4.6 Article

Fabrication of polyhydroxy butyric acid-Gelatin blended nanofibrous matrix integrated with silver sulfadiazine as an alternate wound dressing for treating burns

Journal

MATERIALS LETTERS
Volume 282, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.matlet.2020.128541

Keywords

Biomaterials; Biomimetic; Polymeric composites; Nanocomposites; Porous materials; Electron microscopy

Funding

  1. ICMR, New Delhi, India [5/7/1133/2014-RCH]

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The electrospinning of PHB-Gelatin nanofibrous matrix loaded with SSD serves as a stable carrier to prevent infection at burn wound site, reducing dressing frequency and promoting wound healing.
The design of an alternate wound dressing material is necessary to overcome difficulties such as less contact time formulations, more extended hospitalization, and prevent secondary infection. Herein, we report the electrospinning of Polyhydroxy butyric acid (PHB) -Gelatin (70:30) nanofibrous matrix loaded with Silver sulfadiazine (SSD) (0.2% w/v) to act as a carrier to prevent infection at second degree burn wound site. The nanofibrous matrix proves to facilitate good stability against exudates absorption and oxygen permeability. The controlled delivery of the SSD tends to reduce the dressing frequency. The biocompatibility and cell adhesion were assessed with NIH 3T3 fibroblast. The in vivo burn wounds supported enhanced re-epithelialization and MMP-9 production exhibited with fast healing of wound from day 18. Thus, the nanofibrous scaffold serves as an alternate wound dressing material in treating burns by reducing dressing frequency and lessening the adverse effects of antibiotics by its limited usage. (C) 2020 Elsevier B.V. All rights reserved.

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