synthesis of Natural Products Containing Eight-Membered Carbocycles (2009–2019)

(2020) Ya-Jian Hu et al.   CHEMICAL REVIEWS

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Helquats as Promoters of the Povarov Reaction: Synthesis of 1,2,3,4‐Tetrahydroquinoline Scaffolds Catalyzed by Helicene‐Viologen Hybrids

(2020) Paul E. Reyes‐Gutiérrez et al.   ChemPlusChem

New Twists in Nazarov Cyclization Chemistry

(2020) Alison J. Frontier et al.   ACCOUNTS OF CHEMICAL RESEARCH

Halogen Bond‐Catalyzed Povarov Reactions

(2020) Xuelei Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances of Applying Boron‐Reagents in Asymmetric Total Syntheses of Natural Products and Bio‐Active Molecules

(2020) Subarna Jyoti Kalita et al.   ADVANCED SYNTHESIS & CATALYSIS

Advances in N-Heterocyclic Carbene Catalysis for Natural Product Synthesis

(2020) Yonglei Que et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Daphniphyllum Alkaloids: From Bicycles to Diversified Caged Structures

(2020) Lian-Dong Guo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Photoredox Mediated Acceptorless Dehydrogenative Coupling of Saturated N-Heterocycles

(2019) Zongbin Jia et al.   ACS Catalysis

Construction of a (3aR,4R,9bR)-Hexahydropyrroloquinoline by Stereoselective Hydrogen-Mediated Domino Cyclization

(2019) Masatoshi Yamada et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9

(2019) Basudeb Maji et al.   CELL

Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged Heterocycles

(2019) M. Klika Škopić et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Arylation of α-Amino C(sp3 )-H Bonds by Convergent Paired Electrolysis

(2019) Yueyue Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual C(sp3 )−H Bond Functionalization of N-Heterocycles through Sequential Visible-Light Photocatalyzed Dehydrogenation/[2+2] Cycloaddition Reactions

(2018) Guo-Qiang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Csp3–H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines

(2018) Lou Shi et al.   CHEMICAL COMMUNICATIONS

Modular Synthesis of Dipyrroloquinolines: A Combined Synthetic and Mechanistic Study

(2018) Johannes Appun et al.   JOURNAL OF ORGANIC CHEMISTRY

The Divergent Cascade Reactions of Arylalkynols with Homopropargylic Amines or Electron-Deficient Olefins: Access to the Spiro-Isobenzofuran-b-pyrroloquinolines or Bridged-Isobenzofuran Polycycles

(2018) Lun Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of α-Formylated N-Heterocycles and Their 1,1-Diacetates from Inactivated Cyclic Amines Involving an Oxidative Ring Contraction

(2018) Fang Wang et al.   ORGANIC LETTERS

The Catalyst-Controlled Divergent Cascade Reactions of Homo-Propargylic Amines and Nitrones: Synthesis of Pyrrolo-Isoxazolidines and γ-Lactams

(2018) Yuanfang Kong et al.   ADVANCED SYNTHESIS & CATALYSIS

Carbene-Catalyzed Enantioselective Addition of Benzylic Carbon to Unsaturated Acyl Azolium for Rapid Synthesis of Pyrrolo[3,2-c]quinolines

(2018) Jilan Wang et al.   ACS Catalysis

Organocatalytic C(sp3)–H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]azepines

(2017) Shuai-Shuai Li et al.   ORGANIC LETTERS

Molecular Connectivity Predefines Polypharmacology: Aliphatic Rings, Chirality, and sp3 Centers Enhance Target Selectivity

(2017) Stefania Monteleone et al.   Frontiers in Pharmacology

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile

(2017) Jeremy R. Duvall et al.   ACS Infectious Diseases

Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis

(2016) Gareth A. Prosser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Tumor Necrosis Factor-α and Interleukin-1β Production in Lipopolysaccharide-Stimulated Monocytes by Methanolic Extract of Elephantopus scaber Linn and Identification of Bioactive Components

(2016) Anu P. Abhimannue et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Intramolecular Cycloaddition of Azomethine Ylides Activated by Aromatic Rings: Scope and Limitations

(2016) Hongxiang Xie et al.   Chemistry of Heterocyclic Compounds

Domino Staudinger/aza-Wittig/Mannich Reaction: An Approach to Diversity of Di- and Tetrahydropyrrole Scaffolds

(2016) Anna S. Pavlova et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper(II) Trifluoromethanesulfonate Catalyzed Hydroamination Cyclization-Dimerization Cascade Reaction of Homopropargylic Amines for the Construction of Complex Fused Nitrogen-Containing Tetracycles

