Article
Parasitology
Nana-Kwadwo Biritwum, Dziedzom K. de Souza, Odame Asiedu, Benjamin Marfo, Uche Veronica Amazigo, John Owusu Gyapong
Summary: The control of onchocerciasis in Ghana has been successful, with a significant decrease in infection prevalence and microfilaria load. However, there are still communities with microfilaria prevalence above 1%. Guidance and financial support are needed to ensure the elimination goal is met as the focus shifts from control to elimination.
PARASITES & VECTORS
(2021)
Article
Political Science
Line Rennwald, Jonas Pontusson
Summary: This article discusses the impact of occupation, education, and income on individuals' perception of political representation. The study reveals a distinct hierarchy based on occupation and education, with routine workers and skilled production workers feeling less represented compared to upper middle-class professionals. The research also shows that class gaps were already significant in the mid-1970s and continued to increase over the following decades. Surprisingly, perceived political influence among unionized workers has sharply declined since the 1970s.
WEST EUROPEAN POLITICS
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Ivy Chen
Summary: Recent research shows that the emotional dimensions of historic places change over time and influence visitors' experiences. This is also true for public tourist destinations, where these dimensions affect interpretive strategies and historical narratives. This essay focuses on the Castillo de San Marcos in Saint Augustine, Florida, exploring how the National Park Service (NPS) presents complex histories, how the site can go beyond Native American existence or disappearance to present narratives of survival and resistance, and how tourism sites can confront settler colonialism by centering new voices.
TOURISM GEOGRAPHIES
(2023)
Article
Public, Environmental & Occupational Health
Edvard H. Sagelv, Ulf Ekelund, Laila A. Hopstock, Nils Abel Aars, Marius Steiro Fimland, Bjarne Koster Jacobsen, Ola Lovsletten, Tom Wilsgaard, Bente Morseth
Summary: This study found no prospective association between changes in occupational physical activity and subsequent BMI changes, and did not support the hypothesis that declines in occupational physical activity contributed to population BMI gains over the past decades. Public health initiatives aimed at weight gain prevention may need to focus on aspects other than occupational physical activity.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Andreia Ribeiro, Margarida Marques, Magda S. Roberto, Ana Raposo
Summary: Two years after Portugal won the UEFA European Championship, researchers found that people's memories of this event can be categorized into flashbulb memories and event memories, which are determined by different factors. Event memories can predict flashbulb memories and enhance memory for the reception context. The findings suggest a close interaction between these two types of memories.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Social
Joshua Uyheng, Gilana Kim T. Roxas, Martina Magpusao Herras
Summary: Across various nascent democracies, historical memories of past conflicts are often challenged, and sociogenesis concept helps to understand how contested memories are symbolically mediated in different spaces. Textbooks and social media present different representations of the Marcos dictatorship in the Philippines, with textbooks using balanced reporting strategies and social media leaning towards insurgent nostalgia.
ASIAN JOURNAL OF SOCIAL PSYCHOLOGY
(2021)
Article
Clinical Neurology
Chloe W. Eng, Elizabeth R. Mayeda, Paola Gilsanz, Rachel A. Whitmer, Anthony S. Kim, M. Maria Glymour
Summary: The study found that decreases in stroke incidence rates may be associated with smaller memory decrements immediately after stroke onset. Additionally, reductions in stroke incidence and improvements in stroke care may also reduce the population burden of dementia. Further investigations into whether temporal trends are attributable to improvements in stroke care are necessary.
Article
Business
Andrea Tunarosa
Summary: Understanding the construction of market categories requires consideration of their specific location. Existing research tends to view location as the mere background against which market actors shape the meaning of a category. Through an inductive study of the US specialty coffee category spanning over four decades, this study proposes a grounded model of category construction through dynamic emplacement. This model recognizes the ongoing efforts of actors to ground category meanings in specific places and the role of places in enhancing the credibility of the category. It shifts the research focus from socio-cognitive explanations to the material experiences and transformations of categories.
STRATEGIC ORGANIZATION
(2023)
Article
Microbiology
Jing Li, Mengnan Hong, Baiyu Qi
Summary: The application of T. delbrueckii in ice wine fermentation can increase aroma complexity and enhance the characteristic taste and aroma of ice wine.
