Article
Acoustics
Maryam Zolghadrnasab, Amir Mousavi, Abbas Farmany, Ayyoob Arpanaei
Summary: This study synthesized PEI-coated MSNs for efficient delivery of GUS-encoding plasmid DNA into tobacco cells using ultrasound treatment. It was found that high levels of sonoporation may affect cell viability adversely. Optimal conditions for ultrasonic treatment were determined as 8 minutes at 160, 320, and 640 W, showing the potential for an economical and straightforward approach for gene transfer in plant cells.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Amelia Ultimo, Mar Orzaez, Maria J. Santos-Martinez, Ramon Martinez-Manez, Maria D. Marcos, Felix Sancenon, Eduardo Ruiz-Hernandez
Summary: The abnormal expression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium (RPE) is the main cause of subretinal neovascularisation in wet age-related macular degeneration (AMD). Encapsulating anti-VEGF drugs in large pore mesoporous silica nanoparticles (LP-MSNs) provides a potential solution for the issues in current AMD treatment, by improving drug penetration, retention time, and sustained release. In this study, an innovative LP-MSN-based nanosystem, functionalized with polyethylenimine (PEI) chains, is developed for topical administration of anti-VEGF siRNA molecules to RPE cells, demonstrating successful VEGF silencing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Minja Mladenovic, Ibrahim Morgan, Nebojsa Ilic, Mohamad Saoud, Marija V. Pergal, Goran N. Kaluderovic, Nikola Z. Knezevic
Summary: Ruthenium complexes with potent cytotoxic activity are being studied for cancer treatment, with a focus on constructing drug delivery systems using mesoporous silica nanoparticles functionalized with pH-responsive ligands to enhance the release of Ru(II) complexes in tumor acidic environments. In vitro evaluations on metastatic melanoma cells demonstrate the promising pH-responsive delivery of metallotherapeutics and targeted treatment of cancer using these designed MSN nanocarriers.
Article
Spectroscopy
Haohao Wang, Ruihong Lv, Shanshan Gao, Yuan Wang, Ning Hao, Yingli An, Yichen Li, Yongsheng Ji, Mingzhuo Cao
Summary: The interaction between functionalized degradable dendritic mesoporous silica nanoparticles (DDMSNs) and bovine serum albumin (BSA) was studied using multi-spectroscopy techniques. The results showed that the surface modification of nanoparticles had a significant impact on their physicochemical properties and biological effects. The binding modes and driving forces between nanoparticles and BSA were found to be diverse due to different surface modifications on DDMSNs, DDMSNs-NH2, and DDMSNs-NH2-HA.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Pharmacology & Pharmacy
Tais C. Ribeiro, Rafael M. Sabio, Gabriela C. Carvalho, Bruno Fonseca-Santos, Marlus Chorilli
Summary: Neurodegenerative diseases are a public health problem causing cognitive and behavioral impairments. Current drugs can only control symptoms but cannot prevent neural loss. Nanotechnology-based drug delivery systems have been developed to optimize treatment, especially for Alzheimer's and Parkinson diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Agricultural Engineering
Umme Marium Ahmad, Na Ji, Hanyang Li, Qiong Wu, Chunfeng Song, Qingling Liu, Degang Ma, Xuebin Lu
Summary: Lignin, as a potential alternative agro-chemical, can be transformed into agricultural products in various ways, making research and development on its recovery and reuse crucial. Continued innovation and collaboration are key to addressing this issue.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Multidisciplinary Sciences
Josephine Oluwagbemisola Tella, Joseph Adeyemi Adekoya, Kolawole Oluseyi Ajanaku
Summary: Conventional drug delivery systems face challenges in treating tuberculosis due to lengthy and costly treatment regimens, patient non-compliance, and drug resistance. However, novel drug delivery carrier systems like mesoporous silica nanoparticles show promise in addressing these challenges with their biocompatibility and unique physico-chemical properties.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shivalika Sharma, Kamendra P. Sharma
