Article
Biochemistry & Molecular Biology
J. L. Pichardo-Molina, P. E. Cardoso-Avila, R. J. Patakfalvi, L. Aparicio-Ixta, F. Pedro-Garcia, H. J. Ojeda-Galvan, L. L. Flores-Villavicencio, J. C. Villagomez-Castro
Summary: We synthesized fluorescent carbon nanoparticles (FC-NPs) with a size of 5.5 nm using a novel one-pot direct synthesis method. These FC-NPs could be produced at room temperature without calcination, minimizing waste and reducing synthesis and purification time. The FC-NPs exhibited strong fluorescence with emission peaks at around 450 nm and 555 nm, making them suitable for various applications including cell biomarkers in human, plant cell lines, and microbial cultures.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Ting Wang, Kondo-Francois Aguey-Zinsou
Summary: Borohydride nanoparticles were synthesized successfully using a modified ternary anti-precipitation method. The addition of a co-solvent and the carbon chain length of the stabilising surfactant play crucial roles in controlling particle size. This method offers an effective and simple way to prepare nanosized borohydride particles for hydrogen storage, while reducing the contamination of hydrogen release caused by stabilising surfactants.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Review
Medicine, Research & Experimental
Qingsong Ye, Deyuan Zheng, Kaiyuan Chen, Jinhui Wu
Summary: Ischemia or hypoxia can cause pathological changes in tissue metabolism and function, leading to various diseases. Timely and effective blood resuscitation or improvement of hypoxia is crucial for disease treatment. However, the development of stable, non-toxic, and immunologically inert oxygen carriers is necessary due to limitations such as blood shortages and the risk of infections. Hemoglobin and perfluorocarbon-based oxygen carriers have been widely studied, and this paper reviews their development and applications as blood substitutes or oxygen carriers in hypoxic diseases. The design of oxygen carriers, their characteristics, and future research prospects are also discussed to provide a reference for further studies.
MOLECULAR PHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Peng Yin, Ming-Xi Chen, Ming Zuo, Le-Le Zhang, Hai-Wei Liang
Summary: Atomically ordered intermetallic compounds (IMCs) have been synthesized with average particle sizes of < 4 nm by a general synthesis strategy based on the strong chemical interaction between metal and sulfur. These Rh-based IMC catalysts showed enhanced catalytic performance for nitroarene hydrogenation, highlighting the advantages of atomically order structure of IMCs for the chemoselective molecular recognition of nitro groups through geometric and electronic effects.
ACS MATERIALS LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Peng Yin, Ming-Xi Chen, Ming Zuo, Le-Le Zhang, Hai-Wei Liang
Summary: Atomically ordered intermetallic compounds (IMCs) have unique electronic and geometric features that have sparked continuous research interest in catalysis. A general synthesis strategy has been developed to prepare a family of 10 different Rh-based IMCs with average particle sizes of <4 nm, which show enhanced catalytic performance for nitroarene hydrogenation. The atomically ordered structure of IMCs demonstrates advantages in chemoselective molecular recognition of nitro groups through geometric and electronic effects.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Negar Hassani Besheli, Martijn Martens, Elena Macias-Sanchez, Jos Olijve, Fang Yang, Nico Sommerdijk, Sander C. G. Leeuwenburgh
Summary: Through time-resolved analysis and visualization, we elucidated the formation mechanism of gelatin nanoparticles (GNPs), with the ability to precisely control their physicochemical and biofunctional properties by manipulating gelatin molecular weight and type of desolvating agent.
Review
Chemistry, Multidisciplinary
Pai Liu, Tianyue Yang, Yaning Li, Jun Guo, Shulan Li, Hongli Chen, Yi Liu
Summary: Sonodynamic therapy (SDT) is a novel therapeutic method with deep penetration, good cell membrane permeability, and the ability to be exposed to light. However, the hypoxic tumor microenvironment and poor targeting of sonosensitizers limit the treatment efficiency of SDT. Therefore, constructing sonosensitizer-based nanoplatforms is crucial for achieving a more comprehensive therapeutic effect.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Pharmacology & Pharmacy
Lei Kuang, Yu Zhu, Yue Wu, Kunlun Tian, Xiaoyong Peng, Mingying Xue, Xinming Xiang, Billy Lau, Fei Chuen Tzang, Liangming Liu, Tao Li
Summary: YQ23 showed better outcomes compared to LR in hypotensive resuscitation by reducing blood loss and fluid demand, stabilizing hemodynamics, increasing oxygen delivery, reducing organ injury, extending survival time without significant side effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Pharmacology & Pharmacy
Pavel Khramtsov, Tatyana Kalashnikova, Maria Bochkova, Maria Kropaneva, Valeria Timganova, Svetlana Zamorina, Mikhail Rayev
Summary: The desolvation technique is commonly used for preparing protein nanoparticles. Different analytical methods are compared in this study to determine the concentration and effects of cross-linking on protein nanoparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Chris E. Cooper, Matthew Bird, XiaoBo Sheng, Ji-Won Choi, Gary G. A. Silkstone, Michelle Simons, Natalie Syrett, Riccardo Piano, Luca Ronda, Stefano Bettati, Gianluca Paredi, Andrea Mozzarelli, Brandon J. Reeder
Summary: In order to increase stability and prolong vascular retention of a Hemoglobin Based Oxygen Carrier, using a mono-sulfone-PEG instead of maleimide-PEG may be more appropriate. Mono-sulfone-PEG shows higher efficiency and stability in PEGylation of hemoglobin, making it a potential option for pharmaceuticals intended for longer vascular retention.