FRONTIERS IN MICROBIOLOGY
(2022)
Biographical-Item
Optics
Natan T. Shaked, YongKeun Park, Stephen A. Boppart, Adam Wax, Peter T. C. So
Summary: Gabriel Popescu will be remembered as a creative leader in biophotonics, making pioneering contributions to quantitative phase imaging and spectroscopy. He was also known as an engaging collaborator and a dear friend.
Article
Psychology, Experimental
Jasmine Raw, Alice Rorke, Judi Ellis, Kou Murayama, Michiko Sakaki
Summary: Compared to nonemotional events, emotional public events are usually remembered more accurately, vividly, and with more confidence. This study specifically examined the memory of individuals regarding the United Kingdom's 2016 Referendum on its European Union membership, and found that positive and negative public events are remembered differently.
Article
Endocrinology & Metabolism
Edvard H. Sagelv, Ulf Ekelund, Laila A. Hopstock, Marius Steiro Fimland, Ola Lovsletten, Tom Wilsgaard, Bente Morseth
Summary: The study found no association between leisure time physical activity changes and subsequent BMI changes, whereas BMI change predicted subsequent physical activity change. These findings suggest that BMI change predicts subsequent physical activity change at the population level and not vice versa.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Biotechnology & Applied Microbiology
Ke Tang, Yulu Sun, Xiaoqian Zhang, Jiming Li, Yan Xu
Summary: This study investigated the aroma composition and sensory attributes of Vidal icewine fermented with four different yeast strains. Results showed that icewine fermented by the R2 yeast strain had higher levels of honey and nut aroma attributes compared to others. Partial least squares discriminant analysis identified 40 compounds responsible for the differences in aroma characteristics among the icewines fermented by the four yeasts.
FERMENTATION-BASEL
(2021)
Article
Environmental Sciences
Pedro Henrique Bof, Guilherme Fernandes Marques, Amaury Tilmant, Ana Paula Dalcin, Marcelo Olivares
Summary: Energy generation, food production, and water availability have a strong interdependency and correlation, bringing challenges that require a deeper understanding to support decision-making. Results suggest that under uncertainty, an economically compensated water reallocation strategy should be considered to address the competitive uses of water resources.
Biographical-Item
Optics
Yasuo Koide
Summary: Isamu Akasaki, the 2014 Nobel laureate, passed away at the age of 92 in April. He was well-known for his invention of efficient blue light-emitting diodes and research into new semiconductor materials.
Article
Multidisciplinary Sciences
A. Roichman, S. Elhanati, M. A. Aon, I Abramovich, A. Di Francesco, Y. Shahar, M. Y. Avivi, M. Shurgi, A. Rubinstein, Y. Wiesner, A. Shuchami, Z. Petrover, I Lebenthal-Loinger, O. Yaron, A. Lyashkov, C. Ubaida-Mohien, Y. Kanfi, B. Lerrer, P. J. Fernandez-Marcos, M. Serrano, E. Gottlieb, R. de Cabo, H. Y. Cohen
Summary: The study demonstrates that overexpression of SIRT6 extends lifespan in mice and optimizes energy homeostasis in old age, delaying frailty and preserving healthy aging. Aged SIRT6-transgenic mice maintain hepatic glucose output and glucose homeostasis through improved utilization of two major gluconeogenic precursors, lactate, and glycerol.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Raquel Luna-Yolba, Justine Marmoiton, Veronique Gigo, Xavier Marechal, Emeline Boet, Ambrine Sahal, Nathalie Alet, Ifat Abramovich, Eyal Gottlieb, Virgile Visentin, Michael R. Paillasse, Jean-Emmanuel Sarry
Summary: This study confirms the increase in oxidative phosphorylation upon cytarabine resistance in AML cells and identifies a new role of ETCI in the regulation of immune checkpoints PD-L1 and CD39 in both murine and human leukemic cells. The novel selective ETC I inhibitor EVT-701 reduces OxPHOS metabolism and CD39/PD-L1 expression in cytarabine-resistant leukemic cells, potentially improving the anti-tumor immune response in AML.
Review
Endocrinology & Metabolism
Manuel Grima-Reyes, Adriana Martinez-Turtos, Ifat Abramovich, Eyal Gottlieb, Johanna Chiche, Jean-Ehrland Ricci
Summary: This article highlights the importance and methods of studying tumor metabolism using in vivo isotope tracing. Research findings suggest that metabolic dependencies in cancers are influenced by tissue environment, cancer lineage, and genetic events, providing crucial clues for identifying key alterations contributing to cancer onset and progression.
MOLECULAR METABOLISM
(2021)
Article
Oncology
Maty Tzukerman, Yeela Shamai, Ifat Abramovich, Eyal Gottlieb, Sara Selig, Karl Skorecki
Summary: The APOL1 gene risk variants are associated with increased risk of kidney disease and renal cell carcinoma in individuals of African ancestry. Using gene editing technology, researchers have demonstrated that APOL1 risk variants have significant effects on the proliferation, mitochondrial morphology, cell metabolism, and tumorigenic potential of renal cell carcinoma cells. These findings highlight the significant role of APOL1 in the pathogenesis of renal cell carcinoma and provide motivations for further studies.
Article
Biochemistry & Molecular Biology
Dmitry Miskevich, Anastasia Chaban, Maria Dronina, Ifat Abramovich, Eyal Gottlieb, Imad Shams
Summary: The study compared glucose metabolism in primary Spalax and rat skin cells under normoxic and hypoxic conditions, finding that Spalax cells utilize glucose for pentose phosphate pathway maintenance and production of glutathione and UDP-GlcNAc, with an upregulation of lactate dehydrogenase to maintain NAD(+) pool. Mitochondrial homeostasis in Spalax cells under both normoxia and hypoxia is characterized by massive cataplerotic flux along alpha KG & RARR;Glu & RARR;Pro & RARR;hydroxyproline (HPro) axis.
Editorial Material
Cell Biology
Ross Cagan, Kevan Shokat
DISEASE MODELS & MECHANISMS
(2022)
Article
Biochemistry & Molecular Biology
A. Saragovi, T. Zilberman, G. Yasur, K. Turjeman, I. Abramovich, M. Kuchersky, E. Gottlieb, Y. Barenholz, M. Berger
Summary: This study examines the increase of water mass in T cells during cell growth. It finds that T-cell growth is characterized by two phases of water increase and that T cells switch from metabolizing water to rapidly taking up water from the extracellular medium before cell division.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Oren Rom, Yuhao Liu, Alexandra C. Finney, Alia Ghrayeb, Ying Zhao, Yousef Shukha, Lu Wang, Krishani K. Rajanayake, Sandeep Das, Nabil A. Rashdan, Natan Weissman, Luisa Delgadillo, Bo Wen, Minerva T. Garcia-Barrio, Michael Aviram, Christopher G. Kevil, Arif Yurdagul, Christopher B. Pattillo, Jifeng Zhang, Duxin Sun, Tony Hayek, Eyal Gottlieb, Inbal Mor, Y. Eugene Chen
Summary: This study found that lower levels of glycine in the blood are associated with cardiovascular disease, particularly atherosclerosis. They also discovered a glycine-based compound called DT109 that has potential for treating atherosclerosis.
Article
Biochemistry & Molecular Biology
Lubna Willi, Ifat Abramovich, Jonatan Fernandez-Garcia, Bella Agranovich, Margarita Shulman, Helena Milman, Polina Baskin, Binyamin Eisen, Daniel E. Michele, Michael Arad, Ofer Binah, Eyal Gottlieb
Summary: This study found that cardiomyocytes from DMD patients exhibit bioenergetic and metabolic impairments, along with rhythm disturbances corresponding to the patient's phenotype, providing novel targets for alleviating cardiomyopathy in DMD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Avigail Rein, Ifat Geron, Eitan Kugler, Hila Fishman, Eyal Gottlieb, Ifat Abramovich, Amir Giladi, Ido Amit, Roger Mulet-Lazaro, Ruud Delwel, Stefan Groeschel, Smadar Levin-Zaidman, Nili Dezorella, Vered Holdengreber, Tata Nageswara Rao, Joanne Yacobovich, Orna Steinberg-Shemer, Qiu-Hua Huang, Yun Tan, Sai-Juan Chen, Shai Izraeli, Yehudit Birger
Summary: Mono-allelic germline disruptions of the GATA2 transcription factor can lead to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This study shows the role of GATA2 mutations in the development of AML and identifies mitochondrial abnormalities as a potential therapeutic target for preventing leukemic transformation.
Article
Cell Biology
Majdoleen Ahmad, Ifat Abramovich, Bella Agranovich, Alina Nemirovski, Eyal Gottlieb, Liad Hinden, Joseph Tam
Summary: Tubulopathy is crucial in the pathophysiology of diabetic kidney disease (DKD), particularly the role of GLUT2 in promoting glucose reabsorption and glucotoxicity, as well as regulating SGLT2 expression in kidney proximal tubule cells (KPTCs). Reduction/deletion of KPTC-GLUT2 has shown promising results in ameliorating DKD, making it a potential therapeutic target. However, the molecular mechanisms underlying the deleterious effects of GLUT2 in KPTCs remain unclear.
Article
Dermatology
Steven D. Rhodes, Frank McCormick, Ross L. Cagan, Annette Bakker, Verena Staedtke, Ina Ly, Matthew R. Steensma, Sang Y. Lee, Carlos G. Romo, Jaishri O. Blakeley, Kavita Y. Sarin
Summary: Cutaneous neurofibromas (cNFs) are the most common tumors in neurofibromatosis type 1 patients, and there is a lack of effective interventions for their treatment. To develop new therapies, it is essential to understand the biology of cNFs, including the role of RAS signaling and downstream pathways. This review provides an overview of the current knowledge on RAS signaling in cNF pathogenesis and therapeutic development.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Verena Staedtke, Piotr Topilko, Lu Q. Le, Kevin Grimes, David A. Largaespada, Ross L. Cagan, Matthew R. Steensma, Anat Stemmer-Rachamimov, Jaishri O. Blakeley, Steven D. Rhodes, Ina Ly, Carlos G. Romo, Sang Y. Lee, Eduard Serra
Summary: Neurofibromatosis type 1 (NF1) is caused by a nonfunctional NF1 tumor suppressor gene, resulting in the development of cutaneous neurofibromas (cNFs). Incomplete understanding of cNF pathophysiology and limitations in experimental modeling have hindered the development of cNF treatment. Recent advances in preclinical in vitro and in vivo modeling provide unprecedented opportunities for therapeutic discovery and improving our understanding of cNF biology.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Genetics & Heredity
Alexander Teague, Maria M. Quintero, Fateme Karimi Dermani, Ross M. Cagan, Erdem Bangi
Summary: Understanding the genetic complexity and underlying mechanisms of human disease is crucial. Researchers have developed a technique in Drosophila that allows simultaneous and controlled manipulation of multiple genes from a single transgenic construct. This method is particularly useful for modeling complex diseases and studying biological processes that involve multiple gene interactions.
Article
Endocrinology & Metabolism
Samantha J. Linder, Tiziano Bernasocchi, Barbara Martinez-Pastor, Kelly D. Sullivan, Matthew D. Galbraith, Caroline A. Lewis, Christina M. Ferrer, Ruben Boon, Giorgia G. Silveira, Hyo Min Cho, Charles Vidoudez, Stuti Shroff, Joao P. Oliveira-Costa, Kenneth N. Ross, Rami Massri, Yusuke Matoba, Eugene Kim, Bo R. Rueda, Shannon L. Stott, Eyal Gottlieb, Joaquin M. Espinosa, Raul Mostoslavsky
Summary: This study reveals an adaptive pathway in cancer cells that allows them to survive under glutamine starvation by downregulating proline biosynthesis and promoting de novo glutamine synthesis. This pathway highlights a previously unrecognized metabolic plasticity of cancer cells and suggests a potential target for developing metabolism-driven anticancer therapies.
