Estrogen Receptor on the move: Cistromic plasticity and its implications in breast cancer

ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer

(2020) Guotai Xu et al.   NATURE GENETICS

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

(2020) Sankari Nagarajan et al.   NATURE GENETICS

ELF5 modulates the estrogen receptor cistrome in breast cancer

(2020) Catherine L. Piggin et al.   PLoS Genetics

Overcoming Endocrine Resistance in Breast Cancer

(2020) Ariella B. Hanker et al.   CANCER CELL

The NFκB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

(2020) Irida Kastrati et al.   MOLECULAR CANCER RESEARCH

Cancer-specific mutation of GATA3 disrupts the transcriptional regulatory network governed by Estrogen Receptor alpha, FOXA1 and GATA3

(2020) Motoki Takaku et al.   NUCLEIC ACIDS RESEARCH

IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

(2020) Rasmus Siersbæk et al.   CANCER CELL

Prostate cancer reactivates developmental epigenomic programs during metastatic progression

(2020) Mark M. Pomerantz et al.   NATURE GENETICS

Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer

(2020) Yusheng Zhang et al.   Science Advances

Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer

(2020) Shuai Gao et al.   NATURE GENETICS

Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells

(2019) Giovanni Nassa et al.   Science Advances

Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling

(2019) Silvia-E. Glont et al.   Cell Reports

Estrogen receptor signaling is reprogrammed during breast tumorigenesis

(2019) David Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer

(2019) Ho Lam Chan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility

(2019) Jane Guan et al.   CELL

The NF-KB pathway and endocrine therapy resistance in breast cancer

(2019) Phungern Khongthong et al.   ENDOCRINE-RELATED CANCER

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice

(2019) Lisette M. Cornelissen et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Meta-analysis of Chromatin Programming by Steroid Receptors

(2019) Ville Paakinaho et al.   Cell Reports

Advances in Endocrine-Based Therapies for Estrogen Receptor-Positive Metastatic Breast Cancer

(2019) Vassilis Aggelis et al.   DRUGS

IGF‐1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER‐positive breast cancer

(2019) Dinja T. Kruger et al.   INTERNATIONAL JOURNAL OF CANCER

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations

(2018) Rinath Jeselsohn et al.   CANCER CELL

FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome

(2018) Willemijne Schrijver et al.   Molecular Oncology

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

c-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancer

(2018) Huan He et al.   ONCOGENE

Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

(2018) Tesa M. Severson et al.   Nature Communications

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

(2018) Pedram Razavi et al.   CANCER CELL

Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer

(2018) Rasmus Siersbæk et al.   GENES & DEVELOPMENT

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

(2018) Ho Lam Chan et al.   Nature Communications

Maturing of the nuclear receptor family

(2017) Mitchell A. Lazar   JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program

(2017) Feng Yang et al.   MOLECULAR CELL

Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells

(2017) Joshua D. Stender et al.   MOLECULAR CELL

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

(2017) Eneda Toska et al.   SCIENCE

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

(2017) Lesley-Ann Martin et al.   Nature Communications

Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling

(2017) Hari Singhal et al.   Oncotarget

Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers

(2017) Julia B. Carleton et al.   Cell Systems

Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

(2016) Erin E. Swinstead et al.   CELL

Cooperative Dynamics of AR and ER Activity in Breast Cancer

(2016) N. C. D'Amato et al.   MOLECULAR CANCER RESEARCH

GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome

(2016) D. C. West et al.   MOLECULAR CANCER RESEARCH

The Estrogen Receptor α-Cistrome Beyond Breast Cancer

(2016) Marjolein Droog et al.   MOLECULAR ENDOCRINOLOGY

Genome-wide mapping of autonomous promoter activity in human cells

(2016) Joris van Arensbergen et al.   NATURE BIOTECHNOLOGY

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9

(2016) Gozde Korkmaz et al.   NATURE BIOTECHNOLOGY

Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer

(2016) A Harrod et al.   ONCOGENE

ActivatingESR1Mutations Differentially Affect the Efficacy of ER Antagonists

(2016) Weiyi Toy et al.   Cancer Discovery

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation

(2016) Tesa M. Severson et al.   Oncotarget

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer

(2016) H. Singhal et al.   Science Advances

Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer

(2015) Rezvan Abduljabbar et al.   BREAST CANCER RESEARCH AND TREATMENT

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

Androgen receptor profiling predicts prostate cancer outcome

(2015) Suzan Stelloo et al.   EMBO Molecular Medicine

TNFα Signaling Exposes Latent Estrogen Receptor Binding Sites to Alter the Breast Cancer Cell Transcriptome

(2015) Hector L. Franco et al.   MOLECULAR CELL

Progesterone receptor modulates ERα action in breast cancer

(2015) Hisham Mohammed et al.   NATURE

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells

(2015) David Gallego-Ortega et al.   PLOS BIOLOGY

USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen

(2014) H. M. Oosterkamp et al.   CANCER RESEARCH

PI3K/AKT/mTOR pathway activation in primary and corresponding metastatic breast tumors after adjuvant endocrine therapy

(2014) Karin Beelen et al.   INTERNATIONAL JOURNAL OF CANCER

D538G Mutation in Estrogen Receptor- : A Novel Mechanism for Acquired Endocrine Resistance in Breast Cancer

(2013) K. Merenbakh-Lamin et al.   CANCER RESEARCH

Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer

(2013) M. P. H. M. Jansen et al.   CANCER RESEARCH

Reprogramming the Chromatin Landscape: Interplay of the Estrogen and Glucocorticoid Receptors at the Genomic Level