Summary: Soft materials made of polyethyleneimine (PEI), which combine low pH-stimulated higher-order assemblies (fibers and sheets) with light responsiveness, have been demonstrated. Interactions driven by excitation wavelength light enable the formation of bead-necklace-like structures in fibers or volume collapse of sheets. This work can have significant implications for gene transfection or encapsulation using PEI-based complexes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Agriculture, Multidisciplinary
Jing Hu, Peiting Du, Ruoyi Xu, Weijun Deng
Summary: This study fabricated supersmall dendritic mesoporous silica nanospheres (DMSNs) with tunable diameters, serving as nanocarriers for antioxidants and flavoring oils to generate stable emulsions. Gas chromatography-mass spectrometry-olfactometry (GC-MS-O) analysis demonstrated that DMSNs have outstanding protective functionalities for the encapsulated flavoring oil. The research indicates that DMSNs are an ideal platform for stable Pickering emulsions for aromatic compounds, offering a new approach for delivering flavor and sensitive bioactives with excellent stability in various applications such as food, medicine, and cosmetics.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yongbing Xu, Chunli Xu, Qiliang Huang, Lidong Cao, Feifei Teng, Pengyue Zhao, Minghong Jia
Summary: This study investigates the size effect of mesoporous silica nanoparticles on the loading, release, and delivery behavior of the pesticide pyraoxystrobin in cucumber plants. The research found that the particle size influenced the loading content and cellular uptake efficiency, with smaller nanoparticles being easier for plants to absorb and transport. Compared to free pyraoxystrobin, the nanoparticle carriers increased the upward transportation rate in plants by 3.5 times. These findings provide valuable insights for designing pesticide delivery systems using mesoporous silica nanoparticles.
APPLIED SCIENCES-BASEL
(2021)
Article
Nanoscience & Nanotechnology
Guofeng Su, Ximing Zhong, Songfa Qiu, Jiajin Fan, Hongjun Zhou, Xinhua Zhou
Summary: A novel antibacterial nanocomposite system was developed using mesoporous silica as an effective nanocarrier, demonstrating remarkable antibacterial performance due to the synergistic effect among nano zinc oxides, silver nanoparticles, and polydopamine. The presence of mesoporous silica effectively prevented the formation of large-size silver nanoparticles and facilitated their dispersion. The synergistic effect among nano zinc oxides, silver nanoparticles, and polydopamine resulted in significant antibacterial performance even at low concentrations.
Article
Pharmacology & Pharmacy
Yongsheng Ji, Shuhui Song, Xinyi Li, Ruihong Lv, Le Wu, Haohao Wang, Mingzhuo Cao
Summary: An innovative magnetic drug delivery system with a yolk-shell structure and targeting function was developed in this study, showing excellent biocompatibility and pharmaceutical effects through sustained release and enhanced cellular uptake.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Crystallography
Melissa Venedicto, Jake Carrier, Ha Na, Chen-Yu Chang, Daniela R. Radu, Cheng-Yu Lai
Summary: Mesoporous silica nanoparticles (MSNs) are utilized as carriers in drug and gene delivery research for biomedical applications due to their high surface area, consistent particle size, and minimal toxicity. By incorporating disulfide (SS) bonds into the walls of MSNs, a dual pathway for drug release is provided. Various characterization methods are employed to study the effect of embedding disulfide bonds into MSNs. The study demonstrates that MSN-SS is a promising nanocarrier for controlled-release drug delivery with efficient pH-responsive drug release behavior.