(2016) Lingyan Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The cyclopropylimine rearrangement/Povarov reaction cascade for the assembly of pyrrolo[3,2-c]quinoline derivatives

(2016) Jinhui Cai et al.   GREEN CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Diastereoselective Intramolecular [3 + 2]-Annulation of Donor–Acceptor Cyclopropane with Imine-Assembling Hexahydropyrrolo[3,2-c]quinolinone Scaffolds

(2016) Jun-An Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Multi-constituent identification in Australian cane toad skin extracts using high-performance liquid chromatography high-resolution tandem mass spectrometry

(2016) Abu Hasanat Md. Zulfiker et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Copper-Catalyzed Cascade Reaction via Intramolecular Hydroamination Cyclization of Homopropargylic Amines and Intermolecular Povarov Reaction with Imines

(2016) Hongkai Wang et al.   ORGANIC LETTERS

Synthesis of β -prolinols via [3+2] cycloaddition and one-pot programmed reduction: Valuable building blocks for polyheterocycles

(2016) Jundong Li et al.   TETRAHEDRON LETTERS

Counteranion-Controlled Unprecedented Diastereo- and Enantioselective Tandem Formal Povarov Reaction for Construction of Bioactive Octahydro-Dipyrroloquinolines

(2016) Xiao-Long Yu et al.   ACS Catalysis

Gold-catalyzed tandem synthesis of bioactive spiro-dipyrroloquinolines and its application in the one-step synthesis of incargranine B aglycone and seneciobipyrrolidine (I)

(2016) Can-Liang Ma et al.   Organic Chemistry Frontiers

Catalytic Enantioselective Synthesis of the Partially Reduced Tricyclic Pyrrolo[3,2-c]quinoline Core Structure of theMartinellaAlkaloids

(2016) Emil Lindbäck et al.   ChemistrySelect

Enantioselective Total Synthesis of (−)-Martinellic Acid

(2015) Mukesh Pappoppula et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sodium Salts of Anionic Chiral Cobalt(III) Complexes as Catalysts of the Enantioselective Povarov Reaction

(2015) Jie Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis

(2015) Sae Woong Park et al.   CHEMISTRY & BIOLOGY

Ring Opening of Donor-Acceptor Cyclopropanes with the Azide Ion: A Tool for Construction of N-Heterocycles

(2015) Konstantin L. Ivanov et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly regio- and diastereo-selective synthesis of novel tri- and tetra-cyclic perhydroquinoline architectures via an intramolecular [3 + 2] cycloaddition reaction

(2015) M. Bakthadoss et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Lewis acid-catalyzed reaction between tertiary enamides and imines of salicylaldehydes: expedient synthesis of novel 4-chromanamine derivatives

(2015) Ling He et al.   TETRAHEDRON

Three New Alkaloids from Senecio scandens

(2014) Daopeng Tan et al.   CHEMISTRY OF NATURAL COMPOUNDS

Modular, Flexible, and Stereoselective Synthesis of Pyrroloquinolines: Rapid Assembly of Complex Heterocyclic Scaffolds

(2014) Michael Boomhoff et al.   ORGANIC LETTERS

Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach

(2014) Chang Min et al.   ORGANIC LETTERS

Highly Stereoselective Synthesis of Functionalized Pyrrolo[3,2-c]quinolines via N-Heterocyclic Carbene Catalyzed Cascade Sequence

(2014) Yu-Jie Yang et al.   ORGANIC LETTERS

Silver-catalysed direct amination of unactivated C–H bonds of functionalized molecules

(2014) Mingyu Yang et al.   Nature Communications

Total Synthesis and Structural Revision of the Alkaloid Incargranine B

(2013) Patrick D. Brown et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Asymmetric Intermolecular Cyclization

(2013) Jian Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism of the Tissue-Specific Action of the Selective Androgen Receptor Modulator S-101479

(2013) Kazuyuki Furuya et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gold catalyzed stereoselective tandem hydroamination–formal aza-Diels–Alder reaction of propargylic amino esters

(2013) Santos Fustero et al.   CHEMICAL COMMUNICATIONS

Senecio scandens Buch.-Ham.: A review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity

(2013) Dongmei Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

FeCl3-Catalyzed Cascade Cyclization in One Pot: Synthesis of Ring-Fused Tetrahydroquinoline Derivatives from Arylamines and N-Substituted Lactams

(2013) Manman Sun et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of highly functionalized pyrrolidines as tunable templates for the direct access to (±)-coerulescine and the tricyclic core of martinellines