(2013) T. B. Miranda et al.   CANCER RESEARCH

Interaction of Glucocorticoid Receptor (GR) with Estrogen Receptor (ER) α and Activator Protein 1 (AP1) in Dexamethasone-mediated Interference of ERα Activity

(2013) Sudipan Karmakar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity

(2013) J. Druker et al.   MOLECULAR AND CELLULAR BIOLOGY

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

(2013) Weiyi Toy et al.   NATURE GENETICS

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

(2013) Dan R Robinson et al.   NATURE GENETICS

SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor

(2013) Ville Paakinaho et al.   NUCLEIC ACIDS RESEARCH

Interaction of 14-3-3 proteins with the Estrogen Receptor Alpha F domain provides a drug target interface

(2013) I. J. De Vries-van Leeuwen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seq

(2013) C. D. Arnold et al.   SCIENCE

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

(2013) Hisham Mohammed et al.   Cell Reports

Progesterone receptor loss identifies Luminal B breast cancer subgroups at higher risk of relapse

(2012) G. Cancello et al.   ANNALS OF ONCOLOGY

Higher expression of androgen receptor is a significant predictor for better endocrine-responsiveness in estrogen receptor-positive breast cancers

(2012) Seho Park et al.   BREAST CANCER RESEARCH AND TREATMENT

GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

(2012) V. Theodorou et al.   GENOME RESEARCH

Mesenchymal stem cell-derived interleukin-6 and vascular endothelial growth factor promote breast cancer cell migration

(2012) Antonella De Luca et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Minireview: Inflammation: An Instigator of More Aggressive Estrogen Receptor (ER) Positive Breast Cancers

(2012) Sarah C. Baumgarten et al.   MOLECULAR ENDOCRINOLOGY

Research Resource: Interplay between the Genomic and Transcriptional Networks of Androgen Receptor and Estrogen Receptor α in Luminal Breast Cancer Cells

(2012) Eleanor F. Need et al.   MOLECULAR ENDOCRINOLOGY

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

PKA phosphorylation redirects ERα to promoters of a unique gene set to induce tamoxifen resistance

(2012) R de Leeuw et al.   ONCOGENE

ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

(2012) Maria Kalyuga et al.   PLOS BIOLOGY

Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

(2012) Geeta N. Eick et al.   PLoS Genetics

Androgen Receptor Expression and Breast Cancer Survival in Postmenopausal Women

(2011) R. Hu et al.   CLINICAL CANCER RESEARCH

AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription

(2011) Si Kee Tan et al.   EMBO JOURNAL

Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer

(2011) Wilbert Zwart et al.   EMBO JOURNAL

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

(2011) Biswajyoti Sahu et al.   EMBO JOURNAL

CBP Mediates NF- B-Dependent Histone Acetylation and Estrogen Receptor Recruitment to an Estrogen Response Element in the BIRC3 Promoter

(2011) M. Pradhan et al.   MOLECULAR AND CELLULAR BIOLOGY

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

(2011) Dong Wang et al.   NATURE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

PBX1 Genomic Pioneer Function Drives ERα Signaling Underlying Progression in Breast Cancer

(2011) Luca Magnani et al.   PLoS Genetics

PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer

(2010) Marleen Kok et al.   BREAST CANCER RESEARCH AND TREATMENT

Growth factor stimulation induces a distinct ER  cistrome underlying breast cancer endocrine resistance

(2010) M. Lupien et al.   GENES & DEVELOPMENT

Proinflammatory Cytokines Enhance Estrogen-dependent Expression of the Multidrug Transporter GeneABCG2through Estrogen Receptor and NFκB Cooperativity at Adjacent Response Elements

(2010) Madhumita Pradhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer

(2010) Todd W. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-Wide Analysis of Estrogen Receptor   DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation

(2010) J. D. Stender et al.   MOLECULAR AND CELLULAR BIOLOGY

FOXA1 is a key determinant of estrogen receptor function and endocrine response

(2010) Antoni Hurtado et al.   NATURE GENETICS

Androgen Receptor Inhibits Estrogen Receptor-  Activity and Is Prognostic in Breast Cancer

(2009) A. A. Peters et al.   CANCER RESEARCH

mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation

(2009) Rachel L. Yamnik et al.   FEBS LETTERS

An oestrogen-receptor-α-bound human chromatin interactome

(2009) Melissa J. Fullwood et al.   NATURE

Glucocorticoids Antagonize Estrogens by Glucocorticoid Receptor-Mediated Activation of Estrogen Sulfotransferase

(2008) H. Gong et al.   CANCER RESEARCH

Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy Resistance

(2008) Grazia Arpino et al.   ENDOCRINE REVIEWS

Synergistic Up-Regulation of Prostaglandin E Synthase Expression in Breast Cancer Cells by 17β-Estradiol and Proinflammatory Cytokines

(2008) Jonna Frasor et al.   ENDOCRINOLOGY

AKT Alters Genome-Wide Estrogen Receptor   Binding and Impacts Estrogen Signaling in Breast Cancer

(2008) P. Bhat-Nakshatri et al.   MOLECULAR AND CELLULAR BIOLOGY

Minireview: The Intersection of Steroid Receptors with Molecular Chaperones: Observations and Questions

(2008) David F. Smith et al.   MOLECULAR ENDOCRINOLOGY