Article
Biochemistry & Molecular Biology
Min-Hsuan Tsou, Zhi-Yuan Wu, Guan-wei Chen, Cheng-Chang Lee, Zui-Harng Lee, Wei Ting Yuan, Showe-Mei Lin, Hsiu-Mei Lin
Summary: Combination therapy of chemotherapy and photodynamic therapy can improve cancer treatment. In this study, nanoparticles capable of phototherapeutic effects were synthesized, and the combination therapy demonstrated superior anticancer efficacy compared to PDT or chemotherapy alone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Joana Galhano, Goncalo A. Marcelo, Maria Paula Duarte, Elisabete Oliveira
Summary: Dual loading of drugs on mesoporous silica nanoparticles can increase the efficacy against resistant bacteria, especially in cancer patients who are highly susceptible to bacterial infections.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Lulu Wan, Gan Ye, Yuying Chang, Zhaohan Yang, Guangming Shi, Qiuli Zhang, Jin Wang
Summary: This study developed an efficient approach to upgrade the oxidative desulfurization (ODS) performance of Zr-MOFs with proton stimulation. Experimental results showed that the introduction of protons can significantly improve the ODS efficiency. This work provides a facile and efficient strategy for enhancing the ODS performance of pristine MOFs.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Qiqi Lu, Xiu-Zhi Wei, Qi Zhang, Xinghua Zhang, Lungang Chen, Jianguo Liu, Yubao Chen, Longlong Ma
Summary: The application of Pd-M bimetallic clusters in the selective hydrogenation reaction was investigated, and the Pd0.6Ni@S-1 catalyst was found to exhibit high selectivity in the conversion of phenylacetylene to styrene. The confinement effect of zeolite inhibited over-hydrogenation and improved the stability of the catalysts. Furthermore, the solvent properties also influenced the product distribution.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Review
Chemistry, Applied
Bo Li, Lumin Hong, Changdi Jing, Xianyang Yue, Huabo Huang, Qianqian Jiang, Jianguo Tang
Summary: MOF materials with adjustable pore structure and polymetallic sites have been explored as electrocatalysts for OER. Bimetallic materials show higher electrocatalytic activity than monometallic materials, while carbon-coated and doped MOF catalysts exhibit stable and good OER activity. The synergistic interaction between polymetallic active sites effectively improves the intrinsic activity of MOF on OER.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Shichun Gu, Ruyi Wang, Junxiong Zhang, Hairong Dong, Liping Deng, Xue Wang, Yapeng He
Summary: In this study, monodispersed hollow mesoporous organosilica nanospheres with controlled core cavity and mesoporous shell were successfully synthesized. These hollow nanospheres showed a high adsorption capacity for Pb2+ in water solution and exhibited acceptable recycling and stability.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Lucie Havelkova, Bogdana Bashta, Michaela Vankova, Jiri Zednik, Jiri Brus, Jan Svoboda, Alice Vagenknechtova, Jan Sedlacek
Summary: An atom-economic one-step chain-growth coordination homopolymerization providing high yields of functionalized hyper-cross-linked polyacetylenes with a permanent micro/mesoporous texture and a BET area of up to 1062 m2/g is reported. The homopolymerization is highly compatible with the heteroatom groups of the monomers and allows the preparation of well-defined porous networks with a wide spectrum of univalent groups.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Shirui Pang, Yuxin Liu, Zhe Zhang, Yuxin Li, Chunguang Li, Zhan Shi, Shouhua Feng
Summary: This study focuses on using a functional separator to suppress the shuttle effect of soluble lithium polysulfides in Li-S batteries. It is found that the functionalized sulfonic acid group not only accelerates the conduction of lithium ions, but also repels polysulfide anions through electrostatic interactions. The performance of the batteries is significantly improved with the use of this functionalized separator.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Pingping Li, Lei Han, Donghun Kim, Kemal Celebi
Summary: This study presents a fast synthetic strategy for the preparation of high-quality platelike MFI crystals using a thin-wall tubular reactor. The strategy is efficient, time-saving, and can be optimized, making it applicable to the preparation and optimization of other important materials.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Haitao Yin, Wei Wang, Yuxin Li, Hu Wen, Shuang Chen, Nanzhe Jiang