(2013) Ronan Le Goff et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Synthesis of (−)-Martinellic Acid

(2013) Stephen G. Davies et al.   ORGANIC LETTERS

Catalytic Asymmetric Aza-Diels–Alder Reactions: The Povarov Cycloaddition Reaction

(2013) Mariafrancesca Fochi et al.   SYNTHESIS-STUTTGART

A diastereodivergent strategy for the asymmetric syntheses of (−)-martinellic acid and (−)-4-epi-martinellic acid

(2013) Stephen G. Davies et al.   TETRAHEDRON

Reagent-free synthesis of 2,3,4-polysubstituted tetrahydroquinolines: application to the formal synthesis of (±)-martinellic acid and martinelline

(2013) Zhouting Rong et al.   TETRAHEDRON LETTERS

A Catalytic Multicomponent Approach for the Stereoselective Synthesis ofcis-4,5-Disubstituted Pyrrolidinones and Tetrahydro-3H-pyrrolo[3,2-c]quinolines

(2012) Sudipta Roy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Novel Non-steroidal Selective Androgen Receptor Modulator S-101479 Has Additive Effects with Bisphosphonate, Selective Estrogen Receptor Modulator, and Parathyroid Hormone on the Bones of Osteoporotic Female Rats

(2012) Kazuyuki Furuya et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Cyclic Enethioureas as Dienophiles: Stereocontrolled Access to Enantioenriched Hexahydropyrroloquinolines

(2012) Guillaume Dagousset et al.   CHEMISTRY-A EUROPEAN JOURNAL

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK2 Antagonists

(2012) Takahiro Tanaka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effects of TAK-480, a Novel Tachykinin NK2^|^ndash;Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid^|^ndash;Induced Defecation in Guinea Pigs

(2012) Takahiro Tanaka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Construction of Nitrogen-Fused Tetrahydroquinolines via a Domino Reaction

(2012) Nicolas Gigant et al.   ORGANIC LETTERS

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library

(2012) Baudouin Gerard et al.   ACS Combinatorial Science

Asymmetric catalytic hydrogenation for large scale preparation of optically active 2-(N-benzoylamino)cyclohexanecarboxylic acid derivatives

(2012) Takeshi Kajiwara et al.   Catalysis Science & Technology

One-Step Construction of Tetrahydro-5H-indolo[3,2-c]quinolines from Benzyl Azides and Indoles via a Cascade Reaction Sequence

(2011) Zengqiang Song et al.   ORGANIC LETTERS

A Unique Indolo-[1,7]naphthyridine Alkaloid from Incarvillea mairei var. grandiflora (Wehrh.) Grierson

(2010) Yun-Heng Shen et al.   HELVETICA CHIMICA ACTA

Efficient Entry into 2-Substituted Tetrahydroquinoline Systems through Alkylative Ring Expansion: Stereoselective Formal Synthesis of (±)-Martinellic Acid

(2010) Masafumi Ueda et al.   JOURNAL OF ORGANIC CHEMISTRY

A New Palladium Precatalyst Allows for the Fast Suzuki−Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic Acids

(2010) Tom Kinzel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Cooperative Catalysis of Strong Bronsted Acid-Promoted Reactions Using Chiral Ureas

(2010) H. Xu et al.   SCIENCE

Natural product scaffolds as leads to drugs

(2009) David J Newman et al.   Future Medicinal Chemistry

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic Resolution of 2,3-Dihydro-2-substituted 4-Quinolones by Palladium-Catalyzed Asymmetric Allylic Alkylation

(2009) Bai-Lin Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): Pyridodiazepine amines

(2008) Bolin Geng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthetic Studies Toward the Martinella Alkaloids

(2008) Carl Lovely et al.   CURRENT ORGANIC CHEMISTRY

Total Synthesis of (−)-Martinellic Acid via Radical Addition−Cyclization−Elimination Reaction

(2008) Atsushi Shirai et al.   JOURNAL OF ORGANIC CHEMISTRY

New and Expeditious Tandem Sequence Aza-Michael/Intramolecular Nucleophilic Substitution Route to Substituted γ-Lactams: Synthesis of the Tricyclic Core of (±)-Martinellines

(2008) Sébastien Comesse et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective synthesis of martinelline chiral core and its diastereomer using asymmetric tandem Michael–aldol reaction

(2008) Yayoi Yoshitomi et al.   TETRAHEDRON

Recent synthetic developments in a powerful imino Diels–Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids

(2008) Vladimir V. Kouznetsov   TETRAHEDRON