Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 156, Issue -, Pages 23-39Publisher
ELSEVIER
DOI: 10.1016/j.addr.2020.05.005
Keywords
Nanoparticles; Hybrid nanostructured materials; Drug delivery; Tumor microenvironment; Combination therapy
Categories
Funding
- Carolina Center for Cancer Nanotechnology Excellence, United States (NIH) [CA198999]
- Talents Cultivation Program of Jilin University
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Cancer is one of the most severe disease burdens in modern times, with an estimated increase in the number of patients diagnosed globally from 18.1 million in 2018 to 23.6 million in 2030. Despite a significant progress achieved by conventional therapies, they have limitations and are still far from ideal. Therefore, safe, effective andwidely-applicable treatments are urgently needed. Over the past decades, the development of novel delivery approaches based on membrane-core (MC) nanostructures for transporting chemotherapeutics, nucleic acids and immunomodulators has significantly improved anticancer efficacy and reduced side effects. In this review, the formulation strategies based on MC nanostructures for delivery of anticancer drug are described, and recent advances in the application of MC nanoformulations to overcome the delivery hurdles for clinical translation are discussed. (C) 2020 Elsevier B.V. All rights reserved.
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