Summary: This study presents a template-free and solid-state-like crystallisation method for the synthesis of ZSM-5 zeolite, which can be scaled-up in production. Mechanical mixing of starting material components improves the dispersion of materials, leading to ZSM-5 zeolite with high crystallinity and size uniformity.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Congli Li, Jiang Wang, Zhenfei Wang, Jinxiang Dong, Qi Shi
Summary: This study investigates the evolution and autoreduction behavior of Cu species in CuCl/NaY adsorbent during vacuum thermal activation. It is found that Cu species migrate from supercages to the nearby plane of the six-membered ring connecting the supercage and sod cage during vacuum activation. At 150 degrees C, vacuum autoreduction occurs, resulting in the formation of Cu+Cl- species. The results provide reference for the preparation of pi-complex adsorbents.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Irena Khatrin, Iman Abdullah, Alan J. Mccue, Yuni K. Krisnandi
Summary: Hierarchical porous system with two types of mesopores provides a solution to the diffusion limitation in conventional zeolites. Cobalt oxide impregnated hierarchical ZSM-5 zeolite samples with intra- and inter-crystalline mesopores were synthesized using two different strategies. The physicochemical properties of the modified catalysts were analyzed, revealing distinct features given by the two mesoporous configurations. Catalytic activity analysis showed that Co-oxide/ZSM-5 with inter-crystalline mesopores exhibited higher activity in methane partial oxidation reaction compared to Co-oxide/ZSM-5 with intra-crystalline mesopores.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Nataliia Reinders, Martin Durovic, Pavla Honcova, Zaneta Dohnalova, Jana Luxova, Stanislav Slang, Jhonatan Rodriguez-Pereira, Petra S. Sulcova
Summary: This study presents a new method for preparing a microporous Ni2P/C catalyst with high catalytic activity. The redox reaction and carbon matrix formation during high-temperature treatment contribute to the stability and activity of the catalyst. Experimental and analytical results suggest that the microporous structure of the composite plays a crucial role in its catalytic performance. These findings are important for practical applications of efficient hydrogen production by water electrolysis.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Ana Raquel Bertao, Viktoriya Ivasiv, Cristina Almeida-Aguiar, Patricia R. Correia, Antonio M. Fonseca, Manuel Banobre-Lopez, Fatima Baltazar, Isabel C. Neves
Summary: This study developed a zeolite-based delivery system (ZDS) using silver and 5-Fluorouracil as antimicrobial and antineoplastic agents. The ZDS was characterized and its antimicrobial properties were investigated, showing better antibacterial effectiveness for the ZDS containing both silver and 5-FU.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Naonobu Katada, Nobuki Ozawa, Etsushi Tsuji, Keigo Kanehara, Akiho Otsuka, Taiga Sakamoto, Kirari Umezawa, Hitoshi Matsubara, Satoshi Suganuma, Momoji Kubo
Summary: First principles calculations were used to investigate the pathway for methylation of benzene with methane catalyzed by MFI type zeolite-supported Co species. The strong adsorption of benzene on Co is found to lower the activation energy for methane dissociation and promote the formation of toluene precursor. The activation energy of methane dissociation is also affected by the Al-Al distance.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Yuan Liu, An T. Ta, Kyoung Chul Park, Shenyang Hu, Natalia B. Shustova, Simon R. Phillpot
Summary: We use density functional theory to investigate the interactions of cerium, americium, and curium cations with crown ethers. Our results demonstrate that crown ethers can capture cerium, americium, and curium ions, and modifying the crown ether structure by substituting nitrogen atoms for oxygen atoms significantly increases their binding energies with radionuclides.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Zhengwu Peng, Shixing Wang, Yihui Wu, Xiang Liu, Hongliang Liu, Dekun Zhang, Likang Fu
Summary: An efficient adsorbent for recovery of germanium was prepared and characterized in this study. The adsorption behavior of Ge(IV) on the adsorbent was analyzed, and the results showed that it follows pseudo-secondary kinetic model and Langmuir isotherm model. The adsorbent exhibited good anionic anti-interference ability and can still maintain high adsorption efficiency after repeated adsorption.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)