FRONTIERS IN CHEMISTRY
(2021)
Article
Physiology
Jie Zhang, Yue Wu, Xiao-Yong Peng, Qing-Hui Li, Xin-Ming Xiang, Yu Zhu, Qing-Guang Yan, Billy Lau, Feichuen Tzang, Liang-Ming Liu, Tao Li
Summary: YQ23 effectively alleviates acute altitude hypoxia injury of AMS by improving general behavior and vital signs, enhancing blood oxygen saturation, and mitigating cardiac ischemia and vital organ injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lijie Gao, Meng Wang, Shuyu Li, Kui Chen, Lina Zhou, Xin Li, Na Wang, Xin Huang, Hongxun Hao, Ting Wang
Summary: This study investigates the phase transition and nucleation process of different polymorphs of DM5AIP using fluorescence changes. The results show that DM5AIP molecules prefer H-aggregates as the concentration increases in acetonitrile. The evaporation crystallization process of DM5AIP is successfully monitored in real time, and the aggregation evolution is studied using FTIR spectroscopy and NMR spectrometry.
Article
Materials Science, Biomaterials
Qi Wang, Jin Gong, Qingqing Bai, Yuling Qin, Xiaobo Zhou, Mingmin Wu, Haiwei Ji, Li Wu
Summary: Hemoglobin-functionalized HKUST-1 shows excellent oxygen loading capacity and good chemical durability, making it a promising artificial blood substitute with sustained electrochemical responses towards H2O2 and O-2.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Genetics & Heredity
Weronika Kruczkowska, Mateusz Kciuk, Zbigniew Pasieka, Karol Klosinski, Elzbieta Pluciennik, Jacob Elmer, Klaudia Waszczykowska, Damian Kolat, Zaneta Kaluzinska-Kolat
Summary: The diminishing supply and increasing costs of donated blood have led to the development of novel HBOCs as RBC substitutes. Ecs, giant metalloproteins found in invertebrates, show promise as they possess efficient oxygen transport, anti-inflammatory properties, and can be further modified to enhance their effectiveness. This literature review focuses on the structure, properties, and application of Ecs, highlighting their advantages over other HBOCs. The development of stabilization and purification methods for erythrocruorin could greatly improve access to artificial blood resources.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Surgery
Megan O'Connor, Rachana Patil, Jiangzhou Yu, Richard Hickey, Kavitha Premanand, Andre Kajdacsy-Balla, Enrico Benedetti, Amelia Bartholomew
PHOTOMEDICINE AND LASER SURGERY
(2016)
Article
Biotechnology & Applied Microbiology
Ivan S. Pires, Donald A. Belcher, Richard Hickey, Colbert Miller, Abraham K. Badu-Tawiah, Jin Hyen Baek, Paul W. Buehler, Andre F. Palmer
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Materials Science, Biomaterials
Chintan Savla, Carlos Munoz, Richard Hickey, Maria Belicak, Christopher Gilbert, Pedro Cabrales, Andre F. Palmer
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Multidisciplinary Sciences
Jingjing Zhang, Luong T H Nguyen, Richard Hickey, Nicole Walters, Xinyu Wang, Kwang Joo Kwak, L. James Lee, Andre F. Palmer, Eduardo Reategui
Summary: The iSUF method provides a rapid and efficient way to purify and enrich EVs, with the ability to remove contaminating proteins and isolate tumor-specific EVs. EVs processed by iSUF from clinical samples show significantly higher expression levels of tumor biomarkers.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Mitchell R. H. Weigand, Jenifer Gomez-Pastora, James Kim, Matthew T. Kurek, Richard J. Hickey, David C. Irwin, Paul W. Buehler, Maciej Zborowski, Andre F. Palmer, Jeffrey J. Chalmers
Summary: A new enzymatic deoxygenation method using EC-Oxyrase (R) is described, which produces pure deoxyHb with little to no side reactions. The method allows for easy re-oxygenation and has similar paramagnetic mobility to existing methods. Hemoglobin from healthy RBCs treated with EC-Oxyrase (R) shows unchanged function, confirming the efficacy of this enzymatic approach.
Article
Multidisciplinary Sciences
Xiangming Gu, Richard Hickey, Antara Rath, Andre F. Palmer
Summary: The goal of this study was to develop a novel manufacturing strategy for large-scale production of metHb. Small-scale screening experiments were conducted to determine the optimal molar ratio of Hb to oxidizing agents. The synthesized metHb showed stability and potential as a non-O-2 carrying control material.
Article
Nanoscience & Nanotechnology
Emily M. McDonel, Richard Hickey, Andre F. Palmer
ACS APPLIED NANO MATERIALS
(2020)
Proceedings Paper
Biophysics
Nicholas Marjanovic, Kevin Kerr, Ricardo Aranda, Richard Hickey, Hananeh Esmailbeigi
2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2017)
Meeting Abstract
Surgery
R. Patil, K. Premanand, L. Halliday, E. Szilagyi, M. Willman, J. Yu, R. Hickey, D. Berman, A. Antony, F. Pan, X. Wang, K. McHenry, D. Salomon, N. Kenyon, A. Bartholomew
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
