Review
Immunology
Thais Teixeira Oliveira, Leonam Gomes Coutinho, Laysa Ohana Alves de Oliveira, Ana Rafaela de Souza Timoteo, Guilherme Cavalcanti Farias, Lucymara Fassarella Agnez-Lima
Summary: APE1 is a multifunctional enzyme that is essential for maintaining cellular homeostasis and regulating immune response. It plays important roles in cell signaling, senescence, and inflammatory pathways, and is involved in the pathogenesis of various diseases, including cancer and neurological disorders. APE1 inhibitors have potential therapeutic uses, particularly in infectious and immune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lauren Sahakian, Ainsley M. Robinson, Linda Sahakian, Rhian Stavely, Mark R. Kelley, Kulmira Nurgali
Summary: Inflammatory bowel disease (IBD) is a chronic relapsing inflammation of the gastrointestinal tract. The prevalence of IBD is increasing worldwide, calling for the development of new treatments. APE1/Ref-1 has been identified as a potential target for IBD therapy due to its role in regulating crucial pathways in inflammatory diseases. This review discusses the current status of IBD treatments, the role of APE1/Ref-1 in intestinal inflammation, and the potential of small molecule inhibitors to modulate inflammation and oxidative stress in IBD.
Article
Biochemistry & Molecular Biology
Eun-Ok Lee, Hee-Kyoung Joo, Yu-Ran Lee, Sungmin Kim, Kwon-Ho Lee, Sang-Do Lee, Byeong-Hwa Jeon
Summary: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is involved in DNA repair and redox regulation. It inhibits adipocyte differentiation by regulating adipogenic transcription factors, suggesting it as a potential therapeutic target for regulating adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anna Maria Grimaldi, Cristina Lapucci, Marco Salvatore, Mariarosaria Incoronato, Maurizio Ferrari
Summary: This systematic review analyzes the effectiveness of urine miRNAs as diagnostic markers for bladder cancer. Although there were high-quality studies, the results were quite heterogeneous and no consistent miRNA signature was found.
Review
Immunology
Wujun Chen, Shuai Wang, Dongming Xing
Summary: APE1/Ref-1 and ABCA1 play crucial roles in the progression of atherosclerosis, with APE1/Ref-1 suppressing athero-sclerosis via multiple mechanisms and ABCA1 promoting cholesterol efflux and anti-inflammatory responses. Both proteins could be potential therapeutic targets for atherosclerosis treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Medicine, General & Internal
Ryan Tsz-Hei Tse, Hongda Zhao, Christine Yim-Ping Wong, Carol Ka-Lo Cheng, Angel Wing-Yan Kong, Qiang Peng, Peter Ka-Fung Chiu, Chi-Fai Ng, Jeremy Yuen-Chun Teoh
Summary: Urinary cell-free DNA (ucfDNA) is a promising tool for bladder cancer detection and molecular classification, as it can differentiate bladder cancer patients from healthy controls based on its molecular features and identify unique genetic features of bladder cancer. Additionally, ucfDNA exhibits significant differences in non-muscle-invasive and muscle-invasive bladder cancers, showing its potential for future applications in the field.
Article
Biochemistry & Molecular Biology
Sunga Choi, Yu-Ran Lee, Ki-Mo Kim, Euna Choi, Byeong-Hwa Jeon
Summary: The regulation of inflammatory signaling in the tumor microenvironment using adenoviral-mediated PPTLS-APE1/Ref-1 can inhibit the activity of inflammatory immune cells and cancer cells, providing a potential therapeutic strategy for treating triple-negative breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Krzysztof Ossolinski, Tomasz Ruman, Valerie Copie, Brian P. Tripet, Artur Kolodziej, Aneta Plaza-Altamer, Anna Ossolinska, Tadeusz Ossolinski, Anna Nieczaj, Joanna Niziol
Summary: This study investigated polar metabolite profiles in urine samples from BC patients and normal controls using NMR and LDI-MS and identified potential markers for bladder cancer. The metabolites were able to distinguish urine samples from BC and NCs individuals, and correlate with tumor stages and grades. The findings suggest that these metabolite markers may be useful for non-invasive detection and monitoring of bladder cancer.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Oncology
Zhenghong Liu, Li Sun, Bin Zheng, Heng Wang, Xiaowen Qin, Pu Zhang, Qijun Wo, Haichang Li, Yixuan Mou, Dahong Zhang, Shuai Wang
Summary: This study found that abnormal overexpression of ATAD3A in bladder cancer tissues is associated with pathological features and prognosis of patients. ATAD3A overexpression is correlated with patient age, tumor characteristics, and stage. High expression of ATAD3A indicates reduced survival rate in bladder cancer patients.
Article
Immunology
Fei Li, Henghui Zhang, Yu Wang, Zhihao Yao, Kunfeng Xie, Qixin Mo, Qin Fan, Lina Hou, Fan Deng, Wanlong Tan
Summary: Fibroblast growth factor binding protein 1 (FGFBP1) is upregulated in failures of BCG therapy and is associated with poor prognosis and immune escape in bladder cancer patients. There is a positive correlation between FGFBP1 and PD-L1 expression, making it a potential biomarker for accurately predicting BCG response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Engineering, Environmental
Xu Hong, Gengfu Wang, Xingcun Liu, Ming Wu, Xindong Zhang, Xiaohui Hua, Pengpeng Jiang, Sheng Wang, Song Tang, Xiaoming Shi, Yichao Huang, Tong Shen
Summary: This study found a higher level of bisphenol A (BPA) in the urine of colorectal cancer (CRC) patients compared to controls, and a positive correlation between BPA and CRC biomarkers. Lipidomic screening revealed significant perturbation in the glycerophospholipid metabolism pathway, which contributed to the association between BPA exposure and CRC. These findings contribute to a better understanding of the etiology of CRC induced by environmental stressors.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Lei Jiang, Zhongqiang Zuo, Jie Lin, Chuanfeng Yang
Summary: Our study revealed that OTX1 is highly expressed in bladder cancer cells and tissues, and is significantly associated with poor prognosis. Silencing OTX1 reduced cell viability, growth and motility, while overexpression of OTX1 had opposite effects. The co-expressed genes of OTX1 were enriched in cell cycle-related pathways, indicating a potential role of OTX1 in bladder cancer progression.
Article
Multidisciplinary Sciences
T. Kloskowski, K. Szeliski, K. Krzeszowiak, Z. Fekner, L. Kazimierski, A. Jundzill, T. Drewa, M. Pokrywczynska
Summary: The study found that Mumio exhibited significant cytotoxicity to urinary bladder cancer cells, while having minimal impact on normal cells. Mumio works by inhibiting the cell cycle of cancer cells and inducing apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-Ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Summary: Inhibiting Ref-1 redox signaling alters cancer cell metabolism by causing TCA cycle dysfunction and reduces pancreatic tumor growth in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seon-Ah Jin, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: Deletion of CRIF1 in endothelial cells leads to impaired cardiac function, likely due to mitochondrial dysfunction, oxidative stress, inflammation, and decreased expression of SIRT1. The SIRT1 inducer SRT1720 improves cardiac dysfunction by activating endothelial nitric oxide synthase, reducing oxidative stress, and inhibiting inflammation.
Article
Medicine, General & Internal
In Seol Yoo, Yu-Ran Lee, Seong Wook Kang, Jinhyun Kim, Hee-Kyoung Joo, Su-Jin Yoo, Chan Keol Park, Ha-Reum Lee, Ji Ah Park, Byeong-Hwa Jeon
Summary: The study demonstrates that the levels of APE1/Ref-1 are significantly elevated in the serum and synovial fluid of rheumatoid arthritis patients, and are positively correlated with disease activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Byeong Hwa Jeon
Article
Biochemistry & Molecular Biology
Yu-Ran Lee, Eun Young Bae, Hong Ryang Kil, Byeong-Hwa Jeon, Geena Kim
Summary: This study investigated the association between APE1/Ref-1 and Kawasaki disease (KD). The results showed that APE1/Ref-1 levels were significantly higher in KD patients, especially in refractory KD. APE1/Ref-1 could be a beneficial biomarker for the diagnosis and prognosis of KD.
Article
Biochemistry & Molecular Biology
Su-jeong Choi, Harsha Nagar, Jun Wan Lee, Seonhee Kim, Ikjun Lee, Shuyu Piao, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: This study found that IDH2 deficiency induced increased expression of SDC2 in endothelial cells, with MMP7 and TGF-beta signaling playing regulatory roles. UTI could reverse the increase in SDC2, MMP7, and TGF-beta signaling caused by IDH2 deficiency.
Article
Biochemistry & Molecular Biology
Sunga Choi, Yu-Ran Lee, Ki-Mo Kim, Euna Choi, Byeong-Hwa Jeon
Summary: The regulation of inflammatory signaling in the tumor microenvironment using adenoviral-mediated PPTLS-APE1/Ref-1 can inhibit the activity of inflammatory immune cells and cancer cells, providing a potential therapeutic strategy for treating triple-negative breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sungmin Kim, Yu-Ran Lee, Eun-Ok Lee, Hao Jin, Yeon-Hee Choi, Hee-Kyoung Joo, Byeong-Hwa Jeon
Summary: This study found that dietary capsanthin has anti-inflammatory and anti-vascular inflammation effects on atherosclerotic mice, reducing plaque formation and inflammatory marker levels.
Article
Biochemistry & Molecular Biology
Eun-Ok Lee, Hee-Kyoung Joo, Yu-Ran Lee, Sungmin Kim, Kwon-Ho Lee, Sang-Do Lee, Byeong-Hwa Jeon
Summary: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is involved in DNA repair and redox regulation. It inhibits adipocyte differentiation by regulating adipogenic transcription factors, suggesting it as a potential therapeutic target for regulating adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seonhee Kim, Hyewon Park, Harsha Nagar, Su-Jeong Choi, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong-Hwa Jeon, Dong Woon Kim, Youngduk Seo, Cuk-Seong Kim
Summary: This study investigates the role of CRIF1 deficiency in modulating mitochondrial oxidative phosphorylation (OXPHOS) system dysfunction and its antitumor effects in MCF-7 breast cancer cells. CRIF1 silencing decreases the assembly of mitochondrial OXPHOS complexes, leading to mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels. Inhibition of CRIF1 suppresses cell proliferation and inhibits cell migration in MCF-7 cells, and intratumoral injection of CRIF1 siRNA nanoparticles inhibits tumor growth in MCF-7 xenograft mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Minsoo Kim, Giang-Huong Vu, Byeong-Hwa Jeon, Cuk-Seong Kim
Summary: Endothelial senescence impairs vascular function and is a major factor in age-related vasculature diseases. IDH2 is involved in the production of alpha-ketoglutarate and preservation of mitochondrial function. However, the mechanism and regulation of IDH2 in endothelial senescence have not been fully understood.
Article
Urology & Nephrology
Jong Mok Park, Sung-Jong Eun, Yong Gil Na
Summary: In this paper, an optimal ureter stone detection model utilizing multiple artificial intelligence technologies is proposed. The model merges an artificial intelligence model and an image processing model, resulting in a multimethod approach for urinary tract stone detection. The results show that the proposed method achieves high accuracy in detecting urinary tract stones, confirming its potential in supporting actual surgery.
INTERNATIONAL NEUROUROLOGY JOURNAL
(2023)
Article
Medicine, General & Internal
Yumin Jo, Yeojung Kim, Eunhye Park, Yuran Lee, Jiyeon Kim, Minwoong Kang, Jaesung Lim, Insang Song, Chaeseong Lim, Byeonghwa Jeon
Summary: The study found that the plasma APE1/Ref-1 level of patients undergoing cancer surgery increases and is related to the degree of lymph node invasion, but is not affected by the choice of different anesthetics.
MEDICINA-LITHUANIA
(2021)
Article
Nutrition & Dietetics
Ki Mo Kim, Joo Young Lee, Byeong Hwa Jeon, Khong Trong Quan, MinKyun Na, Kung-Woo Nam, Sungwook Chae
Summary: The study showed that dietary intake of Curcuma zedoaria extract reduced atherosclerosis in mice, along with decreasing serum triglyceride and high-density lipoprotein levels, and reducing inflammatory molecule expression.
NUTRITION RESEARCH AND PRACTICE
(2021)
Review
Urology & Nephrology
Su Jin Kim, Jayoung Kim, Yong Gil Na, Khae Hawn Kim
Summary: Underactive bladder and impaired bladder compliance are irreversible problems associated with bladder fibrosis. Remodeling of the extracellular matrix is considered as an important mechanism in bladder fibrosis. However, various risk factors and conditions contribute to the functional impairment of the bladder due to fibrosis, and there is limited knowledge in the field of neurourology. Further studies are necessary to elucidate the underlying mechanism of bladder fibrosis and to identify effective treatment.
INTERNATIONAL NEUROUROLOGY JOURNAL
(2021)