HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation

The arms race between bacteria and their phage foes

(2020) Hannah G. Hampton et al.   NATURE

It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly

(2020) Monica C. Pillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR–Cas immunity

(2020) Kawanda Foster et al.   NUCLEIC ACIDS RESEARCH

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

(2020) Carmela Garcia-Doval et al.   Nature Communications

The Variety in the Common Theme of Translation Inhibition by Type II Toxin–Antitoxin Systems

(2020) Dukas Jurėnas et al.   Frontiers in Genetics

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

(2020) Anna Lopatina et al.   Annual Review of Virology

Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism

(2020) Xia Yu et al.   Communications Biology

Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system

(2020) Jianyun Yao et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex

(2019) Monica C. Pillon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

(2019) Rafael Molina et al.   Nature Communications

Structure–function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN–MNT toxin–antitoxin system

(2018) Xuanyan Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

(2018) Alexander Harms et al.   MOLECULAR CELL

Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis

(2018) Sergey A. Shmakov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

(2018) Cheng Zhang et al.   CELL

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

(2018) Anju Sreelatha et al.   CELL

A Hard Day’s Night: Cyanobacteria in Diel Cycles

(2018) David G. Welkie et al.   TRENDS IN MICROBIOLOGY

Endoribonuclease type II toxin–antitoxin systems: functional or selfish?

(2017) Bhaskar Chandra Mohan Ramisetty et al.   MICROBIOLOGY-SGM

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail

(2017) Wenyuan Han et al.   NUCLEIC ACIDS RESEARCH

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

tRNA-targeting ribonucleases: molecular mechanisms and insights into their physiological roles

(2016) Tetsuhiro Ogawa   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Repairing tRNA termini: News from the 3' end

(2016) Christiane Rammelt et al.   RNA Biology

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

(2016) Ole Niewoehner et al.   RNA

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

(2015) Alexander Harms et al.   Cell Reports

Identification and characterization of a HEPN-MNT family type II toxin-antitoxin inShewanella oneidensis

(2015) Jianyun Yao et al.   Microbial Biotechnology

An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3

(2014) Jason M. Schifano et al.   Nature Communications

Toxin-Antitoxin Systems as Multilevel Interaction Systems

(2014) Nathalie Goeders et al.   Toxins

Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing

(2013) Vivek Anantharaman et al.   Biology Direct

In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus

(2013) Tomas Sinkunas et al.   EMBO JOURNAL

Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning

(2013) Hila Sberro et al.   MOLECULAR CELL

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

(2012) Kira S Makarova et al.   Biology Direct

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

(2011) Yunhao Tan et al.   NATURE

Phage T4-induced dTTP accretion bolsters a tRNase-based host defense

(2011) Daniel Klaiman et al.   VIROLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The MORPHEUS protein crystallization screen

(2009) Fabrice Gorrec   JOURNAL OF APPLIED CRYSTALLOGRAPHY