Journal
DISEASE MARKERS
Volume 2016, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2016/9510756
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Funding
- Consejo Nacional de Ciencia y Tecnologia, Mexico [FOSISS-2009-114484]
- National Institutes of Health R01 Grant [AI91526]
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In order to determine if the expression of the activation marker CD38 can correlate with HIV disease progression independently of cycling, we performed a cluster-based multivariate correlation analysis of total circulating CD4(+) T cell counts and viral loads with frequencies of CD38 and Ki67 expression on CD4(+) lymphocytes from patients with untreated HIV infection, stratified in maturation subpopulations, and subpopulation subsets defined by the expression of CXCR5, CXCR3, and CCR4. The frequencies of the activated phenotypes %CD38(+) Ki67(-) and % CD38(+) Ki67(+) of the CXCR5(-) CXCR3(-) CCR4(+) (pre-Th2) central memory (T-CM) cell subset clustered together, comprising a significant negative correlate of total circulating CD4(+) T cell counts and a positive correlate of viral load in multivariate analysis. Frequency of cycling-uncoupled CD38 expression in pre-Th2 TCM cells was a negative correlate of total circulating CD4(+) T cell counts in univariate analysis, which was not the case of their % CD38(+) Ki67(+). CXCR5(+) CXCR3(-) CCR4(-) T-CM cells were underrepresented in patients, and their absolute counts correlated negatively with their % CD38(+) Ki67(-) but not with their % CD38(+) Ki67(+). Our results may imply that CD38 expression either reflects or participates in pathogenic mechanisms of HIV disease independently of cell cycling.
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