A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections

Chloroquine and hydroxychloroquine as available weapons to fight COVID-19

(2020) Philippe Colson et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

(2020) Jianjun Gao et al.   BioScience Trends

Zinc Iodide in combination with Dimethyl Sulfoxide for treatment of SARS-CoV-2 and other viral infections

(2020) Ba X. Hoang et al.   MEDICAL HYPOTHESES

Antibacterial activity of hinokitiol against both antibiotic‐resistant and ‐susceptible pathogenic bacteria predominant in the oral cavity and upper airways

(2019) Hisanori Domon et al.   MICROBIOLOGY AND IMMUNOLOGY

The Role of Zinc in Antiviral Immunity

(2019) Scott A Read et al.   Advances in Nutrition

Zinc: A Potential Antiviral Against Hepatitis E Virus Infection?

(2018) Nidhi Kaushik et al.   DNA AND CELL BIOLOGY

Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

(2015) J Ye et al.   EYE

Current understanding of ZIP and ZnT zinc transporters in human health and diseases

(2014) Taiho Kambe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hinokitiol induces autophagy in murine breast and colorectal cancer cells

(2014) Wei-Kuang Wang et al.   ENVIRONMENTAL TOXICOLOGY

Hinokitiol Induces DNA Damage and Autophagy followed by Cell Cycle Arrest and Senescence in Gefitinib-Resistant Lung Adenocarcinoma Cells

(2014) Lan-Hui Li et al.   PLoS One

Chloroquine Is a Zinc Ionophore

(2014) Jing Xue et al.   PLoS One

Zinc ionophores pyrithione inhibits herpes simplex virus replication through interfering with proteasome function and NF-κB activation

(2013) Min Qiu et al.   ANTIVIRAL RESEARCH

In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines

(2013) Yin-Hua Shih et al.   MICROBIOLOGICAL RESEARCH

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Zinc lozenges as cure for the common cold – A review and hypothesis

(2009) George A. Eby   MEDICAL HYPOTHESES

Clioquinol targets zinc to lysosomes in human cancer cells

(2008) Haijun Yu et al.   BIOCHEMICAL JOURNAL

Role of Zn2+ Ions in Host-Virus Interactions

(2008) M. Lazarczyk et al.   JOURNAL OF VIROLOGY

Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections

(2008) B. M. Krenn et al.   JOURNAL OF VIROLOGY

Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

(2008) Se Byeon et al.   PLANTA MEDICA