Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish

Hypomyelinating leukodystrophies - a molecular insight into the white matter pathology

(2016) A. Charzewska et al.   CLINICAL GENETICS

σ1 receptor ligands control a switch between passive and active threat responses

(2016) Andrew J Rennekamp et al.   Nature Chemical Biology

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

(2016) Giancarlo Bruni et al.   Nature Chemical Biology

Adeno Associated Virus 9–Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice

(2016) Hideyuki Iwayama et al.   THYROID

Triiodothyroacetic Acid Treatment in MCT8 Deficiency: A Word of Nuance

(2016) W. Edward Visser et al.   THYROID

The Thyroid Hormone Analog DITPA Ameliorates Metabolic Parameters of Male Mice With Mct8 Deficiency

(2015) Alfonso Massimiliano Ferrara et al.   ENDOCRINOLOGY

Reduced synaptic density and deficient locomotor response in neuronal activity-regulated pentraxin 2a mutant zebrafish

(2015) Idan Elbaz et al.   FASEB JOURNAL

Insights into mechanisms of central nervous system myelination using zebrafish

(2015) Tim Czopka   GLIA

Hypothalamic leptin-neurotensin-hypocretin neuronal networks in zebrafish

(2015) Talia Levitas-Djerbi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a

(2015) Laura Yelin-Bekerman et al.   eLife

Placenta Passage of the Thyroid Hormone Analog DITPA to Male Wild-Type and Mct8-Deficient Mice

(2014) Alfonso Massimiliano Ferrara et al.   ENDOCRINOLOGY

Myelination Delay and Allan-Herndon-Dudley Syndrome Caused by a Novel Mutation in the SLC16A2 Gene

(2014) Roberta La Piana et al.   JOURNAL OF CHILD NEUROLOGY

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

(2014) Steffen Mayerl et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vitro and Mouse Studies Supporting Therapeutic Utility of Triiodothyroacetic Acid in MCT8 Deficiency

(2014) Simone Kersseboom et al.   MOLECULAR ENDOCRINOLOGY

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation

(2014) Naoki Tsuji et al.   PLoS One

Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation

(2014) David Zada et al.   PLoS Genetics

Expression Pattern of Thyroid Hormone Transporters in the Postnatal Mouse Brain

(2014) Julia Müller et al.   Frontiers in Endocrinology

Real-Time Visualization of Neuronal Activity during Perception

(2013) Akira Muto et al.   CURRENT BIOLOGY

Changes in Thyroid Status During Perinatal Development of MCT8-Deficient Male Mice

(2013) Alfonso Massimiliano Ferrara et al.   ENDOCRINOLOGY

Mct8-Deficient Mice Have Increased Energy Expenditure and Reduced Fat Mass That Is Abrogated by Normalization of Serum T3Levels

(2013) Caterina Di Cosmo et al.   ENDOCRINOLOGY

Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish

(2013) Angeleen Fleming et al.   PLoS One

Increased Oxidative Metabolism and Neurotransmitter Cycling in the Brain of Mice Lacking the Thyroid Hormone Transporter Slc16a2 (Mct8)

(2013) Tiago B. Rodrigues et al.   PLoS One

Imaging zebrafish neural circuitry from whole brain to synapse

(2013) Louis C. Leung et al.   Frontiers in Neural Circuits

Impact of Oatp1c1 Deficiency on Thyroid Hormone Metabolism and Action in the Mouse Brain

(2012) Steffen Mayerl et al.   ENDOCRINOLOGY

Thyroid hormone transporters and deiodinases in the developing human hypothalamus

(2012) Edith C H Friesema et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Zebrafish as a Model for Monocarboxyl Transporter 8-Deficiency

(2012) Gad David Vatine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Finding the Way into the Brain without MCT8

(2012) W. Edward Visser et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Diiodothyropropionic Acid (DITPA) in the Treatment of MCT8 Deficiency

(2012) Charles F. Verge et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic Ablation of Hypocretin Neurons Alters Behavioral State Transitions in Zebrafish

(2012) I. Elbaz et al.   JOURNAL OF NEUROSCIENCE

Schwann cell myelination requires Dynein function

(2012) Melissa M Langworthy et al.   Neural Development

Prolonged myelination in human neocortical evolution

(2012) D. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Functional Characterization of Zebrafish Solute Carrier Slc16a2 (Mct8) as a Thyroid Hormone Membrane Transporter

(2011) Francisco J. Arjona et al.   ENDOCRINOLOGY

Quantitative Membrane Protein Expression at the Blood–Brain Barrier of Adult and Younger Cynomolgus Monkeys

(2011) Katsuaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Let there be light: zebrafish neurobiology and the optogenetic revolution

(2011) Claire Wyart et al.   REVIEWS IN THE NEUROSCIENCES

Temporal dynamics of myelination in the zebrafish spinal cord

(2010) Clare E. Buckley et al.   GLIA

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects

(2010) Clare E. Buckley et al.   NEUROPHARMACOLOGY

Visualization of myelination in GFP-transgenic zebrafish

(2009) Seung-Hyun Jung et al.   DEVELOPMENTAL DYNAMICS

White matter abnormalities and dystonic motor disorder associated with mutations in the SLC16A2 gene

(2009) ARTEMIS D GIKA et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

A Thyroid Hormone Analog with Reduced Dependence on the Monocarboxylate Transporter 8 for Tissue Transport

(2009) Caterina Di Cosmo et al.   ENDOCRINOLOGY

Importance of Monocarboxylate Transporter 8 for the Blood-Brain Barrier-Dependent Availability of 3,5,3′-Triiodo-l-Thyronine

(2009) Ainhoa Ceballos et al.   ENDOCRINOLOGY

Chemical genetic screening in the zebrafish embryo

(2009) Charles K Kaufman et al.   Nature Protocols

Escape Behavior Elicited by Single, Channelrhodopsin-2-Evoked Spikes in Zebrafish Somatosensory Neurons

(2008) Adam D. Douglass et al.   CURRENT BIOLOGY

Genes involved in leukodystrophies: A glance at glial functions

(2008) Odile Boespflug-Tanguy et al.   Current Neurology and Neuroscience Reports

Zebrafish myelination: a transparent model for remyelination?

(2008) C. E. Buckley et al.   Disease Models & Mechanisms

Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier

(2008) Lori M. Roberts et al.   ENDOCRINOLOGY

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

(2008) L.-A. Harsan et al.   JOURNAL OF NEUROSCIENCE

Functional and developmental analysis of the blood–brain barrier in zebrafish

(2007) Jae-Yeon Jeong et al.   BRAIN RESEARCH BULLETIN