Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

Store-operated calcium entry in thrombosis and thrombo-inflammation

(2018) Elmina Mammadova-Bach et al.   CELL CALCIUM

Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

(2018) Wataru Shihoya et al.   Nature Communications

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin

(2016) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site

(2016) Ganesh Kadamur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Gq signalling pathway inhibits brown and beige adipose tissue

(2016) Katarina Klepac et al.   Nature Communications

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/oand Its Downstream Effector Molecules

(2015) Katharina Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Measurement of Inositol 1,4,5-Trisphosphate in Living Cells Using an Improved Set of Resonance Energy Transfer-Based Biosensors

(2015) Gergő Gulyás et al.   PLoS One

Membrane-induced Allosteric Control of Phospholipase C-β Isozymes

(2014) Thomas H. Charpentier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297

(2014) N. Wydeven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Phospholipase C β3 Autoinhibition

(2014) Angeline M. Lyon et al.   STRUCTURE

Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain

(2013) Angeline M Lyon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms

(2013) Anke C. Schiedel et al.   Purinergic Signalling

Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist

(2013) S. Hennen et al.   Science Signaling

New insights into the therapeutic potential of Girk channels

(2013) Rafael Luján et al.   TRENDS IN NEUROSCIENCES

Mammalian Phospholipase C

(2012) Ganesh Kadamur et al.   Annual Review of Physiology

P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells

(2012) Christian Gachet   Purinergic Signalling

D-type prostanoid receptor enhances the signaling of chemoattractant receptor–homologous molecule expressed on TH2 cells

(2011) Miriam Sedej et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Dynamic Model of Membrane-Bound Phospholipase C 2 Activation by G   Subunits

(2011) D. S. Han et al.   MOLECULAR PHARMACOLOGY

Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

(2011) Ralf Schröder et al.   Nature Protocols

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

(2011) Angeline M Lyon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synergistic Activation of Phospholipase C-β3 by Gαq and Gβγ Describes a Simple Two-State Coincidence Detector

(2010) Finly Philip et al.   CURRENT BIOLOGY

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

(2010) Aurelie Gresset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Ca2+Responses by Gαi- and Gαq-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβγ and Gαq

(2010) Robert A. Rebres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Kinetic Scaffolding Mediated by a Phospholipase C-  and Gq Signaling Complex

(2010) G. L. Waldo et al.   SCIENCE

IP3 Receptors: Toward Understanding Their Activation

(2010) C. W. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration

(2009) Marie-Laure Rives et al.   EMBO JOURNAL

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils

(2009) Zhifang Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer

(2009) M. W. Nasser et al.   JOURNAL OF IMMUNOLOGY

The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαiand Downstream Signaling Cascade Activation

(2008) Ralf